Run ID: ERR4830826
Sample name:
Date: 20-10-2023 06:46:18
Number of reads: 2360963
Percentage reads mapped: 99.69
Strain: lineage4.8;lineage4.2.2.2
Drug-resistance: HR-TB
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | ||
Isoniazid | R | katG p.Ser315Thr (0.13) |
Ethambutol | R | embB p.Met306Ile (0.15), embB p.Gly406Asp (0.14) |
Pyrazinamide | R | pncA p.Phe58Leu (0.17) |
Streptomycin | R | gid p.Gly69Asp (0.12) |
Fluoroquinolones | ||
Moxifloxacin | ||
Ofloxacin | ||
Levofloxacin | ||
Ciprofloxacin | ||
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.2 | Euro-American | H;T;LAM | None | 0.12 |
lineage4.8 | Euro-American (mainly T) | T1;T2;T3;T5 | RD219 | 0.82 |
lineage4.2.2 | Euro-American (Ural) | T;LAM7-TUR | None | 0.13 |
lineage4.2.2.2 | Euro-American (Ural) | T;LAM7-TUR | None | 0.13 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
katG | 2155168 | p.Ser315Thr | missense_variant | 0.13 | isoniazid |
pncA | 2289068 | p.Phe58Leu | missense_variant | 0.17 | pyrazinamide |
embB | 4247431 | p.Met306Ile | missense_variant | 0.15 | ethambutol |
embB | 4247730 | p.Gly406Asp | missense_variant | 0.14 | ethambutol |
gid | 4407997 | p.Gly69Asp | missense_variant | 0.12 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 8688 | p.Ala463Ser | missense_variant | 0.18 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.13 |
mshA | 576077 | c.730C>T | synonymous_variant | 0.15 |
rpoB | 760975 | p.Met390Thr | missense_variant | 0.85 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.85 |
rrl | 1475090 | n.1433A>C | non_coding_transcript_exon_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2168149 | p.Pro822Ser | missense_variant | 0.77 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
ahpC | 2726146 | c.-47_-46insT | upstream_gene_variant | 0.23 |
thyA | 3074100 | p.Asp124Glu | missense_variant | 0.89 |
ald | 3086742 | c.-78A>C | upstream_gene_variant | 0.17 |
ald | 3086767 | c.-53A>C | upstream_gene_variant | 0.81 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 0.22 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 0.15 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
aftB | 4267715 | c.1122G>A | synonymous_variant | 0.92 |
ethA | 4327472 | c.2T>G | start_lost | 0.21 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |