TB-Profiler result

Run: ERR4813750
Summary

Run ID: ERR4813750

Sample name:

Date: 01-04-2023 12:58:14

Number of reads: 3205812

Percentage reads mapped: 99.68

Strain: lineage4.1.2;lineage2.2.1

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.91
lineage4 Euro-American LAM;T;S;X;H None 0.07
lineage4.1 Euro-American T;X;H None 0.06
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.92
lineage4.1.2 Euro-American T;H None 0.06
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.92
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.9 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.93 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.92
mshA 575907 p.Ala187Val missense_variant 0.89
ccsA 620625 p.Ile245Met missense_variant 0.87
rpoC 763031 c.-339T>C upstream_gene_variant 0.86
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.92
mmpL5 776182 p.Asp767Asn missense_variant 0.9
mmpS5 779615 c.-710C>G upstream_gene_variant 0.85
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.86
rrs 1471647 n.-199G>A upstream_gene_variant 0.92
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.9
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.9
PPE35 2167926 p.Leu896Ser missense_variant 0.93
PPE35 2168963 c.1650A>G synonymous_variant 0.15
PPE35 2169053 c.1560T>C synonymous_variant 0.24
PPE35 2169059 c.1554G>A synonymous_variant 0.19
PPE35 2169063 p.Met517Thr missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.93
alr 3840263 c.1158C>T synonymous_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.93
aftB 4267647 p.Asp397Gly missense_variant 0.97
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.88
gid 4407927 p.Glu92Asp missense_variant 0.91