TB-Profiler result

Run: ERR4827564
Summary

Run ID: ERR4827564

Sample name:

Date: 01-04-2023 18:09:43

Number of reads: 4425456

Percentage reads mapped: 99.59

Strain: lineage4.1.2.1;lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.48
lineage4 Euro-American LAM;T;S;X;H None 0.5
lineage4.1 Euro-American T;X;H None 0.49
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.53
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.5
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.49
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761110 p.Asp435Val missense_variant 0.48 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 0.51 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.55 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.46 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247431 p.Met306Ile missense_variant 0.52 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.41
fgd1 491742 c.960T>C synonymous_variant 0.49
mshA 575679 p.Asn111Ser missense_variant 0.46
mshA 575907 p.Ala187Val missense_variant 0.47
mshA 576108 p.Ala254Gly missense_variant 0.26
ccsA 620625 p.Ile245Met missense_variant 0.54
rpoB 760106 c.300G>A synonymous_variant 0.51
rpoB 760115 c.309C>T synonymous_variant 0.5
rpoC 763031 c.-339T>C upstream_gene_variant 0.34
rpoC 765150 p.Gly594Glu missense_variant 0.52
rpoC 766645 p.Glu1092Asp missense_variant 0.51
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.5
mmpL5 776182 p.Asp767Asn missense_variant 0.53
mmpS5 779615 c.-710C>G upstream_gene_variant 0.53
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.54
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.52
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.53
PPE35 2167926 p.Leu896Ser missense_variant 0.54
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.57
thyX 3067864 p.Asp28Tyr missense_variant 0.43
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.22
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
Rv3236c 3612813 p.Thr102Ala missense_variant 0.5
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.53
embA 4243460 c.228C>T synonymous_variant 0.51
embB 4246584 p.Arg24Pro missense_variant 0.35
aftB 4267647 p.Asp397Gly missense_variant 0.54
whiB6 4338513 c.9C>T synonymous_variant 0.49
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.55
gid 4407721 p.Ala161Asp missense_variant 0.47
gid 4407927 p.Glu92Asp missense_variant 0.52