TB-Profiler result

Run: ERR270697

Summary

Run ID: ERR270697

Sample name:

Date: 31-03-2023 23:11:56

Number of reads: 5595707

Percentage reads mapped: 99.6

Strain: lineage2.1

Drug-resistance: HR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.1 East-Asian (non-Beijing) None None 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 0.99 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.96
rpoC 763031 c.-339T>C upstream_gene_variant 0.99
rpoC 765121 c.1752G>A synonymous_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304159 p.Val410Gly missense_variant 0.3
fbiC 1304443 p.Ala505Thr missense_variant 1.0
fbiC 1305188 p.Leu753Arg missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475145 n.1488C>T non_coding_transcript_exon_variant 0.91
rpsA 1834177 c.636A>C synonymous_variant 0.94
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103038 p.Ser2Asn missense_variant 0.98
katG 2154724 p.Arg463Leu missense_variant 0.98
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167998 p.Pro872Leu missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99
eis 2715282 c.51C>T synonymous_variant 1.0
pepQ 2859873 p.Asp182Glu missense_variant 0.96
Rv2752c 3065616 c.576C>T synonymous_variant 0.99
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
clpC1 4040841 c.-138delG upstream_gene_variant 0.96
embC 4242425 p.Arg855Gly missense_variant 0.21
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246088 c.-426A>G upstream_gene_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.97