TB-Profiler result

Run: SRR14801599
Summary

Run ID: SRR14801599

Sample name:

Date: 03-04-2023 11:54:24

Number of reads: 2289522

Percentage reads mapped: 99.43

Strain: lineage4.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.2 Euro-American H;T;LAM None 0.99
lineage4.2.1 Euro-American (TUR) H3;H4 None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 0.99 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.98 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid
pncA 2288920 p.Gly108Arg missense_variant 1.0 pyrazinamide
eis 2715344 c.-12C>T upstream_gene_variant 1.0 kanamycin
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
embB 4249583 p.Asp1024Asn missense_variant 0.99 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.18
fgd1 491247 c.465C>T synonymous_variant 1.0
mshA 576613 c.1266A>C synonymous_variant 0.2
mshA 576616 c.1269G>C synonymous_variant 0.18
ccsA 619969 p.Val27Ile missense_variant 0.98
rpoC 764367 p.Gly333Ala missense_variant 0.26
rpoC 766467 p.Glu1033Val missense_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.3
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169879 p.Phe245Cys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.25
pepQ 2860159 p.Ala87Gly missense_variant 0.25
Rv2752c 3065952 c.240C>T synonymous_variant 1.0
ald 3086742 c.-78A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.83
fbiD 3339749 p.Val211Ala missense_variant 0.5
fbiD 3339751 p.Ala212Pro missense_variant 0.23
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568428 c.252A>G synonymous_variant 0.5
whiB7 3568431 c.249C>G synonymous_variant 0.33
rpoA 3878590 c.-83G>C upstream_gene_variant 0.18
rpoA 3878597 c.-90G>C upstream_gene_variant 0.55
rpoA 3878637 c.-130G>C upstream_gene_variant 0.4
rpoA 3878640 c.-133G>C upstream_gene_variant 0.22
rpoA 3878641 c.-134C>G upstream_gene_variant 0.5
embC 4240409 p.Pro183Ala missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.27
embB 4247016 p.Ser168Trp missense_variant 0.24
embB 4247020 c.507C>G synonymous_variant 0.19
embB 4248328 c.1815G>C synonymous_variant 0.27
embB 4249594 c.3081G>A synonymous_variant 0.99
ethA 4326632 p.His281Pro missense_variant 0.99
ethA 4328376 c.-903G>C upstream_gene_variant 0.95
whiB6 4338200 p.Asp108His missense_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0