TB-Profiler result

Run: SRR6045261
Summary

Run ID: SRR6045261

Sample name:

Date: 04-04-2023 11:55:51

Number of reads: 1979325

Percentage reads mapped: 91.38

Strain: lineage1.1.2

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 1.0
lineage1.1 Indo-Oceanic EAI3;EAI4;EAI5;EAI6 RD239 1.0
lineage1.1.2 Indo-Oceanic EAI3;EAI5 RD239 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.16 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.46 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.13 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 1.0
gyrB 6124 c.885C>T synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8366 c.1065G>C synonymous_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9047 c.1746C>T synonymous_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9443 c.2142G>A synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576000 p.Asp218Ala missense_variant 1.0
rpoB 760490 c.684C>T synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
rpoC 765171 p.Pro601Leu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775979 c.2502G>A synonymous_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776395 p.Phe696Leu missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.22
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.22
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.22
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.23
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.19
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.24
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.45
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.45
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.45
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.45
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.15
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.47
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.15
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.45
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.29
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.19
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.62
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.25
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.42
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.42
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.24
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.52
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.71
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.59
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.17
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.55
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.35
rrs 1472689 n.844C>T non_coding_transcript_exon_variant 0.35
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.43
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.17
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.43
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.43
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.17
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.45
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.42
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.42
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.33
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.38
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.38
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.36
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.25
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.27
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.29
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.29
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.29
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.29
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.29
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.21
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.31
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.21
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.2
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.13
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.13
rrs 1473270 n.1425G>A non_coding_transcript_exon_variant 0.14
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.14
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.14
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.14
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.29
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.29
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.29
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.29
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.29
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.25
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.29
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.43
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.43
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.38
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.29
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.25
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.25
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.25
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.25
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.2
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 0.2
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.2
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.2
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.2
rrl 1475488 n.1831G>A non_coding_transcript_exon_variant 0.29
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.25
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.25
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.29
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.29
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.25
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.33
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.33
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.29
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.11
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.17
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.19
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.3
rrl 1476195 n.2538C>A non_coding_transcript_exon_variant 0.3
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.38
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.38
rrl 1476204 n.2547C>A non_coding_transcript_exon_variant 0.33
rrl 1476211 n.2554G>T non_coding_transcript_exon_variant 0.38
rrl 1476212 n.2555T>C non_coding_transcript_exon_variant 0.38
rrl 1476214 n.2557G>C non_coding_transcript_exon_variant 0.38
rrl 1476215 n.2558C>A non_coding_transcript_exon_variant 0.38
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.54
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.58
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.62
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.68
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.68
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.7
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.7
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.67
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.59
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.59
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.59
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.59
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.57
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.42
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.52
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.5
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.5
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.5
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.5
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.58
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.7
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.69
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.65
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.67
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.62
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.6
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.64
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.63
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.63
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.65
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.27
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.18
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167983 p.Gly877Asp missense_variant 1.0
PPE35 2169369 p.Gly415Ala missense_variant 0.98
PPE35 2170066 p.Ala183Thr missense_variant 0.14
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0
Rv2752c 3064632 c.1560C>T synonymous_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
fprA 3475129 p.Ala375Thr missense_variant 0.98
fprA 3475159 p.Asn385Asp missense_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243197 c.-36C>T upstream_gene_variant 1.0
embA 4243848 p.Val206Met missense_variant 1.0
embA 4245969 p.Pro913Ser missense_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0