Run ID: ERR2513547
Sample name:
Date: 20-10-2023 10:55:20
Number of reads: 3414698
Percentage reads mapped: 99.21
Strain: lineage3.1.2.1
Drug-resistance: Other
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | ||
Isoniazid | ||
Ethambutol | ||
Pyrazinamide | ||
Streptomycin | R | rrs n.888G>A (0.28) |
Fluoroquinolones | R | gyrB p.Asn499Thr (1.00), gyrA p.Asp94Gly (1.00) |
Moxifloxacin | R | gyrB p.Asn499Thr (1.00), gyrA p.Asp94Gly (1.00) |
Ofloxacin | R | gyrB p.Asn499Thr (1.00), gyrA p.Asp94Gly (1.00) |
Levofloxacin | R | gyrB p.Asn499Thr (1.00), gyrA p.Asp94Gly (1.00) |
Ciprofloxacin | R | gyrB p.Asn499Thr (1.00), gyrA p.Asp94Gly (1.00) |
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage3 | East-African-Indian | CAS | RD750 | 1.0 |
lineage3.1 | East-African-Indian | Non-CAS1-Delhi | RD750 | 1.0 |
lineage3.1.2 | East-African-Indian | CAS;CAS2 | RD750 | 1.0 |
lineage3.1.2.1 | East-African-Indian | CAS2 | RD750 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrB | 6735 | p.Asn499Thr | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
gyrA | 7582 | p.Asp94Gly | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rrs | 1472733 | n.888G>A | non_coding_transcript_exon_variant | 0.28 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.99 |
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 |
rpoB | 759746 | c.-61C>T | upstream_gene_variant | 1.0 |
rpoC | 762434 | c.-936T>G | upstream_gene_variant | 1.0 |
rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1472544 | n.699C>A | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472545 | n.700A>T | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472566 | n.721G>A | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472571 | n.726G>C | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472579 | n.734G>T | non_coding_transcript_exon_variant | 0.25 |
rrs | 1472581 | n.736A>T | non_coding_transcript_exon_variant | 0.3 |
rrs | 1472742 | n.897C>T | non_coding_transcript_exon_variant | 0.24 |
rrs | 1472744 | n.899A>G | non_coding_transcript_exon_variant | 0.24 |
rrs | 1472781 | n.936C>T | non_coding_transcript_exon_variant | 0.25 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 |
PPE35 | 2168604 | p.Pro670Leu | missense_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
pncA | 2289047 | c.195C>T | synonymous_variant | 1.0 |
pncA | 2289365 | c.-125delC | upstream_gene_variant | 1.0 |
ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 1.0 |
Rv2752c | 3065593 | p.Leu200Arg | missense_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
embC | 4242075 | p.Arg738Gln | missense_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embA | 4245122 | c.1890C>T | synonymous_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 |