TB-Profiler result

Run: SRR18910194
Summary

Run ID: SRR18910194

Sample name:

Date: 2024-10-04T00:38:06.517506

Number of reads: 1139296

Percentage reads mapped: 56.63

Median coverage: 46.0

Strain: lineage2.2.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.94
lineage2.2.2 East-Asian (Beijing) RD105;RD207 0.78
lineage2.2 East-Asian (Beijing) RD105;RD207 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-154G>A Assoc w R Alias fabG1_p.Leu203Leu. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide panD p.Val138Ala Mutation from literature
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-154G>A Assoc w R - Interim Alias fabG1_p.Leu203Leu
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance Mutation from literature
inhA 1674048 c.-154G>A upstream_gene_variant 0.68 ethionamide Assoc w R - Interim Alias fabG1_p.Leu203Leu
isoniazid Assoc w R Alias fabG1_p.Leu203Leu. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
panD 4043869 p.Val138Ala missense_variant 0.2 pyrazinamide Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 534 c.534T>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 537 c.537C>A synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.3 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.3 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.3 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.33 isoniazid
dnaA 582 c.582A>G synonymous_variant 0.3 isoniazid
dnaA 585 c.585A>G synonymous_variant 0.3 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.35 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.34 isoniazid
dnaA 600 c.600T>G synonymous_variant 0.35 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.34 isoniazid
dnaA 645 c.645A>T synonymous_variant 0.33 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.29 isoniazid
dnaA 657 c.657C>T synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 660 c.660G>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.29 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.27 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.27 isoniazid
dnaA 682 c.682_684delTTGinsCTC synonymous_variant 0.28 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.33 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.32 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.36 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.36 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.36 isoniazid
dnaA 771 c.771A>T synonymous_variant 0.36 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.37 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.36 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.36 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.34 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.33 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.31 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.3 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.3 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.31 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.31 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.33 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.32 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.37 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.4 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.37 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.36 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.39 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.39 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.38 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.38 isoniazid
dnaA 954 c.954G>C synonymous_variant 0.4 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.44 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.44 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.44 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.48 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.4 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 999 c.999C>G synonymous_variant 0.4 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.45 isoniazid
dnaA 1032 c.1032G>A synonymous_variant 0.44 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.45 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.45 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.48 isoniazid
dnaA 1059 c.1059C>G synonymous_variant 0.47 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.45 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.49 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.48 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.51 isoniazid
dnaA 1116 c.1116C>G synonymous_variant 0.51 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.52 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.52 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.51 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.47 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.47 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.44 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 1170 c.1170C>T synonymous_variant 0.46 isoniazid
dnaA 1176 c.1176A>G synonymous_variant 0.46 isoniazid
dnaA 1179 c.1179G>T synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 1185 c.1185C>G synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 1188 c.1188G>A synonymous_variant 0.43 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.44 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.45 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.46 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.43 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.35 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.37 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.37 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.35 isoniazid
dnaA 1257 c.1257C>T synonymous_variant 0.35 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.34 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.28 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.27 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.25 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.26 isoniazid
dnaA 1311 c.1311C>G synonymous_variant 0.25 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.26 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.26 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.25 isoniazid
dnaA 1347 c.1347C>T synonymous_variant 0.25 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.19 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1371 c.1371T>G synonymous_variant 0.19 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.2 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.19 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.2 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.21 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.2 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.2 isoniazid
gyrB 6130 c.891T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6178 c.939C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6193 c.954G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6214 c.975G>A synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6223 c.984G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6229 c.990G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6247 c.1008G>A synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6262 c.1023G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6334 c.-968G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6559 c.-743C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6565 c.-737G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6580 c.-722C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6589 c.-713G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.45 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.43 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6850 c.1611C>A synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6931 c.-371A>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6941 c.-361C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6950 c.-352_-350delCTCinsTTG upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6997 c.-305G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8129 c.828T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8315 c.1014G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8360 c.1059G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8367 c.1066C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364Leu missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8429 c.1128C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.54 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.55 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8972 c.1671C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.36 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9032 c.1731T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9068 c.1767G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9077 c.1776C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9128 c.1827C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.38 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9261 c.1960_1962delCGCinsAGA synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9266 c.1965C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCGC synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
Rv0010c 13897 c.-339C>T upstream_gene_variant 0.19 isoniazid
fgd1 491031 c.249C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491085 c.303T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491088 c.306C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fgd1 491112 c.330G>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fgd1 491137 p.Glu119Gln missense_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 491166 c.384G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491172 c.390C>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491184 c.402A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491223 c.441C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491226 c.444C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491229 c.447C>T synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491277 c.495G>A synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491283 p.Asp167Glu missense_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.42 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491296 p.Val172Ile missense_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491302 p.Ile174Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491331 c.549G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491337 c.555C>G synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491349 c.567T>C synonymous_variant 0.38 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491355 c.573C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575803 c.456C>T synonymous_variant 0.33 isoniazid Not assoc w R - Interim
ethionamide
mshA 575806 c.459G>C synonymous_variant 0.33 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.36 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.34 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575872 c.525C>T synonymous_variant 0.29 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.23 isoniazid
ethionamide
mshA 575920 c.573C>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575950 c.603C>G synonymous_variant 0.2 isoniazid
ethionamide
ccsA 619634 c.-257T>A upstream_gene_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 619645 c.-246G>C upstream_gene_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>G upstream_gene_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 619668 c.-223C>G upstream_gene_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 619672 c.-219A>T upstream_gene_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 619697 c.-194_-192delAGGinsCGC upstream_gene_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620226 c.336G>A synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620245 c.355T>C synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620256 c.366C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620301 c.411G>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620397 c.507C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620404 c.514C>T synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620409 c.519C>G synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620442 c.552G>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620598 c.708C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620613 c.723C>A synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620622 c.732G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620631 c.741T>G synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>G synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620766 c.876C>G synonymous_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620787 c.897C>A synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620790 c.900C>T synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620796 c.906C>G synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620808 c.918T>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620823 c.933C>T synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620832 c.942C>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.98 ethionamide Uncertain significance
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.22 ethionamide
Rv0565c 657650 c.-180G>A upstream_gene_variant 0.23 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.3 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.31 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.35 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.38 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.41 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.48 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.44 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.45 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.48 isoniazid
hadA 731708 c.-221_-220delGA upstream_gene_variant 0.49 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.47 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.49 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.52 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.42 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.38 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.46 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.34 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.25 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.2 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.2 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.2 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.2 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.27 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.31 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.37 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.48 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.48 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.48 isoniazid
hadA 732398 p.Ala157Ile missense_variant 0.47 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.23 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.24 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.24 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.25 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.25 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.31 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>T synonymous_variant 0.3 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.27 rifampicin
nusG 734566 c.313C>T synonymous_variant 0.29 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.27 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.28 rifampicin
nusG 734595 c.342C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.25 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.22 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.21 rifampicin
nusG 734680 p.Ala143Thr missense_variant 0.18 rifampicin
mmaA3 738260 c.-117_-112delAATCCC upstream_gene_variant 1.0 isoniazid
rpoB 760112 c.306T>C synonymous_variant 0.2 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.25 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.29 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.32 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.33 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.33 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.32 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760358 c.552C>G synonymous_variant 0.26 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.22 rifampicin
rpoB 760373 c.567C>G synonymous_variant 0.22 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.2 rifampicin
rpoB 760388 c.582C>T synonymous_variant 0.22 rifampicin
rpoB 760389 c.583_584delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.25 rifampicin
rpoB 760412 c.606C>T synonymous_variant 0.25 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760427 c.621G>A synonymous_variant 0.25 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760496 c.690G>C synonymous_variant 0.23 rifampicin
rpoB 760508 c.702G>C synonymous_variant 0.22 rifampicin
rpoB 760519 p.Thr238Ser missense_variant 0.21 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.21 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.42 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.39 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.39 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.46 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.45 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.45 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.44 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.41 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.42 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.29 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.3 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.32 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760835 c.1029delCinsTCACGCCCGTACG conservative_inframe_insertion&synonymous_variant 0.29 rifampicin
rpoB 760838 p.Glu344Asp missense_variant 0.28 rifampicin
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.24 rifampicin
rpoB 760848 p.Thr348Ala missense_variant 0.25 rifampicin
rpoB 760850 c.1044delGinsTGTC conservative_inframe_insertion&synonymous_variant 0.25 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.37 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.4 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.45 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760922 c.1116G>A synonymous_variant 0.49 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.49 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.47 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.52 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.5 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.52 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.49 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.5 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.41 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.4 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761286 c.1480C>T synonymous_variant 0.33 rifampicin
rpoB 761289 p.Ser495Ala missense_variant 0.32 rifampicin
rpoB 761292 p.Val496Thr missense_variant 0.32 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.22 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.23 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.23 rifampicin
rpoB 761434 c.1629_1630delTG frameshift_variant 0.24 rifampicin
rpoB 761440 c.1634_1635delACinsCAAG frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.24 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.24 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.24 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.24 rifampicin
rpoB 761462 c.1656C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761465 c.1659G>C synonymous_variant 0.25 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.26 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.25 rifampicin
rpoB 761507 c.1701G>C synonymous_variant 0.24 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.23 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761843 c.2037C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>T synonymous_variant 0.23 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.22 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.24 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.25 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.24 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.25 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.25 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.29 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.25 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.27 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.4 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.42 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.42 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.48 rifampicin
rpoB 762218 c.2412T>G synonymous_variant 0.41 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.35 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.28 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.27 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.25 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.25 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.3 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.29 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.27 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.29 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.31 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.3 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.3 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.26 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.26 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.26 rifampicin
rpoB 762548 c.2742C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762551 c.-819C>G upstream_gene_variant 0.27 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.58 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.56 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.49 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.54 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.41 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.41 rifampicin
rpoC 763163 c.-207C>G upstream_gene_variant 0.39 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.3 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.3 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.29 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>C upstream_gene_variant 0.3 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.28 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.3 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.3 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.28 rifampicin
rpoC 763304 c.-66_-63delAAGTinsGTCC upstream_gene_variant 0.22 rifampicin
rpoC 763310 c.-60C>T upstream_gene_variant 0.22 rifampicin
rpoC 763319 c.-51T>C upstream_gene_variant 0.24 rifampicin
rpoC 763322 c.-48G>C upstream_gene_variant 0.23 rifampicin
rpoC 763325 c.-44_-37delAGCTGTCG upstream_gene_variant 0.23 rifampicin
rpoC 763337 c.-33_-32delAAinsCGTTTTCAG upstream_gene_variant 0.22 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoC 763402 c.33C>A synonymous_variant 0.39 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.38 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.44 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.47 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.58 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.59 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763663 c.294C>G synonymous_variant 0.58 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.56 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.56 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.52 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.52 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.44 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.42 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.34 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.31 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.29 rifampicin
rpoC 763835 p.Ala156Thr missense_variant 0.32 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.32 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.29 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.27 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.25 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.25 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763909 c.540C>T synonymous_variant 0.31 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.28 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.27 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.23 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.29 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.3 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.3 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.29 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.39 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.41 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.4 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.42 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.46 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.51 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.49 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.53 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.51 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.51 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.54 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.53 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.51 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764368 c.999C>T synonymous_variant 0.26 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.29 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.28 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.28 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.33 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.4 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.4 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.38 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.4 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.39 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.39 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.46 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.47 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.42 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>A synonymous_variant 0.38 rifampicin
rpoC 764858 c.1489_1491delTTGinsCTA synonymous_variant 0.38 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.39 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.33 rifampicin Not assoc w R
rpoC 765005 c.1637_1638insGC frameshift_variant 0.27 rifampicin
rpoC 765010 c.1641_1643delGAGinsC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.28 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.23 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.23 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.23 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765100 c.1731G>C synonymous_variant 0.24 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.24 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.29 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.3 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.33 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.3 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.35 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.33 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.37 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.36 rifampicin
rpoC 765415 c.2046G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.42 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.42 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.46 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.44 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.39 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.4 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.4 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.43 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.4 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.39 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.43 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.43 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.42 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.42 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.43 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.41 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.46 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.39 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.31 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.31 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.3 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.33 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.34 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.32 rifampicin
rpoC 766087 c.2718C>G synonymous_variant 0.33 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.33 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.31 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.32 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766174 p.Asn935Lys missense_variant 0.24 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.24 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.28 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766193 p.Gln942Glu missense_variant 0.23 rifampicin
rpoC 766204 c.2835C>T synonymous_variant 0.25 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.25 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766219 p.Asp950Glu missense_variant 0.24 rifampicin
rpoC 766222 c.2853T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766226 c.2857T>C synonymous_variant 0.26 rifampicin
rpoC 766231 c.2862T>G synonymous_variant 0.26 rifampicin
rpoC 766234 c.2865T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766237 c.2868T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.25 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.24 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.26 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.3 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.32 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.32 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.36 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.48 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.51 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.46 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.47 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.43 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.43 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.42 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.43 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.45 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.44 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.44 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.53 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.57 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.54 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.48 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.47 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.53 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.53 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.52 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.52 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.51 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.48 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.49 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.49 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.49 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.5 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.55 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.59 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.54 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.55 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.51 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.53 rifampicin
rpoC 766684 c.3315C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766726 c.3357T>C synonymous_variant 0.5 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.52 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.4 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.34 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.35 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.34 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.34 rifampicin
rpoC 766933 c.3564A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.46 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.51 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.54 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.5 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.51 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767128 c.3759C>T synonymous_variant 0.44 rifampicin
rpoC 767134 c.3765C>A synonymous_variant 0.44 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.25 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpS5 778656 p.Ala84Thr missense_variant 1.0 bedaquiline
clofazimine
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781134 c.-426T>A upstream_gene_variant 0.25 streptomycin
rpsL 781137 c.-423G>C upstream_gene_variant 0.25 streptomycin
rpsL 781138 c.-422_-421delCAinsGC upstream_gene_variant 0.25 streptomycin
rpsL 781143 c.-417T>C upstream_gene_variant 0.26 streptomycin
rpsL 781158 c.-402C>G upstream_gene_variant 0.27 streptomycin
rpsL 781161 c.-399G>A upstream_gene_variant 0.27 streptomycin
rpsL 781164 c.-396T>C upstream_gene_variant 0.27 streptomycin
rpsL 781173 c.-387A>G upstream_gene_variant 0.27 streptomycin
rpsL 781179 c.-381T>C upstream_gene_variant 0.28 streptomycin
rpsL 781182 c.-378G>C upstream_gene_variant 0.29 streptomycin
rpsL 781185 c.-375T>C upstream_gene_variant 0.29 streptomycin
rpsL 781197 c.-363A>G upstream_gene_variant 0.31 streptomycin
rpsL 781206 c.-354C>T upstream_gene_variant 0.29 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781406 c.-154_-153insC upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.29 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.34 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.36 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.43 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.43 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.4 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.41 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.41 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.41 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.41 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.43 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781800 c.241C>T synonymous_variant 0.44 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.45 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.45 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.42 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.41 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.41 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.38 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.41 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.41 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.42 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.43 streptomycin Uncertain significance
rplC 800693 c.-116A>G upstream_gene_variant 0.2 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.23 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.34 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.38 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.35 linezolid
rplC 800797 c.-12_-9delTTGGinsGTT upstream_gene_variant 0.34 linezolid
rplC 800814 c.6A>G synonymous_variant 0.37 linezolid
rplC 800817 c.9A>T synonymous_variant 0.37 linezolid
rplC 800844 c.36T>C synonymous_variant 0.39 linezolid
rplC 800862 c.54C>T synonymous_variant 0.36 linezolid
rplC 800865 c.57A>G synonymous_variant 0.37 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.37 linezolid
rplC 800874 c.66A>G synonymous_variant 0.35 linezolid
rplC 800875 p.Val23Ile missense_variant 0.34 linezolid
rplC 800880 c.72A>G synonymous_variant 0.34 linezolid
rplC 800889 c.81C>G synonymous_variant 0.39 linezolid
rplC 800892 c.84G>C synonymous_variant 0.38 linezolid
rplC 800907 c.99C>G synonymous_variant 0.37 linezolid
rplC 800910 c.102C>T synonymous_variant 0.37 linezolid
rplC 800916 c.108A>G synonymous_variant 0.33 linezolid
rplC 800934 c.126C>G synonymous_variant 0.3 linezolid
rplC 800937 c.129A>G synonymous_variant 0.29 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.29 linezolid
rplC 800946 c.138T>C synonymous_variant 0.28 linezolid
rplC 800949 c.141T>C synonymous_variant 0.28 linezolid
rplC 800958 c.150G>T synonymous_variant 0.29 linezolid
rplC 800967 c.159C>G synonymous_variant 0.31 linezolid
rplC 800970 c.162T>C synonymous_variant 0.32 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.27 linezolid
rplC 800985 c.177A>G synonymous_variant 0.26 linezolid
rplC 801004 p.Leu66Val missense_variant 0.21 linezolid
rplC 801009 c.201A>C synonymous_variant 0.21 linezolid
rplC 801174 c.366T>C synonymous_variant 0.3 linezolid
rplC 801195 c.387G>C synonymous_variant 0.29 linezolid
rplC 801207 c.399C>T synonymous_variant 0.3 linezolid
rplC 801231 c.423C>G synonymous_variant 0.31 linezolid
rplC 801246 c.438C>T synonymous_variant 0.24 linezolid
rplC 801249 c.441T>C synonymous_variant 0.23 linezolid
rplC 801255 c.447C>T synonymous_variant 0.24 linezolid
rplC 801264 c.456C>T synonymous_variant 0.2 linezolid
rplC 801267 c.459A>T synonymous_variant 0.24 linezolid
rplC 801270 c.462T>C synonymous_variant 0.26 linezolid
rplC 801276 c.468G>C synonymous_variant 0.25 linezolid
rplC 801279 c.471G>C synonymous_variant 0.23 linezolid
rplC 801282 c.474G>C synonymous_variant 0.23 linezolid
rplC 801285 c.477G>C synonymous_variant 0.24 linezolid
rplC 801300 c.492C>G synonymous_variant 0.26 linezolid
rplC 801309 c.501C>G synonymous_variant 0.26 linezolid
rplC 801312 c.504G>C synonymous_variant 0.26 linezolid
rplC 801321 c.513C>T synonymous_variant 0.28 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.28 linezolid
rplC 801339 c.531T>C synonymous_variant 0.29 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.3 linezolid
rplC 801348 c.540T>G synonymous_variant 0.28 linezolid
rplC 801357 c.549T>C synonymous_variant 0.27 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.24 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.22 linezolid
rplC 801423 c.615G>C synonymous_variant 0.25 linezolid
rplC 801426 c.618C>G synonymous_variant 0.26 linezolid
rplC 801427 p.Met207Val missense_variant 0.26 linezolid
rplC 801438 c.630T>C synonymous_variant 0.3 linezolid
