TB-Profiler result

Run: ERR1633836
Summary

Run ID: ERR1633836

Sample name:

Date: 18-08-2022 14:48:58

Number of reads: 3134699

Percentage reads mapped: 99.54

Strain: lineage4.3.2.1;lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.75
lineage4 Euro-American LAM;T;S;X;H None 0.23
lineage4.3 Euro-American (LAM) mainly-LAM None 0.2
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.77
lineage4.3.2 Euro-American (LAM) LAM3 None 0.23
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.81
lineage4.3.2.1 Euro-American (LAM) LAM3 RD761 0.23
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gid 4407967 p.Leu79Ser missense_variant 0.23 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5520 p.Pro94Leu missense_variant 0.21
gyrA 7222 c.-80C>T upstream_gene_variant 0.23
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491328 c.546C>G synonymous_variant 0.87
fgd1 491330 p.Lys183Met missense_variant 0.88
fgd1 491742 c.960T>C synonymous_variant 0.74
mshA 575907 p.Ala187Val missense_variant 0.94
rpoC 763031 c.-339T>C upstream_gene_variant 0.88
rpoC 764995 c.1626C>G synonymous_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.26
inhA 1674952 p.Pro251Ala missense_variant 0.17
rpsA 1834177 c.636A>C synonymous_variant 0.84
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.84
ribD 2987307 p.Ala157Pro missense_variant 0.21
thyA 3073806 c.666C>G synonymous_variant 0.27
thyA 3073868 p.Thr202Ala missense_variant 0.16
ald 3086788 c.-32T>C upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.79
gid 4407588 c.615A>G synonymous_variant 0.76
gid 4407927 p.Glu92Asp missense_variant 0.76
gid 4408156 p.Leu16Arg missense_variant 0.25