TB-Profiler result

Run: ERR4811379
Summary

Run ID: ERR4811379

Sample name:

Date: 20-10-2023 15:20:17

Number of reads: 7761455

Percentage reads mapped: 99.06

Strain: lineage4.4.2;lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.83
lineage4 Euro-American LAM;T;S;X;H None 0.19
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.85
lineage4.4 Euro-American S;T None 0.16
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.83
lineage4.4.2 Euro-American T1;T2 None 0.17
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.99
gyrA 8146 p.Asn282Thr missense_variant 0.15
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.85
ccsA 620625 p.Ile245Met missense_variant 0.85
rpoC 763031 c.-339T>C upstream_gene_variant 0.85
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.81
mmpS5 779615 c.-710C>G upstream_gene_variant 0.87
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.79
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.14
rpsA 1834177 c.636A>C synonymous_variant 0.82
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.88
PPE35 2167926 p.Leu896Ser missense_variant 0.79
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3066099 p.Met31Ile missense_variant 0.17
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448727 p.Leu75Arg missense_variant 0.18
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.81
clpC1 4039058 p.Phe549Leu missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.85
embA 4243991 c.759T>G synonymous_variant 0.19
embB 4246508 c.-6G>A upstream_gene_variant 0.25
aftB 4267647 p.Asp397Gly missense_variant 0.82
aftB 4268928 c.-92C>T upstream_gene_variant 0.14
aftB 4269375 c.-539G>A upstream_gene_variant 0.15
ethA 4326676 p.Ser266Arg missense_variant 0.84
ethR 4327975 p.Gln143Lys missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.82
gid 4407927 p.Glu92Asp missense_variant 0.82