rplC 801442 p.Ile212Val missense_variant 0.29 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303538 p.Arg203Leu missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303596 c.666G>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303620 c.690C>T synonymous_variant 0.25 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303623 c.693C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303626 c.696C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303641 c.711C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303650 c.720G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303653 c.723G>A synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303654 c.724C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303659 c.729T>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303660 p.Val244Thr missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303663 c.733C>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303674 c.744C>G synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1303677 c.747C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.66 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1303722 c.792C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Gly missense_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303740 c.810C>T synonymous_variant 0.32 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303749 c.819G>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.56 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303779 c.849G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303812 c.882C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303825 p.Glu299Gln missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303833 c.903C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303844 p.Ala305Gly missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303851 c.921C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303866 c.936G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303872 c.942C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303873 c.943C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303878 c.948G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303882 p.Val318Met missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303893 c.963G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1303944 c.1014G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303953 p.Asp341Glu missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304706 c.1776C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.39 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304766 c.1836C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304847 c.1917C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304853 c.1923C>T synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304889 c.1959G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304915 p.Asp662Gly missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304960 p.Arg677His missense_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304988 c.2058G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1305006 p.Glu692Asp missense_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1305013 p.Thr695Ser missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1305039 c.2109G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305063 c.2133G>A synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305084 c.2154C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305092 p.Ala721Gly missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305215 p.Ser762Thr missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305231 c.2301C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305240 c.2310T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305243 c.2313T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305252 c.2322G>A synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305282 c.2352T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305297 c.2367G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305300 c.2370A>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305303 c.2373T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305331 p.Glu801Asn missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305336 c.2406T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305393 c.2463T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305423 c.2493T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
Rv1258c 1407373 c.-33A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
pyrazinamide
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473733 n.76C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474953 n.1296C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475243 n.1586G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475245 n.1588T>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475247 n.1592_1594delTCA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475254 n.1597delCinsTGAT non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475265 n.1608G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475266 n.1609T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475273 n.1616T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475275 n.1618C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1673490 c.-712A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673523 c.-679G>T upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1673535 c.-667A>G upstream_gene_variant 0.29 isoniazid
ethionamide
inhA 1673547 c.-655T>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673568 c.-634C>A upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1673569 c.-633G>A upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1673574 c.-628C>G upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1673580 c.-622T>C upstream_gene_variant 0.28 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673610 c.-592C>T upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673679 c.-523T>C upstream_gene_variant 0.2 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673710 c.-492_-490delCTAinsATC upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673721 c.-481C>T upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673724 c.-478A>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673758 c.-444A>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673862 c.-340C>T upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673890 c.-312G>T upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673916 c.-286A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673925 c.-277C>T upstream_gene_variant 0.3 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673941 c.-261G>T upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1673946 c.-256C>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1673985 c.-217C>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1674015 c.-187C>T upstream_gene_variant 0.35 isoniazid Uncertain significance
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674037 c.-165C>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674042 c.-160G>C upstream_gene_variant 0.33 isoniazid Uncertain significance
ethionamide
inhA 1674049 c.-153_-151delCAAinsGAC upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674054 c.-148T>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674063 c.-139G>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674079 c.-123C>G upstream_gene_variant 0.29 isoniazid
ethionamide
inhA 1674098 c.-104T>C upstream_gene_variant 0.29 isoniazid
ethionamide
inhA 1674114 c.-88T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1674123 c.-79T>C upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1674126 c.-76G>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1674141 c.-61T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1674507 c.306G>A synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.31 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.3 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.34 isoniazid
ethionamide
inhA 1674601 p.Leu134Ala missense_variant 0.38 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674660 c.459G>T synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674732 c.531C>T synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.28 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674753 c.552G>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.28 isoniazid
ethionamide
rpsA 1833532 c.-10A>C upstream_gene_variant 0.18 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.37 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833799 c.258C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833909 p.Asp123Ala missense_variant 0.54 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833982 c.441C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.32 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGT synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.41 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.44 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.37 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.39 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834630 c.1089G>A synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.22 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.31 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.31 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.3 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.29 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.3 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.27 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.21 linezolid
tsnR 1853456 c.-150C>T upstream_gene_variant 0.19 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.19 linezolid
tsnR 1853513 c.-93C>T upstream_gene_variant 0.17 linezolid
tsnR 1853517 c.-89G>A upstream_gene_variant 0.18 linezolid
tsnR 1853525 c.-81G>T upstream_gene_variant 0.18 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102671 c.372T>G synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2102680 c.363T>G synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2102686 c.357G>C synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2102695 c.348C>T synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2102700 c.343C>T synonymous_variant 0.28 isoniazid
