Run ID: a00227eb-3c26-4e6e-bf2e-da64e40cb948
Sample name:
Date: 30-04-2024 17:54:05
Number of reads: 3072042
Percentage reads mapped: 96.38
Median coverage: 0
Strain:
Spoligotype:
Drug-resistance: HR-TB
| Lineage | Family | RDs | Frequency |
|---|
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | katG | p.Ala109Val | Uncertain significance | |
| ethambutol | embB | p.Glu378Lys | Uncertain significance | |
| pyrazinamide | pncA | p.Gly108Arg | Assoc w R - interim | |
| p.Ala102Thr | Uncertain significance | |||
| moxifloxacin | ||||
| levofloxacin | ||||
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | gid | p.Trp45* | Assoc w R - interim | |
| amikacin | ||||
| kanamycin | ||||
| capreomycin | ||||
| clofazimine | ||||
| ethionamide | ethA | p.Trp109* | Assoc w R - interim | |
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| katG | 2155786 | p.Ala109Val | missense_variant | 0.13 | isoniazid | Uncertain significance | |
| pncA | 2288920 | p.Gly108Arg | missense_variant | 0.17 | pyrazinamide | Assoc w R - interim | |
| pncA | 2288938 | p.Ala102Thr | missense_variant | 0.16 | pyrazinamide | Uncertain significance | |
| embB | 4247645 | p.Glu378Lys | missense_variant | 0.1 | ethambutol | Uncertain significance | |
| ethA | 4327148 | p.Trp109* | stop_gained | 0.29 | ethionamide | Assoc w R - interim | |
| gid | 4408069 | p.Trp45* | stop_gained | 0.21 | streptomycin | Assoc w R - interim |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrA | 6358 | c.-944C>T | upstream_gene_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6413 | c.-889C>T | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6421 | c.-881C>T | upstream_gene_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrB | 6521 | p.Arg428Trp | missense_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6646 | c.-656C>T | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrB | 6711 | p.Ala491Val | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6721 | c.-581C>T | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6736 | c.-566C>T | upstream_gene_variant | 0.2 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6781 | c.-521C>T | upstream_gene_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6886 | c.-416C>T | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrB | 6887 | p.Arg550Trp | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6892 | c.-410C>T | upstream_gene_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6913 | c.-389C>T | upstream_gene_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7655 | c.354G>A | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7697 | c.396C>T | synonymous_variant | 0.14 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| rpoB | 760769 | c.963C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760846 | p.Thr347Ile | missense_variant | 0.58 | rifampicin | Uncertain significance |
| rpoB | 760879 | p.Pro358Leu | missense_variant | 0.58 | rifampicin | Uncertain significance |
| rpoB | 760929 | p.Val375Ile | missense_variant | 0.2 | rifampicin | |
| rpoB | 760932 | p.Gly376Ser | missense_variant | 0.2 | rifampicin | |
| rpoB | 761141 | c.1335C>T | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 761204 | c.1398C>T | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 761218 | p.Pro471Leu | missense_variant | 0.12 | rifampicin | |
| rpoB | 761351 | c.1545C>T | synonymous_variant | 0.2 | rifampicin | |
| mmpR5 | 779024 | p.Ala12Val | missense_variant | 0.13 | clofazimine | |
| bedaquiline | ||||||
| mmpR5 | 779246 | p.Ala86Val | missense_variant | 0.11 | clofazimine | |
| bedaquiline | ||||||
| mmpR5 | 779407 | p.Arg140Trp | missense_variant | 0.12 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779484 | c.-579G>A | upstream_gene_variant | 0.13 | clofazimine | |
| bedaquiline | ||||||
| rplC | 801093 | c.285C>T | synonymous_variant | 0.18 | linezolid | |
