Run ID: SRR1180218
Sample name:
Date: 03-04-2023 04:01:43
Number of reads: 7089724
Percentage reads mapped: 99.13
Strain: lineage4.4
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.4 | Euro-American | S;T | None | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.99 | rifampicin |
rpsL | 781687 | p.Lys43Arg | missense_variant | 1.0 | streptomycin |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2288806 | p.Ala146Thr | missense_variant | 0.21 | pyrazinamide |
embB | 4248002 | p.Gln497Lys | missense_variant | 1.0 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
rpoC | 764441 | p.Ile358Val | missense_variant | 1.0 |
rpoC | 764840 | p.Ile491Val | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 0.99 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2168691 | p.Leu641Arg | missense_variant | 0.99 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
pncA | 2288754 | p.Val163Ala | missense_variant | 0.14 |
pncA | 2289162 | p.Leu27Gln | missense_variant | 0.4 |
pepQ | 2859967 | p.Asp151Gly | missense_variant | 1.0 |
Rv2752c | 3065715 | c.477T>C | synonymous_variant | 0.99 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fbiD | 3339662 | p.Trp182* | stop_gained | 0.22 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
embC | 4242462 | p.Gly867Asp | missense_variant | 0.17 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embB | 4247947 | c.1434G>A | synonymous_variant | 1.0 |
aftB | 4268928 | c.-92C>T | upstream_gene_variant | 1.0 |
ubiA | 4269124 | p.Ala237Val | missense_variant | 0.99 |
aftB | 4269375 | c.-539G>A | upstream_gene_variant | 1.0 |
ethA | 4326719 | p.Ala252Phe | missense_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |