TB-Profiler result

Run: ERR9786640
Summary

Run ID: ERR9786640

Sample name:

Date: 02-04-2023 12:37:15

Number of reads: 1630901

Percentage reads mapped: 99.53

Strain: lineage4.3.2;lineage4.1.2.1;lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.24
lineage4 Euro-American LAM;T;S;X;H None 0.74
lineage4.3 Euro-American (LAM) mainly-LAM None 0.05
lineage4.1 Euro-American T;X;H None 0.64
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.23
lineage4.3.2 Euro-American (LAM) LAM3 None 0.06
lineage4.1.2 Euro-American T;H None 0.65
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.24
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.58
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7595 c.294C>G synonymous_variant 0.77
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.62
fgd1 491742 c.960T>C synonymous_variant 0.32
mshA 575679 p.Asn111Ser missense_variant 0.64
ccsA 620625 p.Ile245Met missense_variant 0.34
rpoB 760115 c.309C>T synonymous_variant 0.64
rpoC 763031 c.-339T>C upstream_gene_variant 0.3
rpoC 765150 p.Gly594Glu missense_variant 0.79
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.27
mmpL5 778061 p.Gln140His missense_variant 0.13
mmpS5 779615 c.-710C>G upstream_gene_variant 0.31
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.3
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472076 n.231G>T non_coding_transcript_exon_variant 0.73
rpsA 1834177 c.636A>C synonymous_variant 0.34
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.21
PPE35 2167926 p.Leu896Ser missense_variant 0.23
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.44
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.27
clpC1 4038287 c.2418C>T synonymous_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.65
embA 4243460 c.228C>T synonymous_variant 0.24
aftB 4267647 p.Asp397Gly missense_variant 0.35
ethA 4326676 p.Ser266Arg missense_variant 0.37
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.21
gid 4407927 p.Glu92Asp missense_variant 0.12