Run ID: b4e1d151-d694-4a98-b5fb-435e861cbd0e
Sample name:
Date: 08-05-2024 15:17:31
Number of reads: 5545807
Percentage reads mapped: 98.11
Median coverage: 127
Strain: lineage6.3.1
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage6 | West-Africa 2 | RD702 | 1.0 |
| lineage6.3 | West-Africa 2 | RD702 | 1.0 |
| lineage6.3.1 | West-Africa 2 | RD702 | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| moxifloxacin | ||||
| levofloxacin | ||||
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | ||||
| amikacin | ||||
| kanamycin | ||||
| capreomycin | ||||
| clofazimine | ||||
| ethionamide | ||||
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 6446 | p.Ala403Ser | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| fgd1 | 490751 | c.-32T>G | upstream_gene_variant | 0.17 | delamanid | |
| fgd1 | 491668 | p.Lys296Glu | missense_variant | 1.0 | delamanid | Uncertain significance |
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | delamanid | |
| mshA | 576710 | p.Arg455Gly | missense_variant | 0.13 | ethionamide | |
| isoniazid | ||||||
| rpoB | 759620 | c.-187A>C | upstream_gene_variant | 0.13 | rifampicin | |
| rpoB | 760391 | c.585C>T | synonymous_variant | 0.69 | rifampicin | |
| rpoB | 760969 | p.Ser388Leu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 761723 | p.Glu639Asp | missense_variant | 0.98 | rifampicin | Uncertain significance |
| rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763471 | c.102C>T | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 0.99 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 777427 | p.Thr352Pro | missense_variant | 0.15 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | delamanid | Uncertain significance |
| fbiC | 1303016 | p.Val29Gly | missense_variant | 0.13 | delamanid | |
| fbiC | 1304166 | c.1236A>G | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1305048 | c.2118G>A | synonymous_variant | 1.0 | delamanid | |
| atpE | 1461251 | c.207G>T | synonymous_variant | 1.0 | bedaquiline | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1475029 | n.1372T>G | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| inhA | 1674434 | p.Val78Ala | missense_variant | 0.99 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| ndh | 2102694 | p.Val117Ile | missense_variant | 0.99 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 0.99 | isoniazid | Uncertain significance |
| katG | 2155503 | c.609C>T | synonymous_variant | 1.0 | isoniazid | |
| PPE35 | 2167859 | c.2754T>G | synonymous_variant | 0.15 | pyrazinamide | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169320 | p.Leu431Phe | missense_variant | 0.15 | pyrazinamide | |
| PPE35 | 2169866 | c.747G>C | synonymous_variant | 0.13 | pyrazinamide | |
| PPE35 | 2170045 | p.Thr190Pro | missense_variant | 0.12 | pyrazinamide | |
| PPE35 | 2170390 | p.Trp75Gly | missense_variant | 0.12 | pyrazinamide | |
| PPE35 | 2170436 | c.177T>G | synonymous_variant | 0.11 | pyrazinamide | |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2222852 | p.Ala105Thr | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714561 | p.Gly258Cys | missense_variant | 0.12 | kanamycin | |
| amikacin | ||||||
| ahpC | 2726338 | p.Val49Gly | missense_variant | 0.25 | isoniazid | |
| ahpC | 2726341 | p.Val50Gly | missense_variant | 0.17 | isoniazid | |
| pepQ | 2859904 | p.Val172Gly | missense_variant | 0.12 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2987323 | p.Val162Gly | missense_variant | 0.15 | para-aminosalicylic_acid | |
| Rv2752c | 3064745 | p.Thr483Pro | missense_variant | 0.13 | rifampicin | |
| isoniazid | ||||||
| ald | 3086728 | c.-92C>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | |
| fbiD | 3339273 | c.156T>G | synonymous_variant | 0.13 | delamanid | |
| fbiD | 3339688 | p.Thr191Pro | missense_variant | 0.15 | delamanid | |
| fbiD | 3339749 | p.Val211Gly | missense_variant | 0.12 | delamanid | |
| Rv3083 | 3449781 | c.1278G>A | synonymous_variant | 1.0 | ethionamide | |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| fprA | 3475159 | p.Asn385Asp | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| fbiB | 3642751 | p.Asp406Ala | missense_variant | 0.17 | delamanid | |
| fbiB | 3642772 | p.Asp413Ala | missense_variant | 0.17 | delamanid | |
| rpoA | 3877696 | p.Thr271Ile | missense_variant | 0.99 | rifampicin | Uncertain significance |
| rpoA | 3878653 | c.-146A>C | upstream_gene_variant | 0.12 | rifampicin | |
| clpC1 | 4038857 | c.1848C>A | synonymous_variant | 0.12 | pyrazinamide | |
| embC | 4239834 | c.-29G>C | upstream_gene_variant | 0.12 | ethambutol | |
| embC | 4239838 | c.-25T>C | upstream_gene_variant | 0.13 | ethambutol | |
| embC | 4239842 | c.-21C>A | upstream_gene_variant | 0.13 | ethambutol | |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4241843 | p.Leu661Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4242393 | p.Asp844Ala | missense_variant | 0.12 | ethambutol | |
| embA | 4242406 | c.-827A>C | upstream_gene_variant | 0.14 | ethambutol | |
| embC | 4242414 | p.Leu851Arg | missense_variant | 0.12 | ethambutol | |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4242822 | p.Val987Gly | missense_variant | 0.12 | ethambutol | |
| embA | 4244220 | c.988C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244379 | p.Pro383Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4246864 | c.351C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247076 | p.Val188Gly | missense_variant | 0.12 | ethambutol | |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4268477 | c.360C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| aftB | 4269351 | c.-515C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4269504 | c.-668A>G | upstream_gene_variant | 0.15 | capreomycin | |
| amikacin | ||||||
| ubiA | 4269511 | p.Val108Gly | missense_variant | 0.13 | ethambutol | |
| ubiA | 4269514 | p.Val107Gly | missense_variant | 0.14 | ethambutol | |
| aftB | 4269522 | c.-686C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| aftB | 4269606 | c.-770T>C | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| aftB | 4269687 | c.-851C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ethA | 4326044 | p.Gly477Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethA | 4326465 | p.Ile337Val | missense_variant | 0.99 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407715 | p.Lys163Arg | missense_variant | 1.0 | streptomycin |
