TB-Profiler result

Run: SRR17658565
Summary

Run ID: SRR17658565

Sample name:

Date: 2024-10-05T14:25:02.338085

Number of reads: 3942034

Percentage reads mapped: 77.57

Median coverage: 106.0

Strain: lineage3

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser431Cys Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 0.91 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
rpoB 761097 p.Ser431Cys missense_variant 0.16 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 633 c.633T>G synonymous_variant 0.16 isoniazid
dnaA 711 c.711C>G synonymous_variant 0.16 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>A synonymous_variant 0.15 isoniazid
gyrB 6217 c.978G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7502 c.201C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8324 c.1023T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8852 c.1551T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8873 c.1572A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8894 c.1593C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8900 c.1599G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8982 p.Cys561Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9154 p.Thr618Asn missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9233 c.1932C>A synonymous_variant 0.15 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491043 c.261T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491077 p.Asn99Asp missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491133 c.351A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491166 c.384G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575576 c.229C>T synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575587 c.240C>G synonymous_variant 0.16 isoniazid
ethionamide
mshA 575590 c.243T>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575629 c.282A>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575632 c.285G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575635 c.288A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide
mshA 575638 c.291T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575649 p.Val101Ala missense_variant 0.24 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.25 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575695 c.348C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.2 isoniazid
ethionamide
mshA 575728 c.381C>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.2 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575770 c.423G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.22 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575786 p.Tyr147His missense_variant 0.22 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575824 c.477T>A synonymous_variant 0.25 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575902 c.555C>T synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575914 c.567C>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575916 p.Asp190Ala missense_variant 0.28 isoniazid
ethionamide
mshA 575925 p.Gly193Ala missense_variant 0.26 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575953 c.606G>C synonymous_variant 0.3 isoniazid
ethionamide
mshA 575959 c.612G>A synonymous_variant 0.28 isoniazid
ethionamide
mshA 575980 c.633T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575984 c.637T>C synonymous_variant 0.17 isoniazid
ethionamide
ccsA 619540 c.-351C>G upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 619551 c.-340A>T upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 619573 c.-318G>C upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>G upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619655 c.-236A>G upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619669 c.-222G>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619672 c.-219A>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619681 c.-210G>T upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619697 c.-194_-192delAGGinsCGC upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619714 c.-177G>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619715 c.-176C>A upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619718 c.-173A>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619723 c.-168G>C upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619727 c.-164A>G upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619729 c.-161_-159delACC upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619735 c.-156G>C upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619744 c.-147A>G upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619748 c.-143G>A upstream_gene_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
ccsA 619753 c.-138G>A upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619762 c.-129C>G upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619766 c.-125A>G upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620245 p.Leu119Met missense_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620643 c.753C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620758 p.Arg290Ser missense_variant 0.15 kanamycin
capreomycin
amikacin
Rv0565c 656466 c.1005G>A synonymous_variant 0.15 ethionamide
Rv0565c 656495 p.Ala326Thr missense_variant 0.14 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.17 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
Rv0565c 656514 c.957C>T synonymous_variant 0.17 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.93 ethionamide Not assoc w R - Interim
Rv0565c 657140 p.Ala111Ser missense_variant 0.14 ethionamide
Rv0565c 657144 c.327T>C synonymous_variant 0.15 ethionamide
Rv0565c 657187 p.His95Arg missense_variant 0.17 ethionamide
Rv0565c 657189 c.282C>G synonymous_variant 0.17 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.17 ethionamide
Rv0565c 657199 p.Thr91Val missense_variant 0.17 ethionamide
Rv0565c 657201 c.270C>G synonymous_variant 0.17 ethionamide
Rv0565c 657220 p.Ala84Val missense_variant 0.24 ethionamide
Rv0565c 657233 p.Ile80Val missense_variant 0.23 ethionamide
Rv0565c 657240 p.Glu77Lys missense_variant 0.2 ethionamide
Rv0565c 657243 c.228C>A synonymous_variant 0.2 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.22 ethionamide
Rv0565c 657261 c.210C>A synonymous_variant 0.22 ethionamide Not assoc w R - Interim
Rv0565c 657264 c.207T>C synonymous_variant 0.22 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.21 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.22 ethionamide
Rv0565c 657294 c.177C>T synonymous_variant 0.21 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.19 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.16 ethionamide Uncertain significance
hadA 731710 c.-220A>T upstream_gene_variant 0.16 isoniazid
nusG 734176 c.-78G>T upstream_gene_variant 0.16 rifampicin
nusG 734183 c.-71C>T upstream_gene_variant 0.16 rifampicin
nusG 734205 c.-49A>C upstream_gene_variant 0.17 rifampicin
nusG 734208 c.-46T>C upstream_gene_variant 0.17 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.16 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.18 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.2 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.22 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.24 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.24 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.25 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.32 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.18 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.16 rifampicin
nusG 734742 c.489T>C synonymous_variant 0.18 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.2 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.21 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.22 rifampicin
nusG 734761 p.Ala170Thr missense_variant 0.23 rifampicin Uncertain significance
nusG 734772 c.519G>C synonymous_variant 0.23 rifampicin
nusG 734778 c.525G>A synonymous_variant 0.22 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.22 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.22 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.24 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.23 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.26 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.27 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.27 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.22 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.2 rifampicin
nusG 734862 c.609C>G synonymous_variant 0.2 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.2 rifampicin
mmaA3 737607 c.543G>A synonymous_variant 0.15 isoniazid
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760307 c.501T>G synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.17 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.18 rifampicin
rpoB 760343 c.537G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.18 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.17 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.26 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243His missense_variant 0.25 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.2 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.21 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.21 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.25 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.25 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.23 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.21 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.21 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.18 rifampicin
rpoB 760781 c.975G>C synonymous_variant 0.17 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761018 c.1212G>A synonymous_variant 0.2 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.2 rifampicin
rpoB 761373 p.Val523His missense_variant 0.18 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.25 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.25 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.25 rifampicin
rpoB 761439 p.Asp545Ser missense_variant 0.24 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.25 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.24 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.24 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.24 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.24 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.25 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.26 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.29 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.29 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.24 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.21 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.24 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.16 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.17 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.16 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.15 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.16 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.22 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.27 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.25 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.24 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.25 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.25 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.47 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.51 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.51 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.51 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.36 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.36 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.28 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.28 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.24 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.24 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.23 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.23 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.24 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.76 rifampicin Not assoc w R
rpoC 762446 c.-924C>G upstream_gene_variant 0.22 rifampicin
rpoB 762490 p.Val895Asp missense_variant 0.16 rifampicin
rpoC 762749 c.-621C>G upstream_gene_variant 0.18 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.18 rifampicin
rpoC 762776 c.-594C>G upstream_gene_variant 0.22 rifampicin
rpoB 762780 p.Gly992Asn missense_variant 0.22 rifampicin
rpoB 762785 p.Asp993Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 762789 p.Leu995Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.24 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.26 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.2 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.24 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.23 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.19 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.19 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763426 c.57C>T synonymous_variant 0.25 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.29 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.24 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.18 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.17 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.18 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.19 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.18 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.17 rifampicin
rpoC 763996 c.627T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.16 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.18 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.18 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.17 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764381 p.Ser338Thr missense_variant 0.15 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.21 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.18 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.2 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.23 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.21 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.19 rifampicin
rpoC 764585 c.1216_1218delCTCinsTTG synonymous_variant 0.2 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>G synonymous_variant 0.26 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.29 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.2 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.17 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.19 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.17 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765053 p.Ser562Thr missense_variant 0.16 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.15 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765364 p.Glu665Asp missense_variant 0.21 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765394 c.2025G>A synonymous_variant 0.23 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.2 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.31 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.31 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.34 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.26 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.25 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.26 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.26 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.31 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.25 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765899 c.2530C>T synonymous_variant 0.24 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.24 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.22 rifampicin
rpoC 766061 p.Val898Leu missense_variant 0.2 rifampicin
