TB-Profiler result

Run: ERR9120108
Summary

Run ID: ERR9120108

Sample name:

Date: 02-04-2023 10:19:20

Number of reads: 576517

Percentage reads mapped: 99.54

Strain: lineage3

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5140 c.-100C>T upstream_gene_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.92
gyrA 8056 p.Arg252Leu missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9381 p.Gly694Cys missense_variant 0.12
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764263 c.894G>T synonymous_variant 0.11
rpoC 764925 p.Gly519Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777202 p.Ala427Thr missense_variant 0.13
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918520 p.Pro194His missense_variant 0.12
katG 2154439 p.Ala558Arg missense_variant 1.0
katG 2154442 p.Lys557Arg missense_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155513 p.Lys200Met missense_variant 0.15
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170182 p.Trp144Leu missense_variant 0.15
Rv1979c 2222683 p.Trp161Leu missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518515 p.Pro134His missense_variant 0.11
eis 2715060 p.His91Gln missense_variant 0.17
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
Rv2752c 3064558 p.Tyr545Cys missense_variant 0.15
thyA 3074424 c.48G>T synonymous_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244859 p.Gly543Trp missense_variant 0.31
ethA 4326668 p.Gln269Pro missense_variant 0.12
ethA 4327064 p.Cys137Phe missense_variant 0.11
ethA 4328212 c.-740delC upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408341 c.-139G>A upstream_gene_variant 0.15