TB-Profiler result

Run: ERR4821011
Summary

Run ID: ERR4821011

Sample name:

Date: 01-04-2023 17:00:45

Number of reads: 325732

Percentage reads mapped: 67.62

Strain: lineage6

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage6 West-Africa 2 AFRI_1 RD702 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.74 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 6934 c.-368A>G upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8493 p.Leu398Phe missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491668 p.Lys296Glu missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 760855 p.Thr350Ile missense_variant 1.0
rpoB 760969 p.Ser388Leu missense_variant 1.0
rpoB 761723 p.Glu639Asp missense_variant 1.0
rpoB 762143 c.2337T>C synonymous_variant 0.2
rpoB 762149 c.2343G>C synonymous_variant 0.22
rpoB 762156 p.Val784Ile missense_variant 0.2
rpoB 762167 c.2361T>C synonymous_variant 0.2
rpoB 762177 p.Arg791Thr missense_variant 0.25
rpoB 762181 p.Asp792Ala missense_variant 0.25
rpoB 762185 c.2379G>C synonymous_variant 0.25
rpoB 762194 c.2388G>C synonymous_variant 0.25
rpoB 762218 c.2412T>C synonymous_variant 0.29
rpoB 762426 p.Ser874Pro missense_variant 0.22
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763747 c.380delA frameshift_variant 0.22
rpoC 766231 c.2862T>C synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
Rv1258c 1406685 p.Val219Ala missense_variant 1.0
embR 1416633 p.Leu239Val missense_variant 1.0
atpE 1461251 c.207G>T synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471729 n.-117T>C upstream_gene_variant 0.2
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.85
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.71
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.71
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.71
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.89
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.14
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.7
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.58
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.24
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.62
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.9
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.43
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.33
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.5
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.56
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.56
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.73
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.72
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.73
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.73
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.14
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.74
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.77
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.73
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.88
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.97
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.19
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.75
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.74
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.34
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.33
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 1.0
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.71
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.67
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.6
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.67
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.75
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.75
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.75
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 0.67
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.75
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.56
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.21
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.67
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.27
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.62
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.67
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.68
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.17
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.67
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.17
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.86
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.94
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.86
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.71
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.86
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.79
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.78
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.78
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.2
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.2
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.93
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.6
rrs 1472997 n.1152G>A non_coding_transcript_exon_variant 0.14
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.62
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 1.0
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.89
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.89
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.89
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.5
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.5
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.57
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.43
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.57
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.5
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.57
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.62
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.5
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.62
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.62
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.69
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.64
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.54
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.54
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.36
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.5
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.46
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.55
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.55
rrs 1473293 n.1449delA non_coding_transcript_exon_variant 0.67
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.67
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.67
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.57
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.75
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.75
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.75
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.75
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.75
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.75
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.5
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.67
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.67
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.33
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.33
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 1.0
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.5
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.5
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.67
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.67
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.67
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 1.0
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 1.0
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.67
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.67
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.67
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.75
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.8
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.86
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.57
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.81
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.73
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.64
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.4
fabG1 1673743 p.Glu102Lys missense_variant 0.22
inhA 1674434 p.Val78Ala missense_variant 1.0
rpsA 1834261 c.720A>G synonymous_variant 0.22
rpsA 1834294 c.753G>C synonymous_variant 0.44
rpsA 1834298 p.Gln253Glu missense_variant 0.44
rpsA 1834306 c.765T>C synonymous_variant 0.25
rpsA 1834307 p.Asp256Gln missense_variant 0.25
rpsA 1834312 c.771G>A synonymous_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168137 p.Ile826Val missense_variant 0.2
PPE35 2168452 c.2158_2160delGTC conservative_inframe_deletion 0.14
PPE35 2169461 c.1151delT frameshift_variant 0.22
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2518786 p.Glu224Asp missense_variant 0.22
folC 2747425 c.174C>T synonymous_variant 0.4
pepQ 2860570 c.-152A>G upstream_gene_variant 0.22
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
Rv3083 3449396 p.Cys298Tyr missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
Rv3236c 3612143 p.Arg325His missense_variant 1.0
Rv3236c 3612750 c.366delC frameshift_variant 0.22
alr 3841495 c.-75G>T upstream_gene_variant 0.13
panD 4044341 c.-60C>T upstream_gene_variant 0.17
panD 4044432 c.-151T>G upstream_gene_variant 1.0
embC 4241120 p.Ser420Arg missense_variant 0.5
embC 4241843 p.Leu661Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embA 4244379 p.Pro383Ser missense_variant 1.0
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269522 c.-686C>T upstream_gene_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
aftB 4269693 c.-857C>T upstream_gene_variant 1.0
ethA 4326465 p.Ile337Val missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408034 p.Glu57Lys missense_variant 1.0
gid 4408090 p.Pro38Leu missense_variant 0.22