TB-Profiler result

Run: ERR3275220
Summary

Run ID: ERR3275220

Sample name:

Date: 2024-10-03T21:56:19.231858

Number of reads: 2202423

Percentage reads mapped: 99.53

Median coverage: 42.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6280 c.1041T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8078 c.777A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9422 c.2121C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9596 c.2295G>T synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13277 c.282T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491196 c.414A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491295 c.513C>G synonymous_variant 0.14 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.14 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
ccsA 620349 c.459A>G synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.13 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 0.98 ethionamide Not assoc w R - Interim
nusG 734354 p.Pro34Leu missense_variant 1.0 rifampicin Not assoc w R
nusG 734541 c.288A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734753 p.Thr167Met missense_variant 0.88 rifampicin Not assoc w R
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760283 c.477G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.15 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.13 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.13 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.14 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.17 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.18 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.16 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.25 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.16 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.16 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.18 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.16 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.18 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.95 rifampicin Not assoc w R
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.14 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763486 c.117T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764181 p.Asp271Gly missense_variant 0.89 rifampicin Not assoc w R
rpoC 764206 c.837T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.22 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.18 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.18 rifampicin
rpoC 764714 c.1345C>T synonymous_variant 0.16 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.16 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.15 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.13 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765325 c.1956C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.14 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.15 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.15 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.16 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.15 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 800844 c.36T>C synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254749 c.-215C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.29 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.29 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.26 isoniazid
ethionamide
rpsA 1833619 c.78A>C synonymous_variant 0.14 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.13 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155641 p.Lys157Asn missense_variant 0.24 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170769 c.-157C>T upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.2 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2783077 c.966T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3066040 p.Gly51Thr missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066042 c.150T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066050 p.Leu48Met missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625797 p.Val273Met missense_variant 0.17 rifampicin Uncertain significance
bedaquiline Uncertain significance
rpoA 3878217 c.291A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878396 c.112C>T synonymous_variant 0.2 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.23 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.23 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.17 rifampicin
clpC1 4038740 c.1965G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.13 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.18 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.9 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.14 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.14 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.14 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.13 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.14 ethambutol
embC 4242075 p.Arg738Gln missense_variant 0.97 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4244454 p.Ala408Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4247500 c.987C>G synonymous_variant 0.13 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.16 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.16 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.13 ethambutol
embB 4248011 p.Ser500Ala missense_variant 0.13 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.17 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.17 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.17 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248095 c.1582_1584delCTCinsTTG synonymous_variant 0.14 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.18 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.18 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.16 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.15 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.16 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.16 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.14 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.15 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.13 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.13 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.12 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.16 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.15 ethambutol
embB 4249483 c.2970C>G synonymous_variant 0.14 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.14 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R