TB-Profiler result

Run: ERR3275190
Summary

Run ID: ERR3275190

Sample name:

Date: 2024-03-24T15:45:30.422244

Number of reads: 1646838

Percentage reads mapped: 99.56

Median coverage: 30.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.77 amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.64 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9596 c.2295G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13277 c.282T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13524 p.Gly12Ala missense_variant 1.0 isoniazid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619983 c.93G>A synonymous_variant 1.0 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734354 p.Pro34Leu missense_variant 1.0 rifampicin Not assoc w R
nusG 734753 p.Thr167Met missense_variant 1.0 rifampicin Not assoc w R
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 761558 c.1752C>A synonymous_variant 0.22 rifampicin
rpoB 761579 c.1773G>T synonymous_variant 0.21 rifampicin
rpoB 761591 c.1785C>T synonymous_variant 0.22 rifampicin
rpoB 761594 c.1788C>A synonymous_variant 0.21 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.21 rifampicin
rpoB 761642 c.1836G>C synonymous_variant 0.18 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762173 p.Glu789Asp missense_variant 0.31 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762200 c.2394C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.55 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.58 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762248 c.2442G>C synonymous_variant 0.56 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762269 c.2463G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>A synonymous_variant 0.36 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.32 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762297 p.Leu831Met missense_variant 0.23 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762905 p.Asp1033Glu missense_variant 0.31 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 762932 c.-438G>C upstream_gene_variant 0.44 rifampicin
rpoC 762938 c.-432G>T upstream_gene_variant 0.53 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.6 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.59 rifampicin
rpoB 763005 p.Cys1067Val missense_variant 0.59 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.68 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.69 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.68 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.68 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763100 c.-270G>A upstream_gene_variant 0.51 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.51 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763118 c.-252G>A upstream_gene_variant 0.49 rifampicin
rpoB 763130 p.Glu1108Asp missense_variant 0.44 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.39 rifampicin
rpoB 763145 c.3339G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.35 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763444 p.Tyr25* stop_gained 0.17 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764181 p.Asp271Gly missense_variant 1.0 rifampicin Not assoc w R
rpoC 764503 c.1134G>T synonymous_variant 0.21 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.27 rifampicin
rpoC 764545 c.1176C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.27 rifampicin
rpoC 764551 c.1182G>T synonymous_variant 0.28 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.28 rifampicin
rpoC 764562 p.Pro398Leu missense_variant 0.28 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.27 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.27 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCT frameshift_variant&synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>C synonymous_variant 0.28 rifampicin
rpoC 764912 p.Met515Val missense_variant 0.28 rifampicin
rpoC 764917 c.1548G>C synonymous_variant 0.29 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.29 rifampicin
rpoC 764926 c.1557C>T synonymous_variant 0.3 rifampicin
rpoC 764929 c.1560G>A synonymous_variant 0.3 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.29 rifampicin
rpoC 764947 c.1578G>C synonymous_variant 0.3 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764952 p.Val528Ala missense_variant 0.3 rifampicin
rpoC 764959 c.1590G>A synonymous_variant 0.36 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>A synonymous_variant 0.31 rifampicin
rpoC 764998 c.1629G>C synonymous_variant 0.32 rifampicin
rpoC 765007 c.1638T>C synonymous_variant 0.26 rifampicin
rpoC 765008 c.1639T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>C synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781410 c.-150G>C upstream_gene_variant 0.96 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81insAAGCTTG non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471929 n.84C>G non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471931 n.87_89delAGA non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471980 n.135G>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsTA non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472670 n.825_838delGGGTTTCCTTCCTTinsAGGGGACTTCCAC non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472685 n.840G>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472690 n.845C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472843 n.998_999insT non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1002delG non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472855 n.1011_1012insGT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472859 n.1014_1016delGCGinsT non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472971 n.1126G>A non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472972 n.1127T>C non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246G>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473120 n.1275C>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473132 n.1287T>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473289 n.1444_1445delTCinsCTTG non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473676 n.19G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473698 n.41G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473699 n.42A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473700 n.43G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473724 n.67T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473731 n.74T>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.11 capreomycin
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_527delCCTCinsTAA non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474186 n.529A>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629C>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474287 n.630T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474293 n.637_650delCCTCTCCGGAGGAG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474310 n.655delG non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474371 n.714C>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474378 n.721G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2101_2108delACCCGCAA non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475767 n.2110_2112delGGTinsTCACTTTGGTGGC non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475990 n.2333G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476028 n.2372_2375delAACC non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476034 n.2377_2378insACAT non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476048 n.2391G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476049 n.2392C>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476091 n.2434_2435insG non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476100 n.2443A>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476188 n.2531C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476276 n.2619C>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476523 n.2867delC non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476595 n.2938C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476602 n.2945G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833877 c.336C>A synonymous_variant 0.3 pyrazinamide
rpsA 1833884 p.Thr115Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1833894 p.Ala118Glu missense_variant 0.34 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.34 pyrazinamide
rpsA 1833914 p.Ala125Pro missense_variant 0.35 pyrazinamide
rpsA 1833919 c.378C>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1833921 p.Lys127Thr missense_variant 0.36 pyrazinamide
rpsA 1833925 c.384C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834561 c.1020C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834567 p.Asp342Glu missense_variant 0.29 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.3 pyrazinamide
rpsA 1834572 p.Ala344Val missense_variant 0.3 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834624 c.1083G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834636 c.1095C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834637 p.Asn366Asp missense_variant 0.3 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834667 c.1126_1128delGCGinsTC frameshift_variant&missense_variant 0.46 pyrazinamide Uncertain significance
rpsA 1834684 c.1143C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.56 pyrazinamide
rpsA 1834705 c.1164C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.51 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834753 c.1212T>G synonymous_variant 0.48 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.46 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.37 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834792 c.1251G>T synonymous_variant 0.24 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170769 c.-157C>T upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.97 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 0.96 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240926 p.Cys355Phe missense_variant 1.0 ethambutol Uncertain significance
embC 4242075 p.Arg738Gln missense_variant 0.97 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247566 c.1053C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 0.98 streptomycin Not assoc w R