TB-Profiler result

Run: ERR2510427
Summary

Run ID: ERR2510427

Sample name:

Date: 31-03-2023 18:44:12

Number of reads: 822600

Percentage reads mapped: 99.76

Strain: lineage4.9

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7570 p.Ala90Val missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289081 p.Pro54Leu missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6204 p.Ser322Asn missense_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576400 c.1053C>T synonymous_variant 1.0
rpoB 760609 p.Leu268Arg missense_variant 0.1
rpoB 760999 p.Met398Thr missense_variant 0.13
rpoB 761461 p.Arg552Leu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1833575 p.Ala12Thr missense_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154694 p.Val473Asp missense_variant 0.1
PPE35 2169013 p.Val534Leu missense_variant 0.29
PPE35 2169067 p.Ala516Thr missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3087367 p.Ala183Val missense_variant 1.0
rpoA 3877536 c.972C>T synonymous_variant 1.0
aftB 4267964 c.873T>A synonymous_variant 0.15
ubiA 4269124 p.Ala237Val missense_variant 1.0
whiB6 4338307 p.Ala72Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0