TB-Profiler result

Run: SRR5485522
Summary

Run ID: SRR5485522

Sample name:

Date: 18-08-2022 08:32:53

Number of reads: 112071

Percentage reads mapped: 98.72

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761097 p.Ser431Gly missense_variant 0.17 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 1.0 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.38 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.2 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7636 c.337delC frameshift_variant 0.2
rpoB 761143 p.Lys446Met missense_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.38
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.42
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.42
rrs 1473270 n.1425G>A non_coding_transcript_exon_variant 0.32
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.42
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.4
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.4
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.24
fabG1 1673396 c.-44A>G upstream_gene_variant 0.15
fabG1 1673400 c.-40C>T upstream_gene_variant 0.15
pncA 2288937 p.Ala102Glu missense_variant 0.14
pncA 2289319 c.-78C>G upstream_gene_variant 0.15