rpoC 766083 p.Ala905Glu missense_variant 0.15 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.16 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.17 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.24 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.27 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.27 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.29 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.29 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.3 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.36 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.33 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.3 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.33 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.34 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.32 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.29 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.28 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.28 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.24 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.22 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.22 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.22 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.22 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.24 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.25 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.26 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.29 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.27 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.27 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.29 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.27 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.25 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.27 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.22 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.3 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.31 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.31 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.3 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.34 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.31 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.31 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767110 c.3741T>C synonymous_variant 0.26 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.21 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.2 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767181 p.Ala1271Glu missense_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775909 p.Leu858Phe missense_variant 0.15 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776181 p.Asp767Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781568 c.9C>G synonymous_variant 0.16 streptomycin
rpsL 781571 c.12C>T synonymous_variant 0.16 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.22 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.22 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.21 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.28 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.27 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.28 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.28 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.28 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.29 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.27 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.26 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.25 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.28 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.23 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.24 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800546 c.-263T>A upstream_gene_variant 0.17 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.17 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.19 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.19 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.21 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.27 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.26 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.22 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.21 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.2 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.14 linezolid
rplC 800937 c.129A>G synonymous_variant 0.17 linezolid
rplC 800946 c.138T>C synonymous_variant 0.17 linezolid
rplC 800949 c.141T>C synonymous_variant 0.17 linezolid
Rv1129c 1253182 p.Asn451Lys missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303812 c.882C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303842 c.912C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303855 p.Ala309Thr missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303869 c.939T>C synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303881 c.951G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303887 c.957G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303897 c.967C>T synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303908 c.978C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303938 c.1008C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304481 c.1551T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304484 c.1554C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304493 p.Asp521Glu missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304496 c.1566T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304530 p.Ser534Ala missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304538 c.1608C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304604 c.1674C>T synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304634 c.1704C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304931 c.2001C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304991 c.2061G>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305006 p.Glu692Asp missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>A synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305093 c.2163C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305113 p.Asp728Gly missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305117 c.2187T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305126 c.2196T>C synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1305331 p.Glu801Lys missense_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1305348 c.2418C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
sigE 1364712 c.300T>C synonymous_variant 0.17 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.18 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.18 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.19 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
sigE 1364739 c.327C>G synonymous_variant 0.19 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.19 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.19 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.16 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.14 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.17 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.18 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.18 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.18 pyrazinamide
sigE 1364895 p.Glu161Asp missense_variant 0.18 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.2 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.25 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.22 pyrazinamide
sigE 1364958 c.546G>C synonymous_variant 0.22 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.21 pyrazinamide
sigE 1364964 c.552T>G synonymous_variant 0.21 pyrazinamide
sigE 1364976 c.564T>G synonymous_variant 0.19 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.18 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.16 pyrazinamide
atpE 1460816 c.-229T>C upstream_gene_variant 0.18 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.18 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.19 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.2 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.2 bedaquiline
atpE 1460879 c.-166C>G upstream_gene_variant 0.2 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.19 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.15 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.16 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.22 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.2 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474071 n.414G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid Uncertain significance