delamanid
ethionamide
ndh 2102710 c.333C>T synonymous_variant 0.28 isoniazid
delamanid
ethionamide
ndh 2102718 p.Gln109Glu missense_variant 0.26 isoniazid
delamanid
ethionamide
ndh 2102728 c.315T>C synonymous_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102736 c.307T>C synonymous_variant 0.28 isoniazid
delamanid
ethionamide
ndh 2102737 p.Glu102Asp missense_variant 0.28 isoniazid
delamanid
ethionamide
ndh 2102743 c.300C>G synonymous_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102750 p.Cys98Phe missense_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102754 p.Gln97Lys missense_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102755 c.288G>C synonymous_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102758 c.285C>T synonymous_variant 0.27 isoniazid
delamanid
ethionamide
ndh 2102779 c.264C>T synonymous_variant 0.23 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.23 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.21 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.21 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.23 isoniazid
kasA 2518612 c.498C>G synonymous_variant 0.23 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.27 isoniazid
kasA 2518656 p.Ala181Gly missense_variant 0.26 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.3 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.31 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.31 isoniazid
kasA 2518699 c.585C>T synonymous_variant 0.31 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.3 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.3 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.33 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.33 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.37 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.37 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.31 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.28 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.28 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.29 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.26 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.24 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.24 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.32 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.3 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.24 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.28 isoniazid
kasA 2518897 c.783G>A synonymous_variant 0.24 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.24 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.21 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.21 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.21 isoniazid
kasA 2519029 c.915C>T synonymous_variant 0.21 isoniazid
eis 2715744 c.-413delA upstream_gene_variant 1.0 kanamycin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.38 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.31 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.41 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.38 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.32 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783188 c.855G>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.44 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.32 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065421 c.771G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065451 c.741G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065457 c.735A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065460 c.732G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065463 c.729T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065511 c.681G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065517 c.675C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065520 c.672G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065532 c.660A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065535 c.657C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065553 c.639A>G synonymous_variant 0.25 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065562 c.630T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065568 p.Ile208Leu missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065576 p.Ala206Ser missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065580 c.612G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065586 c.606C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065589 c.603C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065595 p.Leu199Phe missense_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065607 c.585C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066321 c.-130C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066369 c.-180_-178delAGCinsGCG upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066390 c.-199C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066398 c.-207G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066399 c.-210_-208delATTinsTCC upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066435 c.-246_-244delGGTinsAAC upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066477 c.-286C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066507 c.-316C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066612 c.-421G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066726 c.-535C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066861 c.-670C>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067391 c.555G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067463 p.Ile161Val missense_variant 0.27 para-aminosalicylic_acid
thyX 3067472 c.474C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067487 c.459G>A synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.26 para-aminosalicylic_acid
thyX 3067522 p.Thr142Ala missense_variant 0.24 para-aminosalicylic_acid
thyX 3067711 p.Ser79Thr missense_variant 0.19 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.2 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.22 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067856 p.Asp30Glu missense_variant 0.23 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.22 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.25 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.25 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074196 c.276G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.18 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074361 c.111T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074372 p.Met34Leu missense_variant 0.21 para-aminosalicylic_acid
thyA 3074379 c.93C>T synonymous_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3623484 p.Phe476Tyr missense_variant 0.22 rifampicin
bedaquiline
lpqB 3623492 c.1419T>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3623512 p.Gly467Ser missense_variant 0.21 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.34 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624179 c.732C>T synonymous_variant 0.34 rifampicin
bedaquiline
lpqB 3624182 c.729C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624194 c.717C>G synonymous_variant 0.32 rifampicin
bedaquiline
lpqB 3624200 c.711A>G synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624204 p.Ser236Asn missense_variant 0.27 rifampicin
bedaquiline
lpqB 3624209 c.702A>C synonymous_variant 0.27 rifampicin
bedaquiline
lpqB 3624224 c.687T>C synonymous_variant 0.3 rifampicin
bedaquiline
lpqB 3624242 c.669A>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624245 c.666A>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624254 c.657T>A synonymous_variant 0.26 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625510 c.-600T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625513 c.-603G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625518 c.-608T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625525 c.-615G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625528 c.-618G>T upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.3 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.33 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.37 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.42 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625777 c.-867C>G upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.32 rifampicin Uncertain significance
bedaquiline Uncertain significance
lpqB 3625803 c.-893C>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626704 c.-91C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626750 c.-137T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626765 c.585C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3626891 c.-278G>A upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrA 3627056 c.294C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrB 3627125 c.-512C>G upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.51 rifampicin
bedaquiline
mtrA 3627175 c.175C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627196 c.-583C>T upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.23 rifampicin
bedaquiline
mtrB 3627360 c.-747G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
rpoA 3877587 p.Ser307Ala missense_variant 0.23 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.35 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.35 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.25 rifampicin
