Run ID: SRR26558641
Sample name:
Date: 05-02-2024 22:49:42
Number of reads: 4206320
Percentage reads mapped: 98.82
Strain: lineage4.1.2
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | R | rpoB p.Asp435Tyr (0.99) |
Isoniazid | R | katG p.Ser315Thr (1.00), ahpC c.-54C>T (1.00) |
Ethambutol | R | embB p.Met306Leu (1.00) |
Pyrazinamide | R | pncA p.Thr61Pro (1.00) |
Streptomycin | ||
Fluoroquinolones | ||
Moxifloxacin | ||
Ofloxacin | ||
Levofloxacin | ||
Ciprofloxacin | ||
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.1 | Euro-American | T;X;H | None | 1.0 |
lineage4.1.2 | Euro-American | T;H | None | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761109 | p.Asp435Tyr | missense_variant | 0.99 | rifampicin |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2289061 | p.Thr61Pro | missense_variant | 1.0 | pyrazinamide |
ahpC | 2726139 | c.-54C>T | upstream_gene_variant | 1.0 | isoniazid |
embB | 4247429 | p.Met306Leu | missense_variant | 1.0 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
fgd1 | 490892 | p.Val37Gly | missense_variant | 1.0 |
rpoC | 765150 | p.Gly594Glu | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
embR | 1417140 | p.Ala70Ser | missense_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1471795 | n.-51C>G | upstream_gene_variant | 0.16 |
fabG1 | 1673249 | c.-191C>T | upstream_gene_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2169202 | p.Ser471Ala | missense_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
folC | 2747022 | p.Val193Ile | missense_variant | 1.0 |
Rv2752c | 3065377 | p.Val272Ala | missense_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
Rv3083 | 3449642 | p.Asn380Ser | missense_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
fbiA | 3641164 | p.Ile208Val | missense_variant | 1.0 |
ddn | 3986755 | c.-89G>C | upstream_gene_variant | 0.98 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embC | 4242803 | p.Val981Leu | missense_variant | 1.0 |
embA | 4245835 | p.Leu868Arg | missense_variant | 0.19 |
embB | 4247015 | p.Ser168Ala | missense_variant | 0.32 |
aftB | 4267481 | c.1356G>A | synonymous_variant | 1.0 |
ubiA | 4269317 | p.Ser173Ala | missense_variant | 1.0 |
ethA | 4327265 | p.Thr70Ser | missense_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407829 | c.373delC | frameshift_variant | 1.0 |