Run ID: ERR4796544
Sample name:
Date: 20-10-2023 01:50:13
Number of reads: 3812571
Percentage reads mapped: 99.64
Strain: lineage3
Drug-resistance: Pre-XDR-TB
| Drug | Resistance | Supporting mutations |
|---|---|---|
| Rifampicin | R | rpoB p.Ser450Leu (1.00) |
| Isoniazid | R | katG p.Ser315Thr (1.00) |
| Ethambutol | R | embB p.Met306Val (1.00) |
| Pyrazinamide | ||
| Streptomycin | R | gid c.351delG (1.00) |
| Fluoroquinolones | R | gyrB p.Asn499Thr (0.99) |
| Moxifloxacin | R | gyrB p.Asn499Thr (0.99) |
| Ofloxacin | R | gyrB p.Asn499Thr (0.99) |
| Levofloxacin | R | gyrB p.Asn499Thr (0.99) |
| Ciprofloxacin | R | gyrB p.Asn499Thr (0.99) |
| Aminoglycosides | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin | ||
| Cycloserine | ||
| Ethionamide | R | ethA c.1047delT (1.00), ethA c.1047delT (1.00) |
| Clofazimine | ||
| Para-aminosalicylic_acid | ||
| Delamanid | ||
| Bedaquiline | ||
| Linezolid |
| Lineage | Family | Main Spoligotype | RDs | Frequency |
|---|---|---|---|---|
| lineage3 | East-African-Indian | CAS | RD750 | 1.0 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
|---|---|---|---|---|---|
| gyrB | 6735 | p.Asn499Thr | missense_variant | 0.99 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
| rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
| katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
| embB | 4247429 | p.Met306Val | missense_variant | 1.0 | ethambutol |
| ethA | 4326426 | c.1047delT | frameshift_variant | 1.0 | ethionamide, ethionamide |
| gid | 4407851 | c.351delG | frameshift_variant | 1.0 | streptomycin |
| Gene | Chromosome position | Mutation | Type | Estimated fraction |
|---|---|---|---|---|
| gyrB | 6963 | p.Arg575His | missense_variant | 1.0 |
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 |
| mshA | 576108 | p.Ala254Gly | missense_variant | 0.38 |
| ccsA | 620622 | c.732G>A | synonymous_variant | 1.0 |
| rpoB | 759746 | c.-61C>T | upstream_gene_variant | 1.0 |
| rpoB | 761315 | c.1510_1512dupGGG | conservative_inframe_insertion | 1.0 |
| rpoC | 762434 | c.-936T>G | upstream_gene_variant | 1.0 |
| rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 |
| mmpL5 | 776181 | p.Asp767Ala | missense_variant | 1.0 |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
| pncA | 2289365 | c.-125delC | upstream_gene_variant | 1.0 |
| ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 1.0 |
| thyX | 3067988 | c.-43A>C | upstream_gene_variant | 0.28 |
| thyA | 3073768 | p.Arg235Leu | missense_variant | 0.26 |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
| alr | 3841590 | c.-170G>A | upstream_gene_variant | 1.0 |
| embC | 4242075 | p.Arg738Gln | missense_variant | 1.0 |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
| aftB | 4268719 | p.Asn40Asp | missense_variant | 1.0 |
| ethR | 4327891 | p.Gly115Arg | missense_variant | 1.0 |
| whiB6 | 4338445 | c.76delC | frameshift_variant | 1.0 |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 |
