TB-Profiler result

Run: ERR4798262
Summary

Run ID: ERR4798262

Sample name:

Date: 2024-03-27T03:26:59.631220

Number of reads: 1682370

Percentage reads mapped: 42.25

Median coverage: 58.0

Strain: La1.2.BCG

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.2
La1 M.bovis None 0.09
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ile335Thr Mutation from literature
c.877_879delCTGinsAC Assoc w R High-level resistance
c.496_498delGTTinsAC Assoc w R High-level resistance
ethambutol embB p.His312Arg Mutation from literature
p.Ala388Gly Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.166_168delTCCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.202_204delCTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.409_411delGGGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.421_423delCAGinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.654_657delTGAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.662_663insGCAA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.916_918delTTCinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2182_2184delGATinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2251_2253delTTGinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiA c.358_360delCAGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490948 c.166_168delTCCinsGG frameshift_variant&missense_variant 0.76 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 490984 c.202_204delCTGinsAC frameshift_variant&missense_variant 0.76 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.8 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491191 c.409_411delGGGinsCC frameshift_variant&missense_variant 0.87 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491203 c.421_423delCAGinsGA frameshift_variant&missense_variant 0.87 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491434 c.654_657delTGAC frameshift_variant 0.71 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491444 c.662_663insGCAA frameshift_variant 0.71 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.77 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.6 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303846 c.916_918delTTCinsGA frameshift_variant&missense_variant 0.66 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305112 c.2182_2184delGATinsCA frameshift_variant&missense_variant 0.5 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305181 c.2251_2253delTTGinsCT frameshift_variant&synonymous_variant 0.51 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.5 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance Mutation from literature
katG 2155107 p.Ile335Thr missense_variant 0.59 isoniazid Mutation from literature
katG 2155233 c.877_879delCTGinsAC frameshift_variant&missense_variant 0.54 isoniazid Assoc w R High-level resistance
katG 2155614 c.496_498delGTTinsAC frameshift_variant&missense_variant 0.74 isoniazid Assoc w R High-level resistance
fbiA 3640900 c.358_360delCAGinsAC frameshift_variant&missense_variant 0.61 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.8 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.42 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 24 c.24C>A synonymous_variant 0.67 isoniazid
dnaA 30 c.30C>G synonymous_variant 0.64 isoniazid
dnaA 41 p.Asn14Ser missense_variant 0.6 isoniazid
dnaA 45 c.45G>A synonymous_variant 0.59 isoniazid
dnaA 624 c.624C>T synonymous_variant 0.75 isoniazid Not assoc w R - Interim
dnaA 633 c.633T>C synonymous_variant 0.77 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.82 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.77 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.81 isoniazid
dnaA 666 c.666C>A synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 672 c.672T>C synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 675 c.675C>A synonymous_variant 0.81 isoniazid
dnaA 678 c.678A>G synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 682 c.682T>C synonymous_variant 0.81 isoniazid
dnaA 687 c.687C>T synonymous_variant 0.81 isoniazid
dnaA 690 c.690G>C synonymous_variant 0.79 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.81 isoniazid
dnaA 702 c.702C>G synonymous_variant 0.81 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.76 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.76 isoniazid
dnaA 711 c.711C>G synonymous_variant 0.77 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.87 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.85 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.86 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.85 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.84 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.79 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.81 isoniazid
dnaA 810 c.810C>G synonymous_variant 0.82 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.82 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.82 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.8 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.8 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.81 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.81 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.82 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.8 isoniazid
dnaA 876 c.876C>T synonymous_variant 0.82 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.82 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.83 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.82 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.8 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.81 isoniazid
dnaA 924 c.924C>G synonymous_variant 0.82 isoniazid
dnaA 955 c.955_957delAGAinsCG frameshift_variant&synonymous_variant 0.81 isoniazid Uncertain significance
dnaA 963 c.963C>G synonymous_variant 0.78 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.78 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.76 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.76 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 1002 c.1002G>A synonymous_variant 0.76 isoniazid
dnaA 1014 c.1014C>G synonymous_variant 0.73 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.64 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.64 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.63 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.59 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.54 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.54 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.53 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.51 isoniazid
dnaA 1053 c.1053C>G synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 1068 c.1068T>C synonymous_variant 0.45 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.39 isoniazid
dnaA 1078 c.1078_1080delCTCinsTG frameshift_variant&missense_variant 0.39 isoniazid Uncertain significance
dnaA 1092 c.1092T>C synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.59 isoniazid
dnaA 1110 c.1110T>G synonymous_variant 0.53 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.54 isoniazid
dnaA 1116 c.1116C>G synonymous_variant 0.53 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.51 isoniazid
dnaA 1125 c.1125G>T synonymous_variant 0.49 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.53 isoniazid
dnaA 1137 c.1137C>T synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 1149 c.1149C>G synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.62 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.64 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.64 isoniazid
dnaA 1167 c.1167A>C synonymous_variant 0.65 isoniazid
dnaA 1176 c.1176A>G synonymous_variant 0.66 isoniazid
dnaA 1180 c.1180C>T synonymous_variant 0.66 isoniazid Not assoc w R - Interim
dnaA 1185 c.1185C>G synonymous_variant 0.68 isoniazid Not assoc w R - Interim
dnaA 1191 c.1191T>C synonymous_variant 0.71 isoniazid
dnaA 1200 c.1200C>G synonymous_variant 0.71 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.73 isoniazid
dnaA 1224 c.1224C>G synonymous_variant 0.75 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.79 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.78 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.76 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.72 isoniazid
dnaA 1291 c.1291_1293delCTTinsTG frameshift_variant&missense_variant 0.71 isoniazid Uncertain significance
dnaA 1299 c.1299G>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
dnaA 1314 c.1314A>G synonymous_variant 0.67 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.66 isoniazid
dnaA 1318 c.1318C>T synonymous_variant 0.66 isoniazid
dnaA 1323 c.1323C>G synonymous_variant 0.66 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.63 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.59 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.57 isoniazid Not assoc w R - Interim
dnaA 1371 c.1371T>G synonymous_variant 0.52 isoniazid
dnaA 1380 c.1380C>G synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 1383 c.1383A>G synonymous_variant 0.42 isoniazid
dnaA 1389 c.1389C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
gyrB 6086 p.Thr283Ala missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6091 c.852G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6103 c.864G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6109 c.870G>A synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6112 p.Met291Ile missense_variant 0.65 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6115 c.876A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6121 c.882C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.38 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrB 6199 c.960C>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrB 6235 c.996C>A synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.82 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6251 c.1012C>T synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6256 c.1017G>A synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6388 c.-914T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6589 c.-713G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6594 p.Lys452Arg missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6674 c.1435_1437delCTTinsTG frameshift_variant&missense_variant 0.59 levofloxacin Uncertain significance
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6748 c.-554G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.6 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6901 c.-401G>A upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>A upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7210 c.-92C>T upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7237 c.-65C>T upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.85 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7496 c.195C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7508 c.207C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7619 c.318C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7622 c.321C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 7691 c.390C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7697 c.396C>A synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7781 c.480G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>T synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8348 c.1047C>G synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.78 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8405 c.1104C>T synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8525 c.1224C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8526 c.1225C>A synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8567 p.Ile422Met missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8744 p.Asp481Glu missense_variant 0.68 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8750 c.1449C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8752 p.Ala484Gly missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.56 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.65 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.66 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.81 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>A synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8983 p.Cys561Ser missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.79 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9008 c.1707C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.68 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.76 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9260 c.1959G>C synonymous_variant 0.73 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9261 c.1960_1962delCGCinsAG frameshift_variant&missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9311 c.2010C>T synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9326 c.2025G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>A synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>A synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.66 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13304 c.255G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490777 c.-6G>T upstream_gene_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 490809 c.27A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.61 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 490867 p.Ala29Ser missense_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 490959 c.177C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Thr missense_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491031 c.249C>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491103 c.321C>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.89 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491229 c.447C>T synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.85 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491296 p.Val172Ile missense_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>A synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.78 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491355 c.573C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491379 c.597C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491397 c.615G>A synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491409 c.627G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491412 c.630G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491415 c.633A>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491418 c.636A>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491421 c.639A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491430 c.648T>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491453 p.Gly224Asp missense_variant 0.82 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491455 p.Ile225Val missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491589 c.807G>A synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491652 c.870C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491685 c.903G>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.76 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491697 c.915G>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574559 c.-789T>G upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 574565 c.-783T>G upstream_gene_variant 0.43 ethionamide
isoniazid
mshA 574586 c.-762G>C upstream_gene_variant 0.42 ethionamide
isoniazid
mshA 574589 c.-759T>C upstream_gene_variant 0.44 ethionamide
isoniazid
mshA 574592 c.-756C>G upstream_gene_variant 0.42 ethionamide
isoniazid
mshA 574595 c.-753A>G upstream_gene_variant 0.42 ethionamide
isoniazid
mshA 574604 c.-744C>G upstream_gene_variant 0.45 ethionamide
isoniazid
mshA 574605 c.-743G>C upstream_gene_variant 0.45 ethionamide
isoniazid
mshA 574616 c.-732G>C upstream_gene_variant 0.48 ethionamide
isoniazid
mshA 574631 c.-717C>G upstream_gene_variant 0.55 ethionamide
isoniazid
mshA 574640 c.-708G>C upstream_gene_variant 0.55 ethionamide
isoniazid
mshA 574650 c.-698A>C upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574659 c.-689A>C upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574673 c.-675A>G upstream_gene_variant 0.61 ethionamide
isoniazid
mshA 574679 c.-669C>T upstream_gene_variant 0.62 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 574683 c.-665T>C upstream_gene_variant 0.62 ethionamide
isoniazid Uncertain significance
mshA 574694 c.-654C>G upstream_gene_variant 0.63 ethionamide
isoniazid
mshA 574712 c.-636A>G upstream_gene_variant 0.6 ethionamide
isoniazid
mshA 574718 c.-630A>G upstream_gene_variant 0.6 ethionamide
isoniazid
mshA 574724 c.-624T>C upstream_gene_variant 0.55 ethionamide
isoniazid
mshA 574731 c.-617A>G upstream_gene_variant 0.59 ethionamide
isoniazid
mshA 574739 c.-609T>C upstream_gene_variant 0.61 ethionamide
isoniazid
mshA 574742 c.-606G>C upstream_gene_variant 0.61 ethionamide
isoniazid
mshA 574763 c.-585T>C upstream_gene_variant 0.59 ethionamide
isoniazid Uncertain significance
mshA 574766 c.-582T>C upstream_gene_variant 0.59 ethionamide
isoniazid Uncertain significance
mshA 574769 c.-579C>G upstream_gene_variant 0.59 ethionamide
isoniazid
mshA 574781 c.-567G>C upstream_gene_variant 0.54 ethionamide
isoniazid
mshA 574782 c.-566_-564delCCCinsGG upstream_gene_variant 0.54 ethionamide
isoniazid
mshA 574799 c.-549T>C upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 574802 c.-546A>G upstream_gene_variant 0.33 ethionamide
isoniazid
mshA 574803 c.-545A>C upstream_gene_variant 0.33 ethionamide
isoniazid
mshA 574814 c.-534T>C upstream_gene_variant 0.32 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.42 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.55 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.56 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.58 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.54 ethionamide
isoniazid Not assoc w R - Interim
mshA 575641 c.294A>G synonymous_variant 0.51 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.44 ethionamide
isoniazid
mshA 575653 c.306G>C synonymous_variant 0.43 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.44 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575674 c.327G>C synonymous_variant 0.52 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.56 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.53 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.53 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.57 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.59 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.56 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.58 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.58 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.6 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.6 ethionamide
isoniazid
mshA 575786 p.Tyr147His missense_variant 0.6 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.6 ethionamide
isoniazid Not assoc w R - Interim
mshA 575806 c.459G>C synonymous_variant 0.6 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.62 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.67 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.66 ethionamide
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.67 ethionamide
isoniazid
mshA 575875 c.528C>G synonymous_variant 0.62 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.62 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.57 ethionamide
isoniazid
mshA 575899 c.552G>A synonymous_variant 0.56 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.5 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.47 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575984 c.637T>C synonymous_variant 0.34 ethionamide
isoniazid
ccsA 619506 c.-385A>T upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619573 c.-318G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619588 c.-303C>G upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620208 c.318G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 620246 p.Leu119Cys missense_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620253 c.363G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Leu missense_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>G synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620290 p.Tyr134His missense_variant 0.56 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
ccsA 620295 c.405G>C synonymous_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620296 c.406_408delCCGinsGC frameshift_variant&missense_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>A synonymous_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 620316 c.426G>C synonymous_variant 0.6 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620340 c.450C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620343 c.453G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.36 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620430 c.540C>T synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.38 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620439 c.549T>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620449 p.Leu187Met missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620454 c.564C>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620559 c.669A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620569 c.679_681delGGAinsCC frameshift_variant&missense_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620583 c.693G>C synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620597 p.Ala236Gly missense_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>T synonymous_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.65 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.76 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620691 c.801G>T synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>A synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.78 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620766 c.876C>G synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.7 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620781 c.891C>G synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>T synonymous_variant 0.67 capreomycin
amikacin
kanamycin
ccsA 620793 c.903G>C synonymous_variant 0.67 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.68 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620829 c.939G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620832 c.942C>T synonymous_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620835 c.945C>G synonymous_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620844 c.954C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620856 c.966C>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
Rv0565c 656184 c.1287G>C synonymous_variant 0.38 ethionamide
Rv0565c 656189 p.Glu428Gln missense_variant 0.38 ethionamide
Rv0565c 656196 c.1275G>C synonymous_variant 0.38 ethionamide
Rv0565c 656206 p.Ala422Tyr missense_variant 0.41 ethionamide
Rv0565c 656212 p.Arg420His missense_variant 0.45 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.46 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.48 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.5 ethionamide Not assoc w R - Interim
Rv0565c 656228 p.Ala415Ser missense_variant 0.5 ethionamide
Rv0565c 656238 c.1233A>G synonymous_variant 0.55 ethionamide
Rv0565c 656244 c.1227A>G synonymous_variant 0.53 ethionamide
Rv0565c 656247 c.1224A>G synonymous_variant 0.52 ethionamide
Rv0565c 656256 c.1215G>C synonymous_variant 0.53 ethionamide
Rv0565c 656262 c.1209C>G synonymous_variant 0.55 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.55 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.55 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.57 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.55 ethionamide
Rv0565c 656292 c.1179G>C synonymous_variant 0.55 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.53 ethionamide
Rv0565c 656310 c.1161T>C synonymous_variant 0.49 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.29 ethionamide
Rv0565c 656424 c.1047G>A synonymous_variant 0.28 ethionamide
Rv0565c 656436 c.1035C>G synonymous_variant 0.29 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.28 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.3 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.31 ethionamide
Rv0565c 656467 p.Gly335Ala missense_variant 0.31 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.27 ethionamide Not assoc w R - Interim
Rv0565c 656523 c.948G>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 657563 c.-93T>C upstream_gene_variant 0.48 ethionamide
Rv0565c 657571 c.-101T>C upstream_gene_variant 0.62 ethionamide
Rv0565c 657572 c.-102A>G upstream_gene_variant 0.67 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.74 ethionamide
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.73 ethionamide
Rv0565c 657602 c.-132C>G upstream_gene_variant 0.76 ethionamide
Rv0565c 657644 c.-174G>C upstream_gene_variant 0.81 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.86 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.91 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.91 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.88 ethionamide
hadA 731711 c.-219T>C upstream_gene_variant 0.45 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.65 isoniazid
hadA 731748 c.-182T>C upstream_gene_variant 0.65 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.67 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.69 isoniazid
hadA 731774 c.-156T>G upstream_gene_variant 0.63 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.68 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.65 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.65 isoniazid
hadA 731817 c.-113C>A upstream_gene_variant 0.64 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.55 isoniazid
hadA 731859 c.-71G>C upstream_gene_variant 0.5 isoniazid
hadA 731934 p.Ala2Gly missense_variant 0.61 isoniazid
hadA 731939 c.10_11delAGinsTC synonymous_variant 0.58 isoniazid
hadA 731942 p.Ala5Thr missense_variant 0.58 isoniazid
hadA 731953 c.24T>C synonymous_variant 0.65 isoniazid
hadA 731962 c.33T>C synonymous_variant 0.63 isoniazid
hadA 731965 c.36C>T synonymous_variant 0.65 isoniazid
hadA 731995 c.66G>C synonymous_variant 0.72 isoniazid
hadA 732004 c.75T>C synonymous_variant 0.72 isoniazid
hadA 732010 c.81G>A synonymous_variant 0.72 isoniazid Not assoc w R - Interim
hadA 732016 c.87C>G synonymous_variant 0.72 isoniazid Not assoc w R - Interim
hadA 732019 c.90C>G synonymous_variant 0.7 isoniazid
hadA 732025 c.96T>G synonymous_variant 0.7 isoniazid
hadA 732028 c.99A>G synonymous_variant 0.71 isoniazid
hadA 732032 p.Asp35Thr missense_variant 0.72 isoniazid
hadA 732040 c.111G>C synonymous_variant 0.72 isoniazid
hadA 732045 p.Tyr39Phe missense_variant 0.71 isoniazid
hadA 732060 p.Gly44Ala missense_variant 0.67 isoniazid
hadA 732070 c.141A>G synonymous_variant 0.66 isoniazid
hadA 732073 c.144C>G synonymous_variant 0.61 isoniazid
hadA 732076 c.147G>T synonymous_variant 0.61 isoniazid
hadA 732079 c.150T>C synonymous_variant 0.61 isoniazid Not assoc w R - Interim
hadA 732086 c.157T>C synonymous_variant 0.66 isoniazid Not assoc w R - Interim
hadA 732089 c.160C>T synonymous_variant 0.64 isoniazid
hadA 732094 c.165T>G synonymous_variant 0.68 isoniazid
hadA 732098 c.169T>C synonymous_variant 0.67 isoniazid
hadA 732106 c.177T>C synonymous_variant 0.66 isoniazid
hadA 732125 p.Lys66Gln missense_variant 0.65 isoniazid
hadA 732130 c.201C>G synonymous_variant 0.65 isoniazid
hadA 732133 c.204G>A synonymous_variant 0.67 isoniazid Not assoc w R - Interim
hadA 732134 p.Ala69Ser missense_variant 0.67 isoniazid
hadA 732151 c.222T>C synonymous_variant 0.68 isoniazid
hadA 732157 p.Asn76Lys missense_variant 0.68 isoniazid
hadA 732163 c.234G>C synonymous_variant 0.66 isoniazid
hadA 732164 p.Thr79Val missense_variant 0.66 isoniazid
hadA 732168 p.Ala80Glu missense_variant 0.68 isoniazid
hadA 732172 p.Glu81Asp missense_variant 0.68 isoniazid
hadA 732190 c.261A>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
hadA 732193 c.264C>T synonymous_variant 0.68 isoniazid
hadA 732196 c.267A>G synonymous_variant 0.68 isoniazid
hadA 732204 p.Lys92Arg missense_variant 0.71 isoniazid
hadA 732209 p.Glu94Arg missense_variant 0.7 isoniazid
hadA 732214 c.285A>G synonymous_variant 0.7 isoniazid Not assoc w R - Interim
hadA 732238 c.309G>C synonymous_variant 0.69 isoniazid
hadA 732241 c.312C>T synonymous_variant 0.69 isoniazid
hadA 732250 c.321C>G synonymous_variant 0.66 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.67 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.69 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.64 isoniazid
hadA 732272 p.Ala115Thr missense_variant 0.63 isoniazid Uncertain significance
hadA 732278 p.Gly117Gln missense_variant 0.61 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.62 isoniazid
hadA 732314 p.Asn129Asp missense_variant 0.61 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.58 isoniazid
hadA 732329 c.400_402delCTCinsAT frameshift_variant&missense_variant 0.54 isoniazid Uncertain significance
hadA 732346 c.417T>C synonymous_variant 0.72 isoniazid
hadA 732367 c.438C>G synonymous_variant 0.7 isoniazid
hadA 732370 c.441C>T synonymous_variant 0.71 isoniazid
hadA 732373 c.444G>A synonymous_variant 0.71 isoniazid
hadA 732382 c.453delGinsAAAA conservative_inframe_insertion&synonymous_variant 0.7 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.74 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.72 isoniazid
nusG 734111 c.-143A>G upstream_gene_variant 0.33 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.39 rifampicin
nusG 734116 c.-138T>C upstream_gene_variant 0.58 rifampicin Not assoc w R
nusG 734120 c.-134T>C upstream_gene_variant 0.5 rifampicin Uncertain significance
nusG 734129 c.-125G>C upstream_gene_variant 0.61 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.64 rifampicin
nusG 734170 c.-83_-81delCGC upstream_gene_variant 0.61 rifampicin
nusG 734177 c.-77_-76insCTG upstream_gene_variant 0.6 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.61 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.6 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.6 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.59 rifampicin
nusG 734208 c.-46T>C upstream_gene_variant 0.59 rifampicin
nusG 734224 c.-30G>C upstream_gene_variant 0.59 rifampicin
nusG 734225 c.-29C>T upstream_gene_variant 0.59 rifampicin
nusG 734227 c.-27C>T upstream_gene_variant 0.59 rifampicin
nusG 734239 c.-15A>G upstream_gene_variant 0.57 rifampicin Uncertain significance
nusG 734240 c.-14G>A upstream_gene_variant 0.57 rifampicin
nusG 734246 c.-8T>C upstream_gene_variant 0.57 rifampicin
nusG 734261 p.Thr3Ser missense_variant 0.58 rifampicin
nusG 734403 c.150C>T synonymous_variant 0.32 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.34 rifampicin
nusG 734418 c.165C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734424 c.171G>A synonymous_variant 0.34 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.48 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.6 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.68 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.73 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.64 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.58 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.54 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.36 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.39 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.37 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.37 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.37 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.37 rifampicin
nusG 734719 p.Ser156Ala missense_variant 0.37 rifampicin
nusG 734722 p.Thr157Ala missense_variant 0.37 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.4 rifampicin
nusG 734731 c.478_480delGCTinsAA frameshift_variant&missense_variant 0.45 rifampicin
nusG 734742 c.489T>C synonymous_variant 0.57 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.54 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.54 rifampicin
nusG 734762 p.Ala170Val missense_variant 0.54 rifampicin
nusG 734778 c.525G>C synonymous_variant 0.58 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.6 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.6 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.6 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.64 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.62 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.57 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.51 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.49 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.49 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.5 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.35 rifampicin
rpoB 759546 c.-261A>G upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760046 c.240G>C synonymous_variant 0.32 rifampicin
rpoB 760067 c.261G>T synonymous_variant 0.49 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.54 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>G synonymous_variant 0.78 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.78 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.79 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.81 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.8 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.82 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.82 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.81 rifampicin
rpoB 760343 c.537G>C synonymous_variant 0.8 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.8 rifampicin Uncertain significance
rpoB 760381 p.Thr192Ile missense_variant 0.79 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.77 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.71 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.24 rifampicin Not assoc w R
rpoB 760511 c.705G>C synonymous_variant 0.77 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.77 rifampicin Uncertain significance
rpoB 760528 p.Gln241Arg missense_variant 0.74 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.75 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.78 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.82 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.79 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760664 c.858G>A synonymous_variant 0.69 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760716 c.910_912delCGCinsAG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 760859 c.1053T>G synonymous_variant 0.48 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.58 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.71 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.71 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761003 c.1197C>G synonymous_variant 0.86 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.81 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.81 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.82 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.83 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.81 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.82 rifampicin
rpoB 761186 c.1380G>A synonymous_variant 0.82 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.82 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.84 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.86 rifampicin
rpoB 761348 c.1542C>G synonymous_variant 0.86 rifampicin
rpoB 761354 c.1548C>G synonymous_variant 0.86 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.86 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.85 rifampicin
rpoB 761390 c.1584C>T synonymous_variant 0.9 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.88 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.88 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.88 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.88 rifampicin
rpoB 761457 p.Pro551Lys missense_variant 0.89 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.84 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.84 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.83 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.82 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>G synonymous_variant 0.83 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.82 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.7 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.71 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.7 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.67 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.66 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.61 rifampicin
rpoB 761726 c.1920A>G synonymous_variant 0.49 rifampicin
rpoB 761727 c.1921_1922delAGinsTC synonymous_variant 0.49 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.62 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.65 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.65 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.68 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.69 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.69 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.68 rifampicin
rpoB 761807 c.2001C>T synonymous_variant 0.65 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.6 rifampicin
rpoB 761831 c.2025C>A synonymous_variant 0.58 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.61 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.62 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.63 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.68 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.7 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.73 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.68 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.65 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.68 rifampicin
rpoB 761913 c.2107_2109delGACinsCG frameshift_variant&missense_variant 0.67 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.68 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.72 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.73 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.83 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.88 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.88 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.86 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.86 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>G synonymous_variant 0.87 rifampicin
rpoB 762167 c.2361T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.86 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.83 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.82 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.8 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.78 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.78 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.8 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.8 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.79 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.81 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.82 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.8 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.8 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.78 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.76 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.75 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.82 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.85 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.85 rifampicin
rpoB 762491 c.2685T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762510 p.Ala902Pro missense_variant 0.78 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.78 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.77 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.77 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.77 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.82 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.74 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.75 rifampicin
rpoC 762596 c.-774G>C upstream_gene_variant 0.69 rifampicin
rpoB 762599 c.2793T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 762605 c.-765T>C upstream_gene_variant 0.7 rifampicin
rpoC 762608 c.-762C>G upstream_gene_variant 0.71 rifampicin
rpoB 762630 c.2824_2826delGCCinsAG frameshift_variant&missense_variant 0.61 rifampicin
rpoB 762633 p.Ala943Ser missense_variant 0.61 rifampicin
rpoC 762641 c.-729G>C upstream_gene_variant 0.53 rifampicin
rpoB 762725 c.2919C>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 762728 c.-642C>G upstream_gene_variant 0.71 rifampicin
rpoB 762749 c.2943C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762753 c.2947T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.72 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.72 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 762794 c.-576C>G upstream_gene_variant 0.76 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.77 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.78 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.91 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.88 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.89 rifampicin
rpoC 763136 c.-234C>G upstream_gene_variant 0.88 rifampicin
rpoC 763157 c.-213G>C upstream_gene_variant 0.89 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.86 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.83 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.83 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>C upstream_gene_variant 0.79 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.79 rifampicin
rpoC 763235 c.-135A>G upstream_gene_variant 0.76 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763247 c.-123G>A upstream_gene_variant 0.74 rifampicin
rpoB 763272 c.3466C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.72 rifampicin
rpoC 763430 c.61A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.79 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.86 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.86 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.83 rifampicin
rpoC 763654 c.285C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.86 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.87 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.88 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.88 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.91 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.91 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.91 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.89 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.89 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.91 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.89 rifampicin
rpoC 763876 c.507A>G synonymous_variant 0.88 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.88 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.87 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.87 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.87 rifampicin
rpoC 763912 c.543G>C synonymous_variant 0.86 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763939 c.570G>A synonymous_variant 0.86 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763963 c.594C>G synonymous_variant 0.87 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.87 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.84 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.85 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.84 rifampicin
rpoC 764023 c.654G>C synonymous_variant 0.86 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.86 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.86 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.85 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.86 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.85 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.85 rifampicin
rpoC 764095 c.726C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.86 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.85 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.82 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.82 rifampicin
rpoC 764209 c.840C>G synonymous_variant 0.82 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.82 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.83 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.84 rifampicin
rpoC 764245 c.876C>G synonymous_variant 0.83 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.85 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.84 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.85 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.86 rifampicin
rpoC 764290 c.921C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764329 c.960C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.83 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.82 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.82 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.78 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.78 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764479 c.1110G>A synonymous_variant 0.83 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.84 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>G synonymous_variant 0.82 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.87 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.89 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.89 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.86 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.83 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 0.82 rifampicin
rpoC 764713 c.1344G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.81 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.83 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.85 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.83 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.8 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.75 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639_1641delTTGinsCC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.49 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.49 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>T synonymous_variant 0.49 rifampicin
rpoC 765034 c.1665T>G synonymous_variant 0.49 rifampicin
rpoC 765037 c.1668C>G synonymous_variant 0.49 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.49 rifampicin
rpoC 765076 c.1707A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>C synonymous_variant 0.51 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.55 rifampicin
rpoC 765103 c.1734G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765292 c.1923G>T synonymous_variant 0.59 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.59 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.6 rifampicin Uncertain significance
rpoC 765313 c.1944C>T synonymous_variant 0.58 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765325 c.1956C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Val missense_variant 0.54 rifampicin
rpoC 765330 p.Ser654Asn missense_variant 0.55 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765403 c.2034G>C synonymous_variant 0.68 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.69 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.68 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.69 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.77 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.82 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.82 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.82 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.84 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.83 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.83 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.89 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.87 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.87 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.88 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.86 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.88 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.88 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.87 rifampicin
rpoC 765805 c.2436C>G synonymous_variant 0.88 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.87 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.87 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.85 rifampicin
rpoC 766003 c.2634G>C synonymous_variant 0.85 rifampicin
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.86 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.86 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.87 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.86 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.84 rifampicin
rpoC 766066 c.2697C>G synonymous_variant 0.8 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.79 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.79 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.76 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>G synonymous_variant 0.8 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.79 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.77 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766193 c.2824_2826delCAAinsGG frameshift_variant&missense_variant 0.77 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.82 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766222 c.2853T>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766226 c.2857T>C synonymous_variant 0.8 rifampicin
rpoC 766231 c.2862T>G synonymous_variant 0.81 rifampicin
rpoC 766234 c.2865T>G synonymous_variant 0.81 rifampicin
rpoC 766237 c.2868T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.8 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.8 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.81 rifampicin
rpoC 766285 c.2916C>G synonymous_variant 0.83 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.83 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.81 rifampicin
rpoC 766312 c.2943T>A synonymous_variant 0.78 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.78 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766366 c.2997C>G synonymous_variant 0.77 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.76 rifampicin
rpoC 766378 c.3009C>T synonymous_variant 0.75 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.76 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.74 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.76 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.78 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.78 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.76 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.74 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.75 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.74 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.75 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.76 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.78 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.8 rifampicin
rpoC 766526 c.3157_3159delGTTinsAC frameshift_variant&missense_variant 0.8 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.8 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.82 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.82 rifampicin
rpoC 766568 p.Val1067Ile missense_variant 0.82 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.82 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.86 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.83 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.82 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.86 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.91 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 0.95 rifampicin
rpoC 766627 c.3258G>C synonymous_variant 0.96 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.96 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.96 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.91 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.91 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.91 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 0.91 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.91 rifampicin
rpoC 766686 p.Glu1106Val missense_variant 0.91 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.88 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.84 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.86 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.88 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.85 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.85 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.84 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.84 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.87 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.92 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.9 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.9 rifampicin
rpoC 767020 c.3651C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>G synonymous_variant 0.84 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.81 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.81 rifampicin
rpoC 767186 p.Gln1273Glu missense_variant 0.82 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767242 p.Gln1291His missense_variant 0.71 rifampicin
rpoC 767263 c.3894T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.55 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.46 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.45 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.46 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775847 c.2634G>C synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.36 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 0.35 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 775870 p.Ile871Val missense_variant 0.36 clofazimine
bedaquiline
mmpL5 775874 c.2607C>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 775883 p.Ile866Met missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.38 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775919 c.2562G>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 775949 c.2532G>C synonymous_variant 0.44 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.38 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.36 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776027 c.2454G>T synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 776039 c.2442C>G synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776042 c.2439C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776056 p.Val809Leu missense_variant 0.32 clofazimine
bedaquiline
mmpL5 776057 c.2424G>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 776066 c.2415C>G synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776129 c.2352C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 776132 c.2347_2349delGCAinsTG frameshift_variant&missense_variant 0.33 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776137 p.Ser782Ala missense_variant 0.31 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776395 p.Phe696Leu missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Uncertain significance
rpsL 781134 c.-426T>C upstream_gene_variant 0.43 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.52 streptomycin
rpsL 781592 c.33T>C synonymous_variant 0.59 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.66 streptomycin
rpsL 781634 c.75G>A synonymous_variant 0.78 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.78 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.77 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.8 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.84 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.83 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.84 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.84 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.83 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.83 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.84 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.83 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.83 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.82 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.81 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.82 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.83 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.82 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.83 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.83 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.84 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.83 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.83 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.83 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.81 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.79 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.78 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.76 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.76 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800516 c.-293G>C upstream_gene_variant 0.44 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.5 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.53 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.62 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.58 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.62 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.63 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.62 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.63 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.72 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.73 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.71 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.67 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.65 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.6 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.56 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.54 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.52 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.52 linezolid
rplC 800904 c.96G>C synonymous_variant 0.27 linezolid
rplC 800916 c.108A>G synonymous_variant 0.33 linezolid
rplC 800931 c.123G>A synonymous_variant 0.33 linezolid
rplC 800937 c.129A>G synonymous_variant 0.38 linezolid
rplC 800946 c.138T>C synonymous_variant 0.38 linezolid
rplC 800949 c.141T>C synonymous_variant 0.36 linezolid
rplC 800958 c.150G>C synonymous_variant 0.38 linezolid
rplC 800970 c.162T>C synonymous_variant 0.38 linezolid Not assoc w R - Interim
rplC 800985 c.177A>G synonymous_variant 0.38 linezolid
rplC 800988 c.180C>T synonymous_variant 0.39 linezolid
rplC 801004 p.Leu66Val missense_variant 0.51 linezolid
rplC 801009 c.201A>C synonymous_variant 0.5 linezolid
rplC 801027 c.219C>G synonymous_variant 0.52 linezolid
rplC 801039 c.231A>G synonymous_variant 0.52 linezolid
rplC 801045 c.237A>G synonymous_variant 0.53 linezolid
rplC 801063 c.255G>C synonymous_variant 0.54 linezolid
rplC 801070 p.Asp88Asn missense_variant 0.52 linezolid
rplC 801078 c.270T>C synonymous_variant 0.45 linezolid
rplC 801084 c.276G>C synonymous_variant 0.45 linezolid
rplC 801085 p.Thr93Ala missense_variant 0.44 linezolid Uncertain significance
rplC 801090 c.282G>A synonymous_variant 0.44 linezolid
rplC 801094 p.Gln96Glu missense_variant 0.44 linezolid
rplC 801099 c.291T>C synonymous_variant 0.5 linezolid
rplC 801102 c.294G>C synonymous_variant 0.5 linezolid
rplC 801105 c.297A>G synonymous_variant 0.52 linezolid
rplC 801109 c.301T>C synonymous_variant 0.54 linezolid Not assoc w R - Interim
rplC 801117 c.309G>C synonymous_variant 0.56 linezolid
rplC 801132 c.324T>C synonymous_variant 0.55 linezolid
rplC 801137 p.Ser110Thr missense_variant 0.57 linezolid
rplC 801147 c.339T>C synonymous_variant 0.41 linezolid
rplC 801153 c.345G>C synonymous_variant 0.41 linezolid
rplC 801156 c.348T>C synonymous_variant 0.41 linezolid
rplC 801165 c.357G>A synonymous_variant 0.45 linezolid Not assoc w R - Interim
rplC 801171 c.363A>G synonymous_variant 0.48 linezolid
rplC 801174 c.366T>C synonymous_variant 0.45 linezolid
rplC 801183 c.375C>A synonymous_variant 0.57 linezolid
rplC 801195 c.387G>C synonymous_variant 0.65 linezolid
rplC 801204 c.396C>T synonymous_variant 0.57 linezolid
rplC 801222 c.414T>C synonymous_variant 0.65 linezolid
rplC 801228 c.420T>C synonymous_variant 0.65 linezolid
rplC 801231 c.423C>G synonymous_variant 0.64 linezolid
rplC 801247 c.439_441delCGTinsAG frameshift_variant&missense_variant 0.68 linezolid
rplC 801255 c.447C>T synonymous_variant 0.7 linezolid
rplC 801267 c.459A>C synonymous_variant 0.69 linezolid
rplC 801270 c.462T>C synonymous_variant 0.68 linezolid
rplC 801276 c.468G>C synonymous_variant 0.69 linezolid
rplC 801285 c.477G>T synonymous_variant 0.7 linezolid
rplC 801288 c.480G>C synonymous_variant 0.71 linezolid
rplC 801312 c.504G>C synonymous_variant 0.73 linezolid
rplC 801324 c.516T>C synonymous_variant 0.74 linezolid
rplC 801339 c.531T>G synonymous_variant 0.7 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.7 linezolid
rplC 801348 c.540T>G synonymous_variant 0.71 linezolid
rplC 801357 c.549T>C synonymous_variant 0.72 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.71 linezolid
rplC 801396 c.588T>C synonymous_variant 0.64 linezolid
rplC 801402 c.594T>C synonymous_variant 0.6 linezolid
rplC 801405 c.597T>C synonymous_variant 0.61 linezolid
rplC 801408 c.600C>G synonymous_variant 0.61 linezolid
rplC 801420 c.612A>C synonymous_variant 0.56 linezolid
rplC 801423 c.615G>C synonymous_variant 0.53 linezolid
rplC 801426 c.618C>G synonymous_variant 0.55 linezolid
rplC 801438 c.630T>C synonymous_variant 0.62 linezolid
rplC 801442 p.Ile212Val missense_variant 0.65 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303051 p.Val41Met missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303425 c.495G>A synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303431 c.501T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303437 c.507C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303446 c.516C>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303449 c.519C>T synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303452 c.522G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>G synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.59 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303492 c.562T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303593 c.663G>T synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303646 p.Ala239Val missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303665 c.735G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303677 c.747C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303789 p.Ile287Val missense_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.69 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303878 c.948G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304104 c.1174C>T synonymous_variant 0.58 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304112 c.1182G>A synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304139 c.1209G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304465 p.Gly512Ala missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304472 c.1542T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304475 c.1545G>C synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304484 c.1554C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304490 c.1560C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304502 c.1572G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304601 c.1671C>T synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304604 c.1674C>T synonymous_variant 0.74 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304613 c.1683T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>A synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304637 c.1707G>A synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304718 c.1788C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.58 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>A synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304802 c.1872G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.73 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304891 p.Ile654Thr missense_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304901 c.1971C>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1305006 p.Glu692Asp missense_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305129 c.2199C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305135 c.2205C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1305154 c.2224T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1305174 c.2244T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>A synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305219 c.2289T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.58 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305309 c.2379G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305320 p.Gln797Arg missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
sigE 1364790 c.378T>C synonymous_variant 0.54 pyrazinamide
sigE 1364796 c.384G>A synonymous_variant 0.57 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.58 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.6 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.61 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.59 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.55 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.53 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.54 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.56 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.56 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.56 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.62 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.61 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.65 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.53 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.55 pyrazinamide Uncertain significance
sigE 1364958 c.546G>C synonymous_variant 0.55 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.55 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.59 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.59 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.56 pyrazinamide
sigE 1365003 c.591T>C synonymous_variant 0.69 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.69 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.66 pyrazinamide
sigE 1365036 c.624T>G synonymous_variant 0.58 pyrazinamide
sigE 1365037 c.625C>T synonymous_variant 0.55 pyrazinamide
sigE 1365063 c.651A>C synonymous_variant 0.56 pyrazinamide
sigE 1365072 c.660G>C synonymous_variant 0.48 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460804 c.-241T>C upstream_gene_variant 0.68 bedaquiline
atpE 1460807 c.-238C>T upstream_gene_variant 0.67 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.66 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.62 bedaquiline
atpE 1460837 c.-208C>G upstream_gene_variant 0.61 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.6 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.51 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.49 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.5 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.46 bedaquiline
atpE 1461068 c.24C>T synonymous_variant 0.61 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.65 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.68 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.69 bedaquiline
atpE 1461113 c.69C>A synonymous_variant 0.7 bedaquiline
atpE 1461125 c.81T>C synonymous_variant 0.71 bedaquiline
atpE 1461137 c.93C>G synonymous_variant 0.71 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.68 bedaquiline
atpE 1461150 c.106_108delATCinsGG frameshift_variant&missense_variant 0.68 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.69 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.67 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.68 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.68 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.64 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.64 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.61 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.53 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.52 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.45 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.4 bedaquiline
atpE 1461261 c.217C>T synonymous_variant 0.38 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTT non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473667 n.10T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473684 n.27G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474029 n.372G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474111 n.454T>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474289 n.632C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474292 n.635T>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474293 n.637_651delCCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474409 n.756_776delACCCACACGCGCATACGCGCG non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474414