TB-Profiler result

Run: SRR20969615
Summary

Run ID: SRR20969615

Sample name:

Date: 13-03-2023 12:48:03

Number of reads: 9864089

Percentage reads mapped: 99.62

Strain: lineage4.4.2;lineage2.2.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.84
lineage4 Euro-American LAM;T;S;X;H None 0.15
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.83
lineage4.4 Euro-American S;T None 0.17
lineage4.4.2 Euro-American T1;T2 None 0.16
lineage2.2.1.1 East-Asian (Beijing) Beijing-RD150 RD105;RD207;RD181;RD150 0.85
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7581 p.Ser95Thr missense_variant 1.0
gyrA 8351 p.Asp350Glu missense_variant 0.14
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.83
mshA 575907 p.Ala187Val missense_variant 0.82
ccsA 620625 p.Ile245Met missense_variant 0.86
rpoC 763031 c.-339T>C upstream_gene_variant 0.81
rpoC 763886 c.517C>A synonymous_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.84
mmpL5 776182 p.Asp767Asn missense_variant 0.81
mmpS5 779615 c.-710C>G upstream_gene_variant 0.82
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.86
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1673970 c.-232C>T upstream_gene_variant 0.17
rpsA 1834177 c.636A>C synonymous_variant 0.82
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.82
PPE35 2167926 p.Leu896Ser missense_variant 0.8
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714762 c.571C>T synonymous_variant 0.8
eis 2714846 p.Val163Ile missense_variant 0.8
Rv2752c 3066099 p.Met31Ile missense_variant 0.14
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448348 c.-156G>A upstream_gene_variant 0.23
fprA 3473996 c.-10_-9insA upstream_gene_variant 1.0
whiB7 3568629 c.46_47insCGGT frameshift_variant 0.14
Rv3236c 3612813 p.Thr102Ala missense_variant 0.87
panD 4044052 p.His77Arg missense_variant 0.88
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.86
embB 4246508 c.-6G>A upstream_gene_variant 0.21
embB 4247249 p.Gly246Arg missense_variant 0.14
embB 4248115 c.1602C>T synonymous_variant 0.84
aftB 4267647 p.Asp397Gly missense_variant 0.8
aftB 4268928 c.-92C>T upstream_gene_variant 0.14
aftB 4269375 c.-539G>A upstream_gene_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.85
gid 4407927 p.Glu92Asp missense_variant 0.86