TB-Profiler result

Run: ERR5087486
Summary

Run ID: ERR5087486

Sample name:

Date: 01-04-2023 22:02:50

Number of reads: 1815226

Percentage reads mapped: 95.37

Strain: La1.8.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
La1 M.bovis None None 1.0
La1.8 M.bovis None None 1.0
La1.8.1 M.bovis None None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.24 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.29 kanamycin, capreomycin, aminoglycosides, amikacin
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5752 c.513G>A synonymous_variant 1.0
gyrA 6406 c.-896C>T upstream_gene_variant 1.0
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8285 c.984C>T synonymous_variant 1.0
gyrA 8741 c.1440C>T synonymous_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9217 p.Asp639Ala missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.33
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.33
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.33
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.29
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.22
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.2
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.15
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.13
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.14
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.14
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.14
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.31
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.31
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.28
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.28
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.29
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.29
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.36
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.4
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.43
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.4
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.4
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.28
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.27
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.27
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.27
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.29
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.29
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.27
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.31
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.31
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.33
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.22
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.25
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.25
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.25
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 0.29
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.29
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.29
rrl 1474291 n.635_645delTTCCTCTCCGG non_coding_transcript_exon_variant 0.25
rrl 1474305 n.648G>T non_coding_transcript_exon_variant 0.22
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.25
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.25
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.25
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.2
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.18
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.18
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.17
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.29
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.25
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.25
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.22
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.18
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.22
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.22
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.22
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.2
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.25
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.22
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.22
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.22
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.22
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.27
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.3
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.25
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.25
rrl 1474935 n.1278A>G non_coding_transcript_exon_variant 0.22
rrl 1474938 n.1281G>A non_coding_transcript_exon_variant 0.22
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.4
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.43
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.3
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.18
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.15
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.15
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.15
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.17
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.22
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.2
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.18
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.18
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.5
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.5
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.5
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.5
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.5
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.5
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.5
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.5
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.5
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.5
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.33
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.43
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.33
rpsA 1834859 p.Ala440Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102193 p.Arg284Trp missense_variant 1.0
ndh 2103173 c.-132delG upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
katG 2156025 c.87C>A synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168011 p.Ser868Arg missense_variant 1.0
PPE35 2168319 p.Thr765Ile missense_variant 1.0
PPE35 2168814 c.1798dupA frameshift_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223284 c.-120C>T upstream_gene_variant 0.97
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
eis 2715125 p.Thr70Ala missense_variant 1.0
Rv2752c 3066388 c.-197C>T upstream_gene_variant 1.0
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
Rv3083 3448783 p.Val94Ile missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474427 p.Val141Ile missense_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
rpoA 3878630 c.-124delC upstream_gene_variant 1.0
clpC1 4038403 c.2302T>C synonymous_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242680 p.Ala940Ser missense_variant 1.0
embA 4242970 c.-263C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embB 4246551 p.Asn13Ser missense_variant 1.0
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
aftB 4267858 p.Ile327Val missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0