rpoA 3877803 c.705G>T synonymous_variant 0.25 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.26 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.24 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.24 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.24 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.24 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>C synonymous_variant 0.23 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.29 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>C synonymous_variant 0.31 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.29 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.29 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.28 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>A synonymous_variant 0.29 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.29 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.3 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.3 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.3 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.31 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.29 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.28 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.27 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.29 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.32 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.29 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.3 rifampicin
rpoA 3878226 c.282C>G synonymous_variant 0.24 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.27 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.34 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.36 rifampicin
rpoA 3878284 p.Glu75Ala missense_variant 0.42 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.38 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.32 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.33 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.35 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.35 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.36 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.36 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.37 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.37 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.37 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.35 rifampicin
rpoA 3878448 c.60G>A synonymous_variant 0.35 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.33 rifampicin
rpoA 3878459 p.Asn17Asp missense_variant 0.33 rifampicin
rpoA 3878465 p.Thr15Ser missense_variant 0.35 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.35 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.37 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.3 rifampicin
rpoA 3878759 c.-252T>C upstream_gene_variant 0.33 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.35 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.33 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.33 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.3 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.43 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.43 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.38 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGTG upstream_gene_variant 0.35 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.27 rifampicin
rpoA 3879007 c.-500G>C upstream_gene_variant 0.31 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879028 c.-521C>T upstream_gene_variant 0.42 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.39 rifampicin
rpoA 3879067 c.-560G>A upstream_gene_variant 0.36 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.4 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.36 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.36 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.35 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.36 rifampicin
rpoA 3879166 c.-659C>G upstream_gene_variant 0.32 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.35 pretomanid
delamanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.19 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.21 pretomanid
delamanid
ddn 3986672 c.-172G>A upstream_gene_variant 0.19 pretomanid
delamanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.19 pretomanid
delamanid
ddn 3987084 p.Gly81Ser missense_variant 1.0 pretomanid
delamanid Uncertain significance
clpC1 4038356 c.2349T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038398 c.2307G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.43 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.39 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.4 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.41 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.42 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.41 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.41 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.42 pyrazinamide
clpC1 4038536 c.2169C>A synonymous_variant 0.42 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.45 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.39 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.39 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.39 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.44 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.32 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039073 c.1632C>A synonymous_variant 0.39 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.41 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.36 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.36 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.43 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.42 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.25 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039925 c.779_780delGCinsTCGAGG frameshift_variant&synonymous_variant 0.36 pyrazinamide
clpC1 4039927 c.774_777delTAGC frameshift_variant 0.36 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.34 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.31 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.42 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.41 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.38 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.39 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.4 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.32 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.28 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040408 c.297C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.29 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.21 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040596 c.109C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.24 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.23 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.27 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.22 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040674 c.31A>C synonymous_variant 0.2 pyrazinamide
clpC1 4040675 c.30C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040678 c.27C>A synonymous_variant 0.2 pyrazinamide
panD 4043865 p.Gly139Arg missense_variant 0.2 pyrazinamide Uncertain significance
panD 4043872 p.Gly137Val missense_variant 0.2 pyrazinamide Uncertain significance
panD 4043876 p.Leu136Ile missense_variant 0.21 pyrazinamide
panD 4043883 c.399C>T synonymous_variant 0.2 pyrazinamide
panD 4043886 c.396A>C synonymous_variant 0.2 pyrazinamide
panD 4043896 p.Gly129Ala missense_variant 0.2 pyrazinamide
panD 4043916 c.366A>G synonymous_variant 0.19 pyrazinamide
panD 4043922 c.360T>C synonymous_variant 0.18 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.2 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.23 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.22 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.28 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.25 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.25 pyrazinamide
panD 4044871 c.-590C>T upstream_gene_variant 0.2 pyrazinamide
panD 4044892 c.-611G>A upstream_gene_variant 0.21 pyrazinamide
panD 4044895 c.-614A>T upstream_gene_variant 0.21 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.21 pyrazinamide
panD 4044902 c.-623_-621delACGinsGCC upstream_gene_variant 0.23 pyrazinamide
panD 4044908 c.-628_-627delCTinsTC upstream_gene_variant 0.22 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044927 c.-646C>A upstream_gene_variant 0.2 pyrazinamide
panD 4044936 c.-655A>T upstream_gene_variant 0.19 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.2 pyrazinamide
panD 4044959 c.-678C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.2 pyrazinamide
glpK 4138429 c.1327T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138433 c.1323C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138436 c.1320C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138442 c.1314C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138451 c.1305T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138472 c.1284G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138478 c.1278T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138481 p.Val425Ala missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4138489 c.1267T>C synonymous_variant 0.25 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138490 c.1266G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138495 p.Gln421Glu missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138496 c.1260G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138502 c.1254T>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138511 c.1245C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138518 p.Glu413Ala missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138523 c.1233C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138535 c.1221T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138565 c.1191G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138568 c.1188A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138580 c.1176C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138601 c.1155G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138610 c.1146C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240277 p.Leu139Val missense_variant 0.22 ethambutol
embC 4240284 p.Thr141Ser missense_variant 0.22 ethambutol
embC 4240297 c.435T>C synonymous_variant 0.19 ethambutol
embC 4240307 p.Gly149Ser missense_variant 0.28 ethambutol Uncertain significance
embC 4240313 p.Thr151Ala missense_variant 0.22 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.25 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.41 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.44 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.56 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.39 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.45 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.45 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.45 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.44 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.44 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.52 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.49 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.51 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.49 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.46 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.46 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.49 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.43 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.43 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.42 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.36 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.33 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.33 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240969 c.1107C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240971 p.Ala370Val missense_variant 0.33 ethambutol
embC 4240979 p.Thr373Gln missense_variant 0.34 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.33 ethambutol
embC 4240987 c.1125G>C synonymous_variant 0.33 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.33 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.37 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.35 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.38 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.38 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.39 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.42 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.39 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.38 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.34 ethambutol
embC 4241081 c.1219C>T synonymous_variant 0.31 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.28 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.28 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.23 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.23 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.24 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.24 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.27 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.26 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.96 ethambutol Not assoc w R
embC 4242762 p.Arg967Gln missense_variant 0.21 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.19 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.2 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.22 ethambutol
embC 4242791 p.Ala977Ser missense_variant 0.2 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.2 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.22 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.23 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.25 ethambutol
embA 4242844 c.-389A>G upstream_gene_variant 0.24 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.24 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.23 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.22 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.22 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4242892 c.-341G>C upstream_gene_variant 0.24 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 0.28 ethambutol
embA 4242919 c.-314A>G upstream_gene_variant 0.3 ethambutol
embC 4242928 c.3066A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embA 4242931 c.-302G>C upstream_gene_variant 0.31 ethambutol
embA 4242940 c.-293T>C upstream_gene_variant 0.31 ethambutol
embC 4242941 p.His1027Asn missense_variant 0.27 ethambutol
embA 4242946 c.-287T>C upstream_gene_variant 0.29 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245315 p.Val695Thr missense_variant 0.19 ethambutol
embA 4245340 p.Gly703Ala missense_variant 0.2 ethambutol
embA 4245355 p.Ala708Gly missense_variant 0.18 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247455 c.942C>T synonymous_variant 0.2 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.26 ethambutol
embB 4247476 c.963C>G synonymous_variant 0.26 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.29 ethambutol
embB 4247519 c.1006C>T synonymous_variant 0.41 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.36 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.36 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.31 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.24 ethambutol
embB 4247776 c.1263G>C synonymous_variant 0.28 ethambutol
embB 4247795 c.1282_1284delCTCinsTTG synonymous_variant 0.33 ethambutol
embB 4247800 c.1287A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247812 c.1299G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247815 c.1302C>G synonymous_variant 0.32 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.31 ethambutol Uncertain significance
embB 4247827 c.1314C>G synonymous_variant 0.32 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.29 ethambutol
embB 4247857 c.1344C>G synonymous_variant 0.33 ethambutol
embB 4247858 c.1345C>T synonymous_variant 0.34 ethambutol
embB 4247869 c.1356G>C synonymous_variant 0.38 ethambutol
embB 4247879 p.Val456Ile missense_variant 0.39 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.43 ethambutol
embB 4247905 c.1392G>A synonymous_variant 0.44 ethambutol
embB 4247908 c.1395C>T synonymous_variant 0.41 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embB 4247923 c.1410T>C synonymous_variant 0.45 ethambutol
embB 4247938 c.1425G>C synonymous_variant 0.4 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.39 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.39 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.4 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.39 ethambutol
embB 4247992 c.1479G>C synonymous_variant 0.41 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.39 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.35 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.35 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.3 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.3 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.3 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.32 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.28 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.38 ethambutol
embB 4248101 c.1588C>T synonymous_variant 0.38 ethambutol
embB 4248106 c.1593C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>C synonymous_variant 0.35 ethambutol
embB 4248146 p.Ile545Val missense_variant 0.34 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>G synonymous_variant 0.36 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.37 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.37 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.37 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.36 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.37 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.41 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.43 ethambutol
embB 4248295 c.1782C>T synonymous_variant 0.43 ethambutol
embB 4248307 c.1794G>C synonymous_variant 0.43 ethambutol
embB 4248313 c.1800C>T synonymous_variant 0.43 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.41 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.41 ethambutol
embB 4248340 c.1827G>C synonymous_variant 0.39 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.34 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.36 ethambutol
embB 4248358 c.1845_1850delCCCATCinsGCAT frameshift_variant&missense_variant 0.35 ethambutol
embB 4248397 c.1884C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248407 c.1894_1896delTTAinsCTG synonymous_variant 0.27 ethambutol
embB 4248416 p.Leu635Val missense_variant 0.24 ethambutol
embB 4248424 c.1911G>C synonymous_variant 0.23 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.23 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.22 ethambutol
embB 4249424 c.2911C>T synonymous_variant 0.21 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.22 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.26 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.26 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.32 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.38 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.38 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.38 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.37 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.37 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.35 ethambutol
embB 4249568 p.Ser1019Asn missense_variant 0.26 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.23 ethambutol
embB 4249581 p.Leu1023Gln missense_variant 0.25 ethambutol
embB 4249588 c.3075C>G synonymous_variant 0.23 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.22 ethambutol
embB 4249598 p.Glu1029Gln missense_variant 0.22 ethambutol
embB 4249607 p.Thr1032Val missense_variant 0.23 ethambutol
embB 4249615 c.3102C>T synonymous_variant 0.24 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.23 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269148 p.Val229Ala missense_variant 0.94 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R