TB-Profiler result

Run: SRR11567801

Summary

Run ID: SRR11567801

Sample name:

Date: 02-04-2023 21:43:15

Number of reads: 10887794

Percentage reads mapped: 99.52

Strain: lineage4.5

Drug-resistance: Pre-XDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7564 p.Gly88Ala missense_variant 0.99 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
gyrA 7582 p.Asp94Ala missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155289 p.Thr275Pro missense_variant 0.99 isoniazid
ahpC 2726145 c.-48G>A upstream_gene_variant 0.98 isoniazid
embB 4248002 p.Gln497Lys missense_variant 0.99 ethambutol
ethA 4326779 c.693_694dupGA frameshift_variant 0.17 ethionamide, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576386 c.1040dupC frameshift_variant 0.98
ccsA 620029 c.139C>T synonymous_variant 0.99
rpoB 761496 p.Tyr564His missense_variant 0.97
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406101 p.Pro414Ser missense_variant 0.99
Rv1258c 1407363 c.-23C>T upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834165 c.624A>G synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170568 p.Ile15Met missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289081 p.Pro54Arg missense_variant 0.99
eis 2715076 p.Ala86Val missense_variant 1.0
Rv2752c 3066155 c.36dupC frameshift_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0
clpC1 4038318 p.Pro796Leu missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ubiA 4269299 p.Ile179Leu missense_variant 0.98
ethA 4326066 p.Arg470Cys missense_variant 0.99
ethA 4326899 p.Pro192Arg missense_variant 0.19
whiB6 4338595 c.-75delG upstream_gene_variant 1.0