Run ID: SRR1165218
Sample name:
Date: 02-04-2023 23:40:57
Number of reads: 4764973
Percentage reads mapped: 98.78
Strain: lineage4.1.1.1;lineage2.2.2
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage2 | East-Asian | Beijing | RD105 | 0.77 |
lineage4.1 | Euro-American | T;X;H | None | 0.23 |
lineage2.2 | East-Asian (Beijing) | Beijing-RD207 | RD105;RD207 | 0.81 |
lineage2.2.2 | East-Asian (Beijing) | Beijing-RD105/RD207 | RD105;RD207 | 0.8 |
lineage4.1.1 | Euro-American (X-type) | X1;X2;X3 | None | 0.24 |
lineage4.1.1.1 | Euro-American (X-type) | X2 | RD183 | 0.22 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761110 | p.Asp435Val | missense_variant | 0.75 | rifampicin |
rpoB | 761139 | p.His445Asp | missense_variant | 0.27 | rifampicin |
rrs | 1472359 | n.514A>C | non_coding_transcript_exon_variant | 0.77 | streptomycin |
rrs | 1473246 | n.1401A>G | non_coding_transcript_exon_variant | 0.76 | kanamycin, capreomycin, aminoglycosides, amikacin |
fabG1 | 1673423 | c.-17G>T | upstream_gene_variant | 0.68 | isoniazid, ethionamide |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2288724 | c.517dupG | frameshift_variant | 0.84 | pyrazinamide, pyrazinamide |
pncA | 2288953 | p.Gly97Cys | missense_variant | 0.22 | pyrazinamide |
embB | 4247431 | p.Met306Ile | missense_variant | 0.66 | ethambutol |
embB | 4247730 | p.Gly406Asp | missense_variant | 0.38 | ethambutol |
ethA | 4326333 | p.Ala381Pro | missense_variant | 0.74 | ethionamide |
gid | 4407851 | c.351delG | frameshift_variant | 0.18 | streptomycin |
gid | 4407967 | p.Leu79Ser | missense_variant | 0.78 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.99 |
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.78 |
rpoC | 763031 | c.-339T>C | upstream_gene_variant | 0.72 |
rpoC | 765150 | p.Gly594Glu | missense_variant | 0.23 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.73 |
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 0.76 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 0.99 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.76 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2154724 | p.Arg463Leu | missense_variant | 0.64 |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.67 |
Rv1979c | 2221939 | p.Arg409Gln | missense_variant | 0.76 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
ahpC | 2726210 | c.18T>C | synonymous_variant | 0.23 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.77 |
fbiA | 3641447 | p.Thr302Met | missense_variant | 0.18 |
fbiB | 3641955 | p.Gly141Arg | missense_variant | 0.15 |
rpoA | 3877553 | p.Glu319Lys | missense_variant | 0.24 |
clpC1 | 4038219 | c.2482_2485dupGCCG | frameshift_variant | 0.13 |
embC | 4240897 | c.1035C>G | synonymous_variant | 0.44 |
embC | 4242425 | p.Arg855Gly | missense_variant | 0.18 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embC | 4242803 | p.Val981Leu | missense_variant | 0.45 |
embA | 4243460 | c.228C>T | synonymous_variant | 0.66 |
embB | 4249408 | c.2895G>A | synonymous_variant | 0.42 |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.69 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407588 | c.615A>G | synonymous_variant | 0.78 |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.75 |