| rrs | 1471866 | n.21C>T | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1471946 | n.101C>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.23 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472172 | n.327T>C | non_coding_transcript_exon_variant | 0.26 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472179 | n.334C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472225 | n.380C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.22 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472294 | n.449G>A | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472340 | n.495C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472447 | n.602C>T | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472487 | n.642C>T | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472515 | n.670C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472615 | n.770C>T | non_coding_transcript_exon_variant | 0.2 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472697 | n.852T>C | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472724 | n.879G>A | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472769 | n.924C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472801 | n.956G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472858 | n.1013G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472872 | n.1027G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472976 | n.1131G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472995 | n.1150C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472998 | n.1153C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473011 | n.1166G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473032 | n.1187C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473037 | n.1192C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473063 | n.1218C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473090 | n.1245G>A | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473128 | n.1283C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473180 | n.1335G>A | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473190 | n.1345G>A | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473204 | n.1359C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473250 | n.1405C>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473305 | n.1460G>A | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473325 | n.1480G>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473326 | n.1481G>A | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473373 | n.1528C>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473377 | n.1532C>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1473385 | n.-273G>A | upstream_gene_variant | 0.17 | linezolid | |
| rrl | 1473401 | n.-257G>A | upstream_gene_variant | 0.18 | linezolid | |
| rrl | 1473404 | n.-254C>T | upstream_gene_variant | 0.2 | linezolid | |
| rrl | 1473410 | n.-248G>A | upstream_gene_variant | 0.18 | linezolid | |
| rrl | 1475978 | n.2321C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476006 | n.2349G>A | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476008 | n.2351A>G | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1476055 | n.2398C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1476246 | n.2589G>A | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1476380 | n.2723G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1476444 | n.2787G>A | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476530 | n.2873C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476587 | n.2930C>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| inhA | 1673493 | c.-709C>T | upstream_gene_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| fabG1 | 1673770 | p.Ala111Pro | missense_variant | 0.49 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673868 | c.-334C>T | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673931 | c.-271C>T | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674000 | c.-202C>T | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| fabG1 | 1674038 | p.Gln200Arg | missense_variant | 0.2 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674328 | p.Arg43Trp | missense_variant | 0.2 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674442 | p.Ala81Thr | missense_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674459 | c.258C>T | synonymous_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674465 | c.264C>T | synonymous_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674529 | p.Asp110Asn | missense_variant | 0.12 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674571 | p.Ala124Thr | missense_variant | 0.12 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674597 | c.396G>A | synonymous_variant | 0.11 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674600 | c.399G>A | synonymous_variant | 0.11 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674608 | p.Pro136Leu | missense_variant | 0.13 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674653 | p.Pro151Leu | missense_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674729 | c.528G>A | synonymous_variant | 0.12 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674772 | p.Ala191Thr | missense_variant | 0.12 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| inhA | 1674792 | c.591G>A | synonymous_variant | 0.12 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674803 | p.Ala201Val | missense_variant | 0.1 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674822 | c.621C>T | synonymous_variant | 0.11 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674829 | p.Glu210Lys | missense_variant | 0.16 | ethionamide | |
| isoniazid | ||||||
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918009 | p.Ala24Thr | missense_variant | 0.55 | capreomycin | |
| tlyA | 1918138 | p.Ala67Thr | missense_variant | 0.53 | capreomycin | |
| tlyA | 1918193 | p.Arg85His | missense_variant | 0.53 | capreomycin | |
| tlyA | 1918253 | p.Ala105Val | missense_variant | 0.34 | capreomycin | |
| tlyA | 1918255 | p.Ala106Thr | missense_variant | 0.55 | capreomycin | |
| tlyA | 1918305 | c.366G>A | synonymous_variant | 0.55 | capreomycin | |
| tlyA | 1918356 | c.417C>T | synonymous_variant | 0.34 | capreomycin | |
| tlyA | 1918387 | c.448C>T | synonymous_variant | 0.34 | capreomycin | |
| tlyA | 1918433 | p.Pro165Leu | missense_variant | 0.34 | capreomycin | |
| tlyA | 1918495 | p.Glu186Lys | missense_variant | 0.53 | capreomycin | |
| tlyA | 1918533 | c.594C>T | synonymous_variant | 0.36 | capreomycin | |
| tlyA | 1918623 | c.684C>T | synonymous_variant | 0.39 | capreomycin | |
| tlyA | 1918656 | c.717C>T | synonymous_variant | 0.38 | capreomycin | |
| katG | 2155179 | c.933C>T | synonymous_variant | 0.15 | isoniazid | |
| katG | 2155189 | p.Thr308Ile | missense_variant | 0.14 | isoniazid | |
| katG | 2155332 | c.780C>T | synonymous_variant | 0.12 | isoniazid | |
| katG | 2155364 | p.Glu250Lys | missense_variant | 0.13 | isoniazid | |
| katG | 2155378 | p.Ala245Val | missense_variant | 0.15 | isoniazid | |
| katG | 2155424 | p.Val230Met | missense_variant | 0.14 | isoniazid | |
| katG | 2155454 | c.658C>T | synonymous_variant | 0.12 | isoniazid | |
| katG | 2155487 | p.Arg209Cys | missense_variant | 0.15 | isoniazid | |
| katG | 2155506 | c.606C>T | synonymous_variant | 0.21 | isoniazid | |
| katG | 2155511 | p.Glu201Lys | missense_variant | 0.14 | isoniazid | |
| katG | 2155516 | p.Gly199Asp | missense_variant | 0.14 | isoniazid | |
| katG | 2155535 | p.Pro193Ser | missense_variant | 0.12 | isoniazid | |
| katG | 2155602 | c.510C>T | synonymous_variant | 0.12 | isoniazid | |
| katG | 2155609 | p.Ala168Val | missense_variant | 0.19 | isoniazid | |
| katG | 2155640 | p.Lys158Glu | missense_variant | 0.1 | isoniazid | Uncertain significance |
| katG | 2155725 | c.387C>T | synonymous_variant | 0.14 | isoniazid | |
| katG | 2155755 | c.357C>T | synonymous_variant | 0.14 | isoniazid | |
| katG | 2155764 | c.348C>T | synonymous_variant | 0.14 | isoniazid | |
| katG | 2155814 | p.Pro100Ser | missense_variant | 0.11 | isoniazid | |
| katG | 2155857 | c.255C>T | synonymous_variant | 0.13 | isoniazid | |
| pncA | 2288915 | c.327C>T | synonymous_variant | 0.17 | pyrazinamide | |
| pncA | 2288989 | c.253C>T | synonymous_variant | 0.16 | pyrazinamide | |
| pncA | 2289011 | c.231C>T | synonymous_variant | 0.16 | pyrazinamide | |
| pncA | 2289045 | p.Ser66Leu | missense_variant | 0.16 | pyrazinamide | Uncertain significance |
| pncA | 2289047 | c.195C>T | synonymous_variant | 0.13 | pyrazinamide | |
| pncA | 2289113 | c.129C>T | synonymous_variant | 0.16 | pyrazinamide | |
| pncA | 2289197 | c.45G>A | synonymous_variant | 0.3 | pyrazinamide | |
| pncA | 2289292 | c.-51C>T | upstream_gene_variant | 0.16 | pyrazinamide | |
| ahpC | 2726038 | c.-155G>A | upstream_gene_variant | 0.25 | isoniazid | |
| ahpC | 2726044 | c.-149G>A | upstream_gene_variant | 0.32 | isoniazid | |
| ahpC | 2726101 | c.-92G>A | upstream_gene_variant | 0.13 | isoniazid | |
| ahpC | 2726214 | p.Asp8Asn | missense_variant | 0.21 | isoniazid | |
| ahpC | 2726369 | c.177C>T | synonymous_variant | 0.12 | isoniazid | |
| ahpC | 2726479 | p.Trp96* | stop_gained | 0.22 | isoniazid | |
| ahpC | 2726512 | p.Pro107Leu | missense_variant | 0.12 | isoniazid | |
| ahpC | 2726572 | p.Ala127Val | missense_variant