TB-Profiler result

Run: ERR190340
Summary

Run ID: ERR190340

Sample name:

Date: 2024-10-04T12:40:38.667162

Number of reads: 780693

Percentage reads mapped: 99.41

Median coverage: 17.0

Strain: lineage3.1;lineage4.9.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.6
lineage4.9.1 Euro-American (H37Rv-like) None 0.24
lineage4 Euro-American None 0.42
lineage4.9 Euro-American (H37Rv-like) None 0.42
lineage3.1 East-African-Indian RD750 0.73
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.66 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8978 c.1677C>T synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 0.68 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.62 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 0.71 ethionamide Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 0.52 rifampicin Not assoc w R
rpoB 762434 c.2628T>G synonymous_variant 0.59 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 0.65 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.44 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.63 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
tsnR 1854300 p.Leu232Pro missense_variant 0.54 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.74 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.59 pyrazinamide Not assoc w R
PPE35 2170461 p.Gly51Glu missense_variant 0.71 pyrazinamide Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 0.77 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.54 pyrazinamide
pncA 2289448 c.-207G>A upstream_gene_variant 0.42 pyrazinamide
Rv2477c 2782498 c.1545C>T synonymous_variant 0.59 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 0.56 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.29 rifampicin Not assoc w R
bedaquiline Uncertain significance
panD 4044872 c.-591C>T upstream_gene_variant 0.58 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.59 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240172 p.Val104Met missense_variant 0.71 ethambutol Not assoc w R
embC 4241562 p.Arg567His missense_variant 0.65 ethambutol Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 0.64 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.67 ethambutol Not assoc w R
embA 4243323 p.Val31Ile missense_variant 0.5 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338846 c.-325T>G upstream_gene_variant 0.59 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.75 streptomycin Not assoc w R