TB-Profiler result

Run: SRR6789629
Summary

Run ID: SRR6789629

Sample name:

Date: 2024-10-04T22:24:23.384253

Number of reads: 1310770

Percentage reads mapped: 98.0

Median coverage: 31.0

Strain: lineage1.1.2;lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.34
lineage2 East-Asian RD105 0.66
lineage1.1 Indo-Oceanic RD239 0.38
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.7
lineage2.2 East-Asian (Beijing) RD105;RD207 0.62
lineage1 Indo-Oceanic RD239 0.3
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 0.51 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.48 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8452 p.Ala384Val missense_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 0.37 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.42 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 0.75 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 0.61 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.58 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.45 ethionamide
hadA 731686 c.-244A>C upstream_gene_variant 0.43 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.29 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763884 p.Ala172Val missense_variant 0.27 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 765171 p.Pro601Leu missense_variant 0.27 rifampicin Not assoc w R
rpoC 765787 c.2418C>T synonymous_variant 0.56 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 0.71 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.77 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800357 c.-452C>A upstream_gene_variant 0.21 linezolid Not assoc w R
Rv1129c 1254204 p.Ala111Thr missense_variant 0.43 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 0.62 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
embR 1417019 p.Cys110Tyr missense_variant 0.29 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 0.34 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.52 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
inhA 1673380 c.-822C>G upstream_gene_variant 0.21 isoniazid
ethionamide
rpsA 1834177 c.636A>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 0.38 pyrazinamide Uncertain significance
PPE35 2170048 p.Leu189Val missense_variant 0.37 pyrazinamide
PPE35 2170053 p.Thr187Ser missense_variant 0.38 pyrazinamide
Rv1979c 2222308 p.Asp286Gly missense_variant 0.34 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ahpC 2726051 c.-142G>A upstream_gene_variant 0.21 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3086789 c.-31A>G upstream_gene_variant 0.25 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.77 pyrazinamide Not assoc w R - Interim
Rv3236c 3612988 c.129A>G synonymous_variant 0.3 pyrazinamide
lpqB 3624486 p.Asp142Gly missense_variant 0.39 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.95 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 0.73 rifampicin Not assoc w R
bedaquiline Uncertain significance
clpC1 4040517 p.Val63Ala missense_variant 0.25 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.34 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.29 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.24 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.75 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 0.31 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 0.46 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 0.34 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 0.64 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 0.32 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.26 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.31 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 0.52 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.4 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.6 streptomycin Not assoc w R