TB-Profiler result

Run: ERR4814402
Summary

Run ID: ERR4814402

Sample name:

Date: 2025-05-11T03:14:57.775862

Number of reads: 3780311

Percentage reads mapped: 99.59

Median coverage: 87.0

Strain: lineage3;lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.45
lineage4 Euro-American None 0.53
lineage4.8 Euro-American (mainly T) RD219 0.57
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.46 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.5 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9596 c.2295G>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9777 p.Asn826Asp missense_variant 0.47 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
Rv0010c 13277 c.282T>C synonymous_variant 0.44 isoniazid Not assoc w R
Rv0010c 13705 c.-147G>A upstream_gene_variant 0.52 isoniazid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 0.39 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 0.52 ethionamide Not assoc w R - Interim
Rv0565c 657267 c.204G>A synonymous_variant 0.35 ethionamide Not assoc w R - Interim
nusG 734354 p.Pro34Leu missense_variant 0.44 rifampicin Not assoc w R
rpoB 759746 c.-61C>T upstream_gene_variant 0.38 rifampicin Not assoc w R
rpoB 760975 p.Met390Thr missense_variant 0.48 rifampicin Uncertain significance
rpoB 762434 c.2628T>G synonymous_variant 0.5 rifampicin Not assoc w R
rpoB 762636 p.Lys944Glu missense_variant 0.41 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764181 p.Asp271Gly missense_variant 0.52 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.4 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.42 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254598 c.-65dupA upstream_gene_variant 0.53 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1475090 n.1433A>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 0.4 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.41 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.33 pyrazinamide Not assoc w R
PPE35 2168149 p.Pro822Ser missense_variant 0.55 pyrazinamide Not assoc w R
PPE35 2170769 c.-157C>T upstream_gene_variant 0.46 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 0.46 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.52 pyrazinamide Uncertain significance
eis 2714784 c.549C>T synonymous_variant 0.45 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
eis 2714915 c.418C>T synonymous_variant 0.44 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
eis 2715432 c.-100C>T upstream_gene_variant 0.44 amikacin Uncertain significance
kanamycin Uncertain significance
ahpC 2726105 c.-88G>A upstream_gene_variant 0.44 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 0.51 amikacin Not assoc w R
ethambutol Not assoc w R
kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
Rv2680 2995848 c.-257G>A upstream_gene_variant 0.55 capreomycin Uncertain significance
ald 3086767 c.-53A>C upstream_gene_variant 0.5 cycloserine Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 0.49 cycloserine Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.56 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877752 c.756C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
panD 4044872 c.-591C>T upstream_gene_variant 0.44 pyrazinamide Uncertain significance
glpK 4138622 c.1134C>T synonymous_variant 0.48 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
embC 4242075 p.Arg738Gln missense_variant 0.46 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244990 c.1758G>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
aftB 4267715 c.1122G>A synonymous_variant 0.68 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.48 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 0.37 streptomycin Not assoc w R