Run ID: ERR4799673
Sample name:
Date: 2024-04-15T01:59:43.925495
Number of reads: 4501180
Percentage reads mapped: 99.3
Median coverage: 128.0
Strain: lineage1.2.2.2
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage1.2.2 | Indo-Oceanic | RD239 | 0.98 |
| lineage1.2.2.2 | Indo-Oceanic | RD239 | 0.99 |
| lineage1 | Indo-Oceanic | RD239 | 0.99 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 5075 | c.-165C>T | upstream_gene_variant | 0.99 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5151 | c.-89C>A | upstream_gene_variant | 0.99 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrB | 6112 | p.Met291Ile | missense_variant | 0.97 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 8452 | p.Ala384Val | missense_variant | 0.97 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 0.99 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| Rv0010c | 13298 | p.Ile87Met | missense_variant | 0.99 | isoniazid | Not assoc w R |
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 0.96 | isoniazid | Not assoc w R |
| Rv0010c | 13482 | p.Ala26Val | missense_variant | 0.97 | isoniazid | Not assoc w R |
| Rv0010c | 13699 | c.-141A>G | upstream_gene_variant | 0.98 | isoniazid | Not assoc w R |
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 0.98 | ethionamide | |
| nusG | 734116 | c.-138T>C | upstream_gene_variant | 0.99 | rifampicin | Not assoc w R |
| rpoB | 759538 | c.-269G>C | upstream_gene_variant | 0.99 | rifampicin | |
| rpoB | 760735 | p.Val310Gly | missense_variant | 0.96 | rifampicin | Uncertain significance |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R |
| rpoC | 763884 | p.Ala172Val | missense_variant | 0.98 | rifampicin | Not assoc w R |
| rpoC | 763886 | c.517C>A | synonymous_variant | 0.97 | rifampicin | Not assoc w R |
| rpoC | 766073 | p.Ala902Thr | missense_variant | 0.98 | rifampicin | Uncertain significance |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rplC | 800357 | c.-452C>A | upstream_gene_variant | 0.99 | linezolid | Not assoc w R |
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| sigE | 1365153 | c.741C>A | synonymous_variant | 0.99 | pyrazinamide | |
| embR | 1417019 | p.Cys110Tyr | missense_variant | 0.96 | ethambutol | Not assoc w R |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 0.98 | ethambutol | |
| embR | 1417793 | c.-446C>T | upstream_gene_variant | 0.99 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrl | 1476669 | n.3012C>T | non_coding_transcript_exon_variant | 0.99 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| tsnR | 1853974 | c.369C>T | synonymous_variant | 0.97 | linezolid | Not assoc w R |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 0.99 | linezolid | Not assoc w R |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| bacA | 2062922 | p.Ile603Val | missense_variant | 0.97 | streptomycin | Not assoc w R |
| kanamycin | Not assoc w R | |||||
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2168742 | p.Gly624Asp | missense_variant | 0.98 | pyrazinamide | Uncertain significance |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 0.99 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223553 | c.-389C>A | upstream_gene_variant | 0.97 | clofazimine | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| kasA | 2518132 | c.18C>T | synonymous_variant | 0.98 | isoniazid | |
| ahpC | 2726051 | c.-142G>A | upstream_gene_variant | 0.98 | isoniazid | |
| ahpC | 2726427 | p.Asp79Asn | missense_variant | 0.98 | isoniazid | Uncertain significance |
| Rv2477c | 2783404 | c.639C>T | synonymous_variant | 0.97 | ethambutol | |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| pepQ | 2860150 | p.Ala90Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | ||||||
| Rv2680 | 2996254 | c.150G>A | synonymous_variant | 0.99 | capreomycin | Not assoc w R - Interim |
| Rv2752c | 3064889 | p.Lys435Glu | missense_variant | 0.98 | ethambutol | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| Rv3083 | 3448714 | p.Asp71His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3626467 | c.147G>A | synonymous_variant | 0.99 | bedaquiline | Not assoc w R - Interim |
| rifampicin | Not assoc w R | |||||
| mtrA | 3627602 | c.-253C>T | upstream_gene_variant | 0.99 | bedaquiline | Uncertain significance |
| rifampicin | Uncertain significance | |||||
| alr | 3841546 | c.-126C>A | upstream_gene_variant | 0.95 | cycloserine | |
| alr | 3841568 | c.-148G>A | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841570 | c.-151delA | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841574 | c.-154T>G | upstream_gene_variant | 0.96 | cycloserine | |
| alr | 3841578 | c.-158G>T | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841582 | c.-162A>G | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841584 | c.-164C>A | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841589 | c.-170delG | upstream_gene_variant | 0.93 | cycloserine | |
| alr | 3841612 | c.-193_-192insC | upstream_gene_variant | 0.87 | cycloserine | |
| clpC1 | 4040517 | p.Val63Ala | missense_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| glpK | 4138377 | p.Val460Ala | missense_variant | 0.96 | ethambutol | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4241042 | p.Asn394Asp | missense_variant | 0.99 | ethambutol | Not assoc w R |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4245969 | p.Pro913Ser | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247646 | p.Glu378Ala | missense_variant | 0.99 | ethambutol | Not assoc w R |
| aftB | 4268735 | c.102C>G | synonymous_variant | 0.99 | ethambutol | |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ethA | 4326439 | p.Asn345Lys | missense_variant | 0.99 | ethionamide | Uncertain significance |
| whiB6 | 4338447 | c.75C>T | synonymous_variant | 0.98 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338603 | c.-82C>T | upstream_gene_variant | 0.99 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338635 | c.-114A>C | upstream_gene_variant | 0.99 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4407873 | c.330G>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