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673799 c.-403T>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673808 c.-394A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673838 c.-364T>C upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673841 c.-361A>C upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673844 c.-358G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673856 c.-346T>G upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673870 c.-332G>T upstream_gene_variant 0.14 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673988 c.-214G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674399 c.198A>G synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674450 c.249G>T synonymous_variant 0.14 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674483 c.282G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.23 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.24 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674639 c.438C>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674726 c.525G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674750 c.549T>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674759 c.558G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674780 c.579T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674783 c.582C>T synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674790 c.589C>T synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674799 c.598_600delAGTinsTCG synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.22 isoniazid
ethionamide
inhA 1674858 c.657G>A synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674879 c.678T>G synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674924 c.723G>A synonymous_variant 0.15 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.14 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833610 c.69C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833949 c.408T>G synonymous_variant 0.22 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834636 c.1095C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.17 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.26 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.3 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.29 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.26 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.25 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.26 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.24 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.22 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.21 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.17 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.16 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517941 c.-174C>G upstream_gene_variant 0.18 isoniazid
kasA 2518439 p.Ala109Ser missense_variant 0.14 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.18 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.22 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.22 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.22 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.21 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.21 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.23 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.22 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.23 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.23 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.24 isoniazid
kasA 2518594 c.480C>G synonymous_variant 0.26 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.26 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.26 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.28 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.24 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.24 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.27 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.27 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.27 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.23 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.23 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.19 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.2 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.18 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
folC 2746999 c.600T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747002 c.597T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747007 p.Ser198Gly missense_variant 0.18 para-aminosalicylic_acid
folC 2747010 p.Ile197Val missense_variant 0.22 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747026 c.573C>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747032 c.567A>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747040 p.Ile187Val missense_variant 0.23 para-aminosalicylic_acid
folC 2747041 c.558G>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747053 c.546C>T synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747059 c.540T>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747062 c.537A>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747074 c.525G>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747083 c.516G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747086 c.513A>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782495 p.Asp516Glu missense_variant 0.25 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
amikacin Uncertain significance
Rv2477c 2782498 c.1545C>T synonymous_variant 0.74 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782501 c.1542T>C synonymous_variant 0.29 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782510 c.1533G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782582 p.Asn487Lys missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782586 p.Leu486Glu missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782591 c.1452T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.34 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783080 c.963G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>A synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783098 c.945C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783107 c.936G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783476 c.567C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783590 c.453G>A synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783764 p.Met93Leu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783767 c.276C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783791 c.252C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783800 c.243G>A synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783842 c.201C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783854 c.189C>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.19 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
pepQ 2859873 c.546T>C synonymous_variant 0.15 bedaquiline
clofazimine
pepQ 2859885 c.534C>G synonymous_variant 0.18 bedaquiline
clofazimine
pepQ 2859908 p.Gln171Glu missense_variant 0.21 bedaquiline
clofazimine
pepQ 2859909 c.510G>C synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859921 c.498C>G synonymous_variant 0.22 bedaquiline
clofazimine
pepQ 2859924 c.495G>C synonymous_variant 0.22 bedaquiline
clofazimine
pepQ 2859933 c.486C>T synonymous_variant 0.23 bedaquiline
clofazimine
pepQ 2859939 c.480C>G synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859942 p.Ala159Glu missense_variant 0.22 bedaquiline
clofazimine
pepQ 2859950 c.469T>C synonymous_variant 0.2 bedaquiline
clofazimine
pepQ 2859956 p.Thr155Ala missense_variant 0.21 bedaquiline
clofazimine
pepQ 2859957 c.462G>C synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859966 c.453T>C synonymous_variant 0.22 bedaquiline
clofazimine
pepQ 2859972 c.447A>G synonymous_variant 0.22 bedaquiline
clofazimine
