TB-Profiler result

Run: ERR3275709
Summary

Run ID: ERR3275709

Sample name:

Date: 2024-04-14T04:43:45.633234

Number of reads: 5978981

Percentage reads mapped: 99.76

Median coverage: 76.0

Strain: lineage3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin gid c.115delC Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
gid 4408087 c.115delC frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8858 c.1557T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8909 c.1608C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8913 p.Lys538Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9596 c.2295G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13277 c.282T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734354 p.Pro34Leu missense_variant 1.0 rifampicin Not assoc w R
nusG 734472 c.219T>C synonymous_variant 0.11 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.12 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.12 rifampicin
nusG 734753 p.Thr167Met missense_variant 1.0 rifampicin Not assoc w R
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.15 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.15 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.15 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.14 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.12 rifampicin Uncertain significance
rpoB 760445 c.639C>T synonymous_variant 0.11 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.13 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.14 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.13 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.13 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.11 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.17 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.24 rifampicin Uncertain significance
rpoB 762137 c.2331C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.25 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762173 c.2367G>A synonymous_variant 0.26 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.19 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.14 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762863 c.3057T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.15 rifampicin
rpoC 762896 c.-474G>C upstream_gene_variant 0.14 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>A upstream_gene_variant 0.13 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.19 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.22 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.23 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.19 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.16 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.2 rifampicin
rpoC 763600 c.231C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>G synonymous_variant 0.12 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.1 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764181 p.Asp271Gly missense_variant 0.93 rifampicin Not assoc w R
rpoC 764278 c.909A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.12 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.18 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.19 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.19 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.2 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>T synonymous_variant 0.19 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.18 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 p.His465Gln missense_variant 0.15 rifampicin
rpoC 764767 c.1398G>C synonymous_variant 0.14 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.15 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>G synonymous_variant 0.13 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.12 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.12 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.13 rifampicin
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.13 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.22 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.25 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.26 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>T synonymous_variant 0.17 rifampicin
rpoC 765079 c.1710T>C synonymous_variant 0.17 rifampicin
rpoC 765082 c.1713G>T synonymous_variant 0.16 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.16 rifampicin
rpoC 765094 c.1725C>G synonymous_variant 0.16 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.14 rifampicin
rpoC 765892 c.2523T>A synonymous_variant 0.13 rifampicin
rpoC 765908 p.Leu847Ala missense_variant 0.15 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.16 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.12 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.12 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766435 p.Glu1022Asp missense_variant 0.13 rifampicin Uncertain significance
rpoC 767002 c.3633G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767012 c.3643C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.27 rifampicin
rpoC 767068 c.3699G>C synonymous_variant 0.29 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767087 c.3718_3720delTGCinsAT frameshift_variant&missense_variant 0.26 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.24 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.24 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 0.98 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471928 n.83T>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471930 n.85_89delGGAGAinsTTGCAGGG non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472067 n.222G>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_461delGTCCGGGTT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472309 n.464C>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469_470delATinsG non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473812 n.155G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_172insCT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474626 n.969T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474723 n.1066G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1475059 n.1404_1405delCA non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475064 n.1407G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475067 n.1410_1411insG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475081 n.1424C>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid Uncertain significance
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>C synonymous_variant 0.14 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.14 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.15 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833623 p.Lys28Ser missense_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTA frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833763 c.222C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.2 pyrazinamide
rpsA 1833799 c.258C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833805 c.264C>A synonymous_variant 0.18 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.12 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.12 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.11 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.16 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.16 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.12 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.12 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.12 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.22 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.13 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.12 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.12 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170769 c.-157C>T upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877734 c.774G>C synonymous_variant 0.12 rifampicin
clpC1 4038782 c.1923G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.19 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.14 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.12 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039088 c.1617G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.15 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.21 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.12 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.15 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039996 p.Glu237Lys missense_variant 0.19 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.2 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R