TB-Profiler result

Run: ERR2510482
Summary

Run ID: ERR2510482

Sample name:

Date: 31-03-2023 18:46:06

Number of reads: 811362

Percentage reads mapped: 99.67

Strain: lineage4.9

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289081 p.Pro54Leu missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576400 c.1053C>T synonymous_variant 1.0
rpoB 759982 p.Ile59Asn missense_variant 0.1
rpoB 761461 p.Arg552Leu missense_variant 0.97
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169091 p.Val508Leu missense_variant 0.18
PPE35 2169483 p.Ala377Val missense_variant 0.11
PPE35 2170048 p.Leu189Val missense_variant 0.61
PPE35 2170053 p.Thr187Ser missense_variant 0.56
Rv1979c 2222278 p.Gly296Glu missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2987001 p.Val55Ile missense_variant 0.12
Rv2752c 3064708 p.Arg495Gln missense_variant 0.1
Rv2752c 3064876 p.Ser439Phe missense_variant 1.0
ald 3087367 p.Ala183Val missense_variant 1.0
Rv3083 3448961 c.462delC frameshift_variant 0.18
rpoA 3877536 c.972C>T synonymous_variant 1.0
embA 4244549 c.1317C>T synonymous_variant 0.17
embB 4246548 p.Pro12Gln missense_variant 0.12
embB 4246555 c.42G>C synonymous_variant 0.14
embB 4246556 p.Ala15Pro missense_variant 0.13
ubiA 4269124 p.Ala237Val missense_variant 1.0
whiB6 4338307 p.Ala72Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0