pepQ 2859975 c.444A>G synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859984 c.435A>G synonymous_variant 0.2 bedaquiline
clofazimine
pepQ 2859987 c.432A>G synonymous_variant 0.17 bedaquiline
clofazimine
Rv2680 2996009 c.-96T>C upstream_gene_variant 0.96 capreomycin Uncertain significance
Rv2752c 3065866 p.Leu109Trp missense_variant 0.87 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
thyX 3067532 c.414C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067553 c.393C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067586 c.360C>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067619 c.327A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067622 c.324C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067680 p.Cys89Leu missense_variant 0.27 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067733 c.213G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067745 c.201C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.27 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.28 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067784 c.162C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067796 c.150C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067823 c.123G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067839 p.Val36Thr missense_variant 0.17 para-aminosalicylic_acid
thyX 3067841 c.105G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067853 c.93C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073896 c.576C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3569139 c.-460C>T upstream_gene_variant 1.0 kanamycin
amikacin
streptomycin
lpqB 3624107 c.804C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624656 c.255C>T synonymous_variant 0.13 rifampicin
bedaquiline
lpqB 3624680 c.231T>G synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.17 rifampicin
bedaquiline
lpqB 3624728 c.183C>T synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 0.99 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625089 p.Ala509Ser missense_variant 0.15 rifampicin
bedaquiline
lpqB 3625090 c.-180C>A upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625135 c.-225A>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625147 c.-237C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.2 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625792 c.-882G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626124 p.Ala164Ser missense_variant 0.15 rifampicin
bedaquiline
mtrB 3626146 c.468C>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3626157 p.Ala153Ser missense_variant 0.17 rifampicin
bedaquiline
mtrB 3626190 p.Ser142Thr missense_variant 0.15 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626735 c.-122C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGT upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626924 c.-311G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627277 c.73C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.16 rifampicin
bedaquiline
fbiB 3640914 c.-621C>G upstream_gene_variant 0.16 pretomanid
delamanid
clofazimine
fbiA 3640930 p.Glu130Lys missense_variant 0.15 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiB 3640944 c.-591T>C upstream_gene_variant 0.16 pretomanid
delamanid
clofazimine
fbiA 3641286 c.744C>T synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiA 3641288 p.Glu249Gly missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3641292 c.-243G>A upstream_gene_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3641295 c.-240G>C upstream_gene_variant 0.17 pretomanid
delamanid
clofazimine
fbiA 3641314 p.Thr258Ala missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3641322 c.-213T>G upstream_gene_variant 0.16 pretomanid
delamanid
clofazimine
fbiA 3641340 p.Asp266Glu missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiA 3641351 p.Ala270Asp missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiB 3641373 c.-162C>G upstream_gene_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3641379 c.-156G>C upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fbiA 3641380 p.Cys280Arg missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiA 3641384 p.Ala281Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiA 3641394 c.852A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiB 3641609 c.75C>A synonymous_variant 0.14 pretomanid
delamanid
clofazimine
alr 3841001 c.420A>G synonymous_variant 0.16 cycloserine
alr 3841017 p.Leu135Gln missense_variant 0.16 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.17 cycloserine
alr 3841028 c.393G>C synonymous_variant 0.17 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.17 cycloserine
alr 3841036 p.Gln129Glu missense_variant 0.17 cycloserine
alr 3841058 p.Gly121Arg missense_variant 0.17 cycloserine
alr 3841590 c.-170G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.21 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.21 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.2 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>T synonymous_variant 0.15 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.26 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.31 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.32 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.35 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.34 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.34 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.37 rifampicin
rpoA 3878067 c.441C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.36 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.36 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.36 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.37 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.37 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.36 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.3 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.29 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.28 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.28 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.2 rifampicin
rpoA 3878284 p.Glu75Ala missense_variant 0.24 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.22 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.22 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.23 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.22 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.21 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.19 rifampicin
rpoA 3878430 c.78G>C synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.18 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878722 c.-215C>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878725 c.-218A>C upstream_gene_variant 0.26 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.29 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.27 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.29 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.34 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.34 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.33 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.38 rifampicin
rpoA 3878950 c.-443C>G upstream_gene_variant 0.37 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.38 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.38 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.4 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.37 rifampicin
rpoA 3879043 c.-536C>G upstream_gene_variant 0.38 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.3 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879115 c.-608G>A upstream_gene_variant 0.3 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.33 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.28 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.2 pretomanid
delamanid
clpC1 4038299 c.2406C>A synonymous_variant 0.14 pyrazinamide
clpC1 4038310 p.Val799Met missense_variant 0.17 pyrazinamide
clpC1 4038314 c.2391T>A synonymous_variant 0.17 pyrazinamide
