Run ID: c39e13c5-d1b0-42c2-8dc4-a1cadc99cacb
Sample name:
Date: 25-05-2023 16:33:53
Number of reads: 1138888
Percentage reads mapped: 98.58
Median coverage: 30
Strain: lineage6.3.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage6 | West-Africa 2 | RD702 | 1.0 |
lineage6.3 | West-Africa 2 | RD702 | 1.0 |
lineage6.3.1 | West-Africa 2 | RD702 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
moxifloxacin | ||||
levofloxacin | ||||
bedaquiline | ||||
delamanid | ||||
pretomanid | ||||
linezolid | ||||
streptomycin | ||||
amikacin | ||||
kanamycin | ||||
capreomycin | ||||
clofazimine | ||||
ethionamide | ||||
para-aminosalicylic_acid | ||||
cycloserine |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6446 | p.Ala403Ser | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
fgd1 | 491668 | p.Lys296Glu | missense_variant | 1.0 | delamanid | Uncertain significance |
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | delamanid | |
mshA | 576108 | p.Ala254Gly | missense_variant | 0.27 | ethionamide | Uncertain significance |
isoniazid | ||||||
mshA | 576636 | p.Trp430Leu | missense_variant | 0.14 | ethionamide | Uncertain significance |
isoniazid | ||||||
rpoB | 760969 | p.Ser388Leu | missense_variant | 0.93 | rifampicin | Uncertain significance |
rpoB | 761723 | p.Glu639Asp | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoB | 761955 | p.Ile717Val | missense_variant | 0.14 | rifampicin | |
rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | delamanid | Uncertain significance |
Rv1258c | 1406363 | c.978A>G | synonymous_variant | 1.0 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
atpE | 1461251 | c.207G>T | synonymous_variant | 1.0 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
inhA | 1674434 | p.Val78Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
ndh | 2101987 | c.1056C>T | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
ndh | 2102022 | p.Lys341Glu | missense_variant | 1.0 | ethionamide | |
isoniazid | Uncertain significance | |||||
ndh | 2102023 | c.1020G>T | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
ndh | 2102694 | p.Val117Ile | missense_variant | 0.97 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
katG | 2155503 | c.609C>T | synonymous_variant | 1.0 | isoniazid | |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
Rv1979c | 2222852 | p.Ala105Thr | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
pepQ | 2860159 | p.Ala87Gly | missense_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
ald | 3086728 | c.-92C>T | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086958 | p.Asp47Tyr | missense_variant | 1.0 | cycloserine | |
ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | |
fbiD | 3339341 | c.227delG | frameshift_variant | 0.11 | delamanid | |
fbiD | 3339734 | p.Ala206Gly | missense_variant | 0.45 | delamanid | |
Rv3083 | 3449781 | c.1278G>A | synonymous_variant | 1.0 | ethionamide | |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
fprA | 3474911 | p.Val302Gly | missense_variant | 1.0 | capreomycin | |
amikacin | ||||||
fprA | 3475159 | p.Asn385Asp | missense_variant | 1.0 | capreomycin | Uncertain significance |
amikacin | Uncertain significance | |||||
whiB7 | 3568428 | c.252A>G | synonymous_variant | 0.29 | streptomycin | |
kanamycin | ||||||
amikacin | ||||||
Rv3236c | 3612159 | p.Arg320Trp | missense_variant | 0.12 | pyrazinamide | |
rpoA | 3877696 | p.Thr271Ile | missense_variant | 1.0 | rifampicin | Uncertain significance |
clpC1 | 4040489 | c.216G>A | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4040716 | c.-12A>T | upstream_gene_variant | 0.17 | pyrazinamide | |
embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
embC | 4241843 | p.Leu661Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
embA | 4244220 | c.988C>T | synonymous_variant | 1.0 | ethambutol | |
embA | 4244379 | p.Pro383Ser | missense_variant | 0.97 | ethambutol | Uncertain significance |
embB | 4246864 | c.351C>T | synonymous_variant | 1.0 | ethambutol | |
embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
aftB | 4267751 | p.Asp362Glu | missense_variant | 0.12 | capreomycin | |
amikacin | ||||||
aftB | 4268477 | c.360C>T | synonymous_variant | 1.0 | capreomycin | |
amikacin | ||||||
aftB | 4269351 | c.-515C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Uncertain significance |
aftB | 4269522 | c.-686C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
aftB | 4269606 | c.-770T>C | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
ethA | 4326465 | p.Ile337Val | missense_variant | 1.0 | ethionamide | Uncertain significance |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin |