TB-Profiler result

Run: ERR4799980

Summary

Run ID: ERR4799980

Sample name:

Date: 01-04-2023 09:30:47

Number of reads: 2859942

Percentage reads mapped: 99.49

Strain: lineage2.2.1

Drug-resistance: XDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.95
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.95
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.95
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Gly missense_variant 0.95 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 0.97 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.96 streptomycin
rplC 801268 p.Cys154Arg missense_variant 0.93 linezolid
katG 2155168 p.Ser315Thr missense_variant 0.93 isoniazid
pncA 2288713 p.Thr177Pro missense_variant 0.96 pyrazinamide
thyX 3067961 c.-16C>T upstream_gene_variant 0.93 para-aminosalicylic_acid
embB 4247429 p.Met306Val missense_variant 0.94 ethambutol
thyA 3073347 c.-874_*332del transcript_ablation 1.0 para-aminosalicylic_acid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 0.99
ccsA 620625 p.Ile245Met missense_variant 0.93
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764840 p.Ile491Val missense_variant 0.97
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 0.93
mmpR5 779181 c.198delG frameshift_variant 0.13
mmpS5 779615 c.-710C>G upstream_gene_variant 0.98
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98
rrs 1471658 n.-188T>A upstream_gene_variant 0.15
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1833963 p.Asp141Gly missense_variant 0.2
rpsA 1834177 c.636A>C synonymous_variant 0.96
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 0.96
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086979 c.165_166dupGC frameshift_variant 0.93
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
Rv3236c 3612813 p.Thr102Ala missense_variant 0.98
embC 4241022 p.Ala387Val missense_variant 0.93
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.96
aftB 4267647 p.Asp397Gly missense_variant 0.86
ethA 4326458 p.Ile339Asn missense_variant 0.93
whiB6 4338336 c.185dupG frameshift_variant 0.96
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.98
gid 4407620 p.Tyr195His missense_variant 0.95
gid 4407927 p.Glu92Asp missense_variant 0.97