clpC1 4038320 c.2385G>A synonymous_variant 0.15 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.17 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.25 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.25 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.23 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039316 c.1389G>A synonymous_variant 0.15 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.22 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.39 pyrazinamide Uncertain significance
clpC1 4039582 p.Thr375Ser missense_variant 0.36 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039814 c.891C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039832 c.873C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039919 c.786C>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.21 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040108 c.597G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.31 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.3 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.2 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.16 pyrazinamide
panD 4044150 c.132A>G synonymous_variant 0.18 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.2 pyrazinamide
panD 4044737 c.-456T>G upstream_gene_variant 0.24 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
panD 4044954 c.-673C>T upstream_gene_variant 0.14 pyrazinamide
panD 4044972 c.-691A>G upstream_gene_variant 0.2 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.21 pyrazinamide
panD 4044995 c.-714A>G upstream_gene_variant 0.22 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.21 pyrazinamide
panD 4045022 c.-742_-741delTCinsCG upstream_gene_variant 0.2 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.21 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045055 c.-774T>C upstream_gene_variant 0.16 pyrazinamide
glpK 4138451 c.1305T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138471 p.Ile429Val missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138568 c.1188A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138610 c.1146C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138622 c.1134C>T synonymous_variant 0.81 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138634 c.1122G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138696 p.Pro354Ala missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138754 c.1002C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138772 p.Ser328Ala missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238969 c.-894A>G upstream_gene_variant 0.21 ethambutol
embC 4238972 c.-891C>G upstream_gene_variant 0.2 ethambutol Uncertain significance
embC 4238975 c.-888A>C upstream_gene_variant 0.2 ethambutol
embC 4238986 c.-877_-876delCAinsTG upstream_gene_variant 0.19 ethambutol
embC 4238999 c.-864C>G upstream_gene_variant 0.17 ethambutol Uncertain significance
embC 4239012 c.-851_-849delTCCinsACG upstream_gene_variant 0.2 ethambutol
embC 4239020 c.-843G>C upstream_gene_variant 0.21 ethambutol
embC 4239023 c.-840C>G upstream_gene_variant 0.22 ethambutol
embC 4239027 c.-836A>G upstream_gene_variant 0.21 ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 0.21 ethambutol Uncertain significance
embC 4239057 c.-806A>G upstream_gene_variant 0.2 ethambutol
embC 4239068 c.-795A>G upstream_gene_variant 0.2 ethambutol
embC 4239071 c.-792A>G upstream_gene_variant 0.2 ethambutol Uncertain significance
embC 4239076 c.-787C>T upstream_gene_variant 0.2 ethambutol
embC 4239079 c.-784_-783delCAinsGG upstream_gene_variant 0.2 ethambutol
embC 4239083 c.-780C>G upstream_gene_variant 0.21 ethambutol
embC 4239116 c.-747C>T upstream_gene_variant 0.14 ethambutol Uncertain significance
embC 4240819 c.957A>G synonymous_variant 0.16 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.16 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.16 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.19 ethambutol
embC 4241116 c.1254C>G synonymous_variant 0.22 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Ala missense_variant 0.23 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.23 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.22 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.19 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embB 4245665 c.-849C>G upstream_gene_variant 0.19 ethambutol
embB 4245668 c.-846C>G upstream_gene_variant 0.2 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4245680 c.-834G>A upstream_gene_variant 0.23 ethambutol
embA 4245688 p.Val819Ala missense_variant 0.23 ethambutol
embB 4245692 c.-822G>C upstream_gene_variant 0.23 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.23 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.22 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.2 ethambutol
embB 4245726 c.-788_-786delTTGinsCTC upstream_gene_variant 0.2 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.19 ethambutol
embB 4245740 c.-774T>G upstream_gene_variant 0.2 ethambutol
embB 4245755 c.-759C>G upstream_gene_variant 0.18 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.16 ethambutol
embA 4245771 p.Asn847Tyr missense_variant 0.15 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.15 ethambutol
embB 4247857 c.1344C>G synonymous_variant 0.17 ethambutol
embB 4247858 c.1345C>T synonymous_variant 0.16 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.24 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247896 c.1383G>C synonymous_variant 0.24 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.23 ethambutol
embB 4247905 c.1392G>A synonymous_variant 0.22 ethambutol
embB 4247909 c.1396_1398delTTGinsCTC synonymous_variant 0.21 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247920 c.1407T>G synonymous_variant 0.21 ethambutol
embB 4247923 c.1410T>C synonymous_variant 0.21 ethambutol
embB 4247926 c.1413C>G synonymous_variant 0.21 ethambutol
embB 4247938 c.1425G>C synonymous_variant 0.23 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.23 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.27 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247962 c.1449G>C synonymous_variant 0.28 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.29 ethambutol
embB 4248001 c.1488C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.22 ethambutol
embB 4248019 c.1506G>C synonymous_variant 0.19 ethambutol
embB 4248025 c.1512A>G synonymous_variant 0.18 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248055 c.1542G>C synonymous_variant 0.19 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.18 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.2 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.2 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.2 ethambutol
embB 4248313 c.1800C>G synonymous_variant 0.17 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.17 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.17 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.17 ethambutol
embB 4248325 c.1812G>C synonymous_variant 0.17 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.17 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.16 ethambutol
embB 4248362 p.Ser617Lys missense_variant 0.14 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.17 ethambutol
aftB 4268719 p.Asn40Asp missense_variant 0.94 ethambutol Uncertain significance
ubiA 4269075 p.Ile253Val missense_variant 0.15 ethambutol
aftB 4269096 c.-260C>G upstream_gene_variant 0.17 ethambutol
ubiA 4269099 c.735G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4269103 c.-268_-267delAGinsTC upstream_gene_variant 0.17 ethambutol
ubiA 4269107 p.Tyr243His missense_variant 0.17 ethambutol
ubiA 4269110 p.Gly242Arg missense_variant 0.17 ethambutol
aftB 4269114 c.-278C>T upstream_gene_variant 0.18 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.18 ethambutol
ubiA 4269131 c.703C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
aftB 4269143 c.-307T>C upstream_gene_variant 0.18 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
ubiA 4269164 p.Leu224Met missense_variant 0.17 ethambutol
aftB 4269165 c.-329G>C upstream_gene_variant 0.17 ethambutol
aftB 4269174 c.-338C>T upstream_gene_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338897 c.-376T>C upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R