TB-Profiler result

Run: SRR21676929
Summary

Run ID: SRR21676929

Sample name:

Date: 04-04-2023 02:45:08

Number of reads: 1235853

Percentage reads mapped: 87.47

Strain: lineage1.2.1.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 1.0
lineage1.2.1 Indo-Oceanic EAI2 RD239 1.0
lineage1.2.1.2 Indo-Oceanic NA RD239 1.0
lineage1.2.1.2.1 Indo-Oceanic NA RD239 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.65 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9260 c.1959G>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491730 c.948C>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575368 c.21T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763531 c.162G>C synonymous_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 1.0
atpE 1460907 c.-138T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.14
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.27
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.28
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.47
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.5
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.5
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.51
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.51
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.51
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.6
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.6
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.6
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.6
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.6
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.57
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.57
rrs 1472665 n.820G>A non_coding_transcript_exon_variant 0.56
rrs 1472695 n.850C>T non_coding_transcript_exon_variant 0.61
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.61
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.67
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.68
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.66
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.66
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.65
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.6
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.53
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.48
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.33
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.33
rrs 1472826 n.981G>A non_coding_transcript_exon_variant 0.33
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.37
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.33
rrs 1472836 n.991G>C non_coding_transcript_exon_variant 0.35
rrs 1472838 n.993A>T non_coding_transcript_exon_variant 0.33
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.33
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.31
rrs 1472873 n.1028C>A non_coding_transcript_exon_variant 0.28
rrs 1472875 n.1030T>A non_coding_transcript_exon_variant 0.29
rrs 1472877 n.1032T>A non_coding_transcript_exon_variant 0.29
rrs 1472880 n.1035_1036insA non_coding_transcript_exon_variant 0.29
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.29
rrs 1473206 n.1361G>A non_coding_transcript_exon_variant 0.16
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.13
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.13
rrl 1474892 n.1235G>A non_coding_transcript_exon_variant 0.19
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.19
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.19
rrl 1474903 n.1246T>A non_coding_transcript_exon_variant 0.19
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.19
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.21
rrl 1474920 n.1263G>C non_coding_transcript_exon_variant 0.22
rrl 1475126 n.1469G>T non_coding_transcript_exon_variant 0.13
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.13
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.13
rrl 1476135 n.2478T>C non_coding_transcript_exon_variant 0.3
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.35
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.42
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.44
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.35
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.35
rrl 1476195 n.2538C>A non_coding_transcript_exon_variant 0.35
rrl 1476196 n.2539C>A non_coding_transcript_exon_variant 0.35
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.35
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.35
rrl 1476204 n.2547C>A non_coding_transcript_exon_variant 0.4
rrl 1476210 n.2553G>T non_coding_transcript_exon_variant 0.4
rrl 1476211 n.2554G>T non_coding_transcript_exon_variant 0.4
rrl 1476212 n.2555T>C non_coding_transcript_exon_variant 0.4
rrl 1476213 n.2556G>A non_coding_transcript_exon_variant 0.4
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.4
rrl 1476215 n.2558C>A non_coding_transcript_exon_variant 0.4
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.69
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.68
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.73
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.69
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.69
rrl 1476275 n.2618T>A non_coding_transcript_exon_variant 0.69
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.68
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.67
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.64
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.64
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.64
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.64
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.64
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.62
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.62
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.61
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.62
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.61
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.66
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.71
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.72
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.72
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.72
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.72
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.72
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.73
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.75
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.77
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.77
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.68
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.66
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.58
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.53
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.52
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.52
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.52
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.52
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.51
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.52
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.51
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.48
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.49
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.47
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.4
rrl 1476572 n.2915G>A non_coding_transcript_exon_variant 0.36
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.36
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.25
inhA 1674162 c.-40C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2519048 p.Gly312Ser missense_variant 1.0
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0
thyA 3073958 p.Leu172Val missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339417 c.300A>G synonymous_variant 1.0
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
whiB7 3568488 c.191delG frameshift_variant 1.0
fbiB 3640557 c.-978T>C upstream_gene_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243580 c.348G>A synonymous_variant 1.0
embA 4244420 c.1188G>C synonymous_variant 1.0
embA 4245969 p.Pro913Ser missense_variant 1.0
embB 4247578 c.1065G>A synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ubiA 4269864 c.-32delG upstream_gene_variant 0.98
ethR 4328058 p.Glu170Asp missense_variant 1.0
whiB6 4338361 p.Arg54Gln missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0