TB-Profiler result

Run: SRR21700896
Summary

Run ID: SRR21700896

Sample name:

Date: 12-03-2024 19:05:04

Number of reads: 7710795

Percentage reads mapped: 99.98

Strain: lineage4.9

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones R gyrB p.Asp461Asn (1.00), gyrB p.Ala504Thr (1.00), gyrA p.Ala90Val (1.00)
Moxifloxacin R gyrB p.Asp461Asn (1.00), gyrB p.Ala504Thr (1.00), gyrA p.Ala90Val (1.00)
Ofloxacin R gyrB p.Asp461Asn (1.00), gyrB p.Ala504Thr (1.00), gyrA p.Ala90Val (1.00)
Levofloxacin R gyrB p.Asp461Asn (1.00), gyrB p.Ala504Thr (1.00), gyrA p.Ala90Val (1.00)
Ciprofloxacin R gyrB p.Asp461Asn (1.00), gyrB p.Ala504Thr (1.00), gyrA p.Ala90Val (1.00)
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrB 6620 p.Asp461Asn missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
gyrB 6749 p.Ala504Thr missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
gyrA 7570 p.Ala90Val missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
Rv1258c 1406686 p.Val219Ile missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpoA 3878614 c.-107A>C upstream_gene_variant 0.13
rpoA 3878619 c.-112A>C upstream_gene_variant 0.19