TB-Profiler result

Run: ERR046844
Summary

Run ID: ERR046844

Sample name:

Date: 31-03-2023 08:53:37

Number of reads: 5244511

Percentage reads mapped: 99.18

Strain: lineage1.2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 0.98
lineage1.2.2 Indo-Oceanic EAI1 RD239 0.99
lineage1.2.2.1 Indo-Oceanic NA RD239 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
embB 4247368 p.Phe285Leu missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5075 c.-165C>T upstream_gene_variant 0.99
gyrB 6112 p.Met291Ile missense_variant 0.99
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491027 p.Asn82Thr missense_variant 0.22
fgd1 491742 c.960T>C synonymous_variant 0.98
rpoB 759620 c.-187A>C upstream_gene_variant 0.34
rpoC 762836 c.-534C>G upstream_gene_variant 0.38
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 0.97
rpoC 763886 c.517C>A synonymous_variant 0.97
rpoC 764725 p.Phe452Leu missense_variant 0.31
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.99
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302976 p.Val16Phe missense_variant 0.99
Rv1258c 1406750 c.591C>A synonymous_variant 0.17
embR 1417019 p.Cys110Tyr missense_variant 0.99
atpE 1461019 c.-26C>A upstream_gene_variant 0.24
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.22
inhA 1674892 p.Asn231Asp missense_variant 0.26
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.99
PPE35 2167926 p.Leu896Ser missense_variant 0.99
PPE35 2169866 c.747G>C synonymous_variant 0.41
PPE35 2170156 p.Ala153Pro missense_variant 0.19
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 0.99
kasA 2519353 p.Phe413Leu missense_variant 0.97
eis 2714366 p.Val323Leu missense_variant 0.3
eis 2715586 c.-254G>C upstream_gene_variant 0.2
ahpC 2726051 c.-142G>A upstream_gene_variant 0.99
ahpC 2726550 p.Gln120Lys missense_variant 0.2
ahpC 2726756 c.564C>G synonymous_variant 0.25
pepQ 2859381 c.1038C>G synonymous_variant 0.17
Rv2752c 3064552 p.Arg547Pro missense_variant 0.18
thyX 3067995 c.-50A>C upstream_gene_variant 0.19
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339273 c.156T>G synonymous_variant 0.34
fbiD 3339550 p.Gly145Trp missense_variant 0.18
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 0.99
fprA 3475159 p.Asn385Asp missense_variant 1.0
Rv3236c 3612137 p.Gly327Ala missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.33
fbiB 3642734 c.1200G>C synonymous_variant 0.18
rpoA 3878238 p.Asp90Glu missense_variant 0.17
ddn 3987013 p.Gly57Ala missense_variant 0.18
clpC1 4039932 p.Gly258Val missense_variant 0.27
clpC1 4040517 p.Val63Ala missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4240750 c.888C>T synonymous_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 0.97
embC 4241456 p.Ala532Pro missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.28
embA 4245969 p.Pro913Ser missense_variant 0.99
embB 4247646 p.Glu378Ala missense_variant 0.98
embB 4248725 p.Ser738Ala missense_variant 0.22
embB 4249019 p.Gly836Arg missense_variant 0.99
ubiA 4269387 p.Glu149Asp missense_variant 0.99
ubiA 4269529 p.Ala102Gly missense_variant 0.16
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethA 4326439 p.Asn345Lys missense_variant 0.99
ethA 4327672 c.-199G>A upstream_gene_variant 0.21
ethR 4327912 p.Arg122Gly missense_variant 0.27
ethR 4328030 p.Ala161Val missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.97
gid 4407873 c.330G>T synonymous_variant 0.99
gid 4408179 c.24G>T synonymous_variant 0.98