TB-Profiler result

Run: SRR14801601

Summary

Run ID: SRR14801601

Sample name:

Date: 03-04-2023 11:54:47

Number of reads: 6536685

Percentage reads mapped: 99.44

Strain: lineage4.2.1

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.2 Euro-American H;T;LAM None 0.99
lineage4.2.1 Euro-American (TUR) H3;H4 None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.99 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 0.99 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 0.99 isoniazid
pncA 2288920 p.Gly108Arg missense_variant 0.99 pyrazinamide
eis 2715344 c.-12C>T upstream_gene_variant 0.99 kanamycin
embB 4247431 p.Met306Ile missense_variant 0.99 ethambutol
embB 4249583 p.Asp1024Asn missense_variant 0.99 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.18
fgd1 491247 c.465C>T synonymous_variant 0.99
mshA 576442 p.Cys365Trp missense_variant 0.26
ccsA 619969 p.Val27Ile missense_variant 0.99
rpoC 764367 p.Gly333Ala missense_variant 0.29
rpoC 766467 p.Glu1033Val missense_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.25
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.28
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169879 p.Phe245Cys missense_variant 0.99
PPE35 2170065 p.Ala183Gly missense_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.16
Rv2752c 3065952 c.240C>T synonymous_variant 0.99
ald 3086742 c.-78A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.55
fbiD 3339751 p.Ala212Pro missense_variant 0.15
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568428 c.252A>G synonymous_variant 0.39
whiB7 3568431 c.249C>G synonymous_variant 0.24
rpoA 3878613 c.-106A>C upstream_gene_variant 0.2
rpoA 3878637 c.-130G>C upstream_gene_variant 0.36
rpoA 3878641 c.-134C>G upstream_gene_variant 0.7
embC 4240409 p.Pro183Ala missense_variant 0.34
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.52
embB 4247016 p.Ser168Trp missense_variant 0.21
embB 4247020 c.507C>G synonymous_variant 0.24
embB 4248328 c.1815G>C synonymous_variant 0.16
embB 4249594 c.3081G>A synonymous_variant 0.99
ethA 4326632 p.His281Pro missense_variant 1.0
ethA 4328376 c.-903G>C upstream_gene_variant 0.98
whiB6 4338595 c.-75delG upstream_gene_variant 1.0