TB-Profiler result

Run: ERR3445487
Summary

Run ID: ERR3445487

Sample name:

Date: 2024-04-16T02:19:00.940300

Number of reads: 1199657

Percentage reads mapped: 40.8

Median coverage: 37.0

Strain: La1.7.X-unk4

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.7 M.bovis None 1.0
La1.7.X-unk4 M.bovis None 1.0
La1 M.bovis None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.29 rifampicin
rpoB 761565 p.Met587Leu missense_variant 0.29 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.36 rifampicin
rpoB 761603 c.1797C>G synonymous_variant 0.32 rifampicin
rpoB 761613 c.1807_1809delGCAinsTC frameshift_variant&missense_variant 0.28 rifampicin
rpoB 761631 p.Ala609Ser missense_variant 0.28 rifampicin
rpoB 761643 p.Val613Ile missense_variant 0.27 rifampicin Uncertain significance
rpoB 761648 c.1842T>C synonymous_variant 0.34 rifampicin
rpoB 761650 p.Ser615Asn missense_variant 0.27 rifampicin
rpoB 761654 p.Glu616Asp missense_variant 0.28 rifampicin
rpoB 761663 c.1857G>C synonymous_variant 0.24 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.31 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.19 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.21 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.18 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.17 rifampicin
rpoB 761967 p.Glu721Gln missense_variant 0.16 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.16 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.16 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.14 rifampicin
rpoB 762009 c.2203_2205delCTGinsGC frameshift_variant&missense_variant 0.13 rifampicin
rpoB 762015 p.Glu737Gln missense_variant 0.13 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.14 rifampicin
rpoB 762024 p.Val740Leu missense_variant 0.16 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762084 c.2278_2280delGCGinsCC frameshift_variant&missense_variant 0.23 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 762117 c.2311_2312delTCinsAG synonymous_variant 0.21 rifampicin
rpoB 762126 p.Val774Met missense_variant 0.3 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.3 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAT frameshift_variant&missense_variant 0.27 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Ser missense_variant 0.24 rifampicin
rpoB 762180 p.Asp792Asn missense_variant 0.23 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.23 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.2 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.18 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.14 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762956 c.-414G>C upstream_gene_variant 0.46 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.35 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.35 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.23 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.22 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.21 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763038 c.3232_3234delACCinsGG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.24 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.21 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763075 p.Thr1090Ile missense_variant 0.23 rifampicin
rpoB 763077 p.Val1091Leu missense_variant 0.2 rifampicin
rpoC 763082 c.-288C>A upstream_gene_variant 0.2 rifampicin
rpoC 763462 c.93G>C synonymous_variant 0.2 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763496 p.Lys43Arg missense_variant 0.31 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.48 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.49 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.53 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.61 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763622 p.Ala85Ser missense_variant 0.49 rifampicin Uncertain significance
rpoC 763633 c.264T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>A synonymous_variant 0.46 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.41 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.36 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.32 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.31 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.36 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.33 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.36 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.36 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.31 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.38 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.29 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.31 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.32 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsAC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.47 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.48 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.59 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.61 rifampicin
rpoC 764650 c.1281G>A synonymous_variant 0.62 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>T synonymous_variant 0.6 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.49 rifampicin Uncertain significance
rpoC 764714 c.1345_1347delCTGinsAC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.49 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>T synonymous_variant 0.46 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.39 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764804 c.1435_1436delCAinsG frameshift_variant&missense_variant 0.37 rifampicin
rpoC 764812 c.1443_1446delCCAAinsGCGCCGAG frameshift_variant&missense_variant 0.34 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.29 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
embR 1416666 p.Tyr228His missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472114 n.269A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472508 n.663T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472583 n.738T>G non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472585 n.740A>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472791 n.946G>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473065 n.1220C>A non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474288 n.631_647delCCTTTTCCTCTCCGGAGinsTCCCTT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474534 n.877G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>G non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474801 n.1144G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474917 n.1260G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474934 n.1277C>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474935 n.1278A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475061 n.1404delCinsATG non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475697 n.2040C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475702 n.2045G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475752 n.2095C>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475880 n.2223C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475882 n.2225C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476000 n.2343G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476248 n.2591G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476259 n.2602C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476288 n.2631T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 p.Glu40Asp missense_variant 0.2 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.19 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1833739 c.198C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.19 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.4 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834025 p.Gln162Ala missense_variant 0.27 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.27 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.27 pyrazinamide
rpsA 1834043 p.Glu168Lys missense_variant 0.27 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.27 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834240 c.699T>A synonymous_variant 0.24 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834318 c.777C>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834327 c.786G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834384 c.843A>G synonymous_variant 0.43 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.46 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834415 p.Ala292Gln missense_variant 0.47 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.43 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2064438 c.291G>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin
amikacin Not assoc w R - Interim
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
folC 2746171 c.1428G>A synonymous_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626476 c.138C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039559 c.1146C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039577 c.1128T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039588 p.Ser373Thr missense_variant 0.16 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039631 p.Ile358Met missense_variant 0.17 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039697 c.1008C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.13 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 0.98 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267034 c.1803C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R