Run ID: SRR25534425
Sample name:
Date: 31-01-2024 11:17:47
Number of reads: 7575700
Percentage reads mapped: 99.55
Strain: lineage4.4.2
Drug-resistance: Other
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | ||
Isoniazid | ||
Ethambutol | ||
Pyrazinamide | ||
Streptomycin | ||
Fluoroquinolones | R | gyrA p.Asp94Ala (0.96) |
Moxifloxacin | R | gyrA p.Asp94Ala (0.96) |
Ofloxacin | R | gyrA p.Asp94Ala (0.96) |
Levofloxacin | R | gyrA p.Asp94Ala (0.96) |
Ciprofloxacin | R | gyrA p.Asp94Ala (0.96) |
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.4 | Euro-American | S;T | None | 1.0 |
lineage4.4.2 | Euro-American | T1;T2 | None | 0.99 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrA | 7582 | p.Asp94Ala | missense_variant | 0.96 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpR5 | 779138 | p.Arg50Gln | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
fbiC | 1303098 | c.168C>A | synonymous_variant | 0.99 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2169041 | c.1572G>A | synonymous_variant | 0.37 |
PPE35 | 2169044 | c.1569G>C | synonymous_variant | 0.47 |
PPE35 | 2169047 | p.Ile522Val | missense_variant | 0.4 |
PPE35 | 2169053 | c.1560T>C | synonymous_variant | 0.9 |
PPE35 | 2169056 | c.1557A>G | synonymous_variant | 0.4 |
PPE35 | 2169059 | c.1554G>A | synonymous_variant | 0.51 |
PPE35 | 2169063 | p.Met517Thr | missense_variant | 0.93 |
PPE35 | 2169065 | p.Ala516Ile | missense_variant | 0.51 |
PPE35 | 2169068 | c.1545G>T | synonymous_variant | 0.59 |
PPE35 | 2169071 | c.1542A>G | synonymous_variant | 0.28 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
Rv2752c | 3066099 | p.Met31Ile | missense_variant | 0.99 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
Rv3083 | 3449878 | p.Pro459Ser | missense_variant | 1.0 |
fprA | 3473863 | c.-144G>A | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embB | 4246508 | c.-6G>A | upstream_gene_variant | 1.0 |
aftB | 4267095 | p.Pro581Gln | missense_variant | 1.0 |
aftB | 4268928 | c.-92C>T | upstream_gene_variant | 0.99 |
aftB | 4269375 | c.-539G>A | upstream_gene_variant | 0.99 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |