Run ID: ERR4800575
Sample name:
Date: 20-10-2023 04:27:36
Number of reads: 4168393
Percentage reads mapped: 99.34
Strain: lineage3
Drug-resistance: Pre-XDR-TB
| Drug | Resistance | Supporting mutations |
|---|---|---|
| Rifampicin | R | rpoB p.Ser450Leu (1.00), rpoC p.Leu527Val (1.00) |
| Isoniazid | R | katG p.Ser315Thr (0.98) |
| Ethambutol | R | embB p.Met306Ile (1.00), embB p.Gln497Lys (0.99) |
| Pyrazinamide | ||
| Streptomycin | R | rpsL p.Lys88Thr (0.97) |
| Fluoroquinolones | R | gyrA p.Asp94Gly (0.99) |
| Moxifloxacin | R | gyrA p.Asp94Gly (0.99) |
| Ofloxacin | R | gyrA p.Asp94Gly (0.99) |
| Levofloxacin | R | gyrA p.Asp94Gly (0.99) |
| Ciprofloxacin | R | gyrA p.Asp94Gly (0.99) |
| Aminoglycosides | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin | ||
| Cycloserine | ||
| Ethionamide | R | ethA c.130dupA (0.99), ethA c.130dupA (0.99) |
| Clofazimine | ||
| Para-aminosalicylic_acid | ||
| Delamanid | ||
| Bedaquiline | ||
| Linezolid |
| Lineage | Family | Main Spoligotype | RDs | Frequency |
|---|---|---|---|---|
| lineage3 | East-African-Indian | CAS | RD750 | 0.99 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
|---|---|---|---|---|---|
| gyrA | 7582 | p.Asp94Gly | missense_variant | 0.99 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
| rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
| rpoC | 764948 | p.Leu527Val | missense_variant | 1.0 | rifampicin |
| rpsL | 781822 | p.Lys88Thr | missense_variant | 0.97 | streptomycin |
| katG | 2155168 | p.Ser315Thr | missense_variant | 0.98 | isoniazid |
| embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol |
| embB | 4248002 | p.Gln497Lys | missense_variant | 0.99 | ethambutol |
| ethA | 4327343 | c.130dupA | frameshift_variant | 0.99 | ethionamide, ethionamide |
| Gene | Chromosome position | Mutation | Type | Estimated fraction |
|---|---|---|---|---|
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
| fgd1 | 491742 | c.960T>C | synonymous_variant | 0.98 |
| rpoB | 759746 | c.-61C>T | upstream_gene_variant | 0.99 |
| rpoC | 762434 | c.-936T>G | upstream_gene_variant | 0.98 |
| rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
| katG | 2154724 | p.Arg463Leu | missense_variant | 0.99 |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.99 |
| PPE35 | 2168565 | p.Pro683Leu | missense_variant | 0.99 |
| PPE35 | 2170599 | p.Val5Ala | missense_variant | 0.97 |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
| pncA | 2289047 | c.195C>T | synonymous_variant | 0.99 |
| pncA | 2289365 | c.-125delC | upstream_gene_variant | 0.99 |
| ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 0.98 |
| ribD | 2986827 | c.-12G>A | upstream_gene_variant | 0.99 |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
| rpoA | 3878648 | c.-141C>T | upstream_gene_variant | 0.97 |
| embC | 4242075 | p.Arg738Gln | missense_variant | 0.96 |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
| ethR | 4327812 | c.265dupA | frameshift_variant | 0.97 |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 |
| gid | 4407761 | c.441delA | frameshift_variant | 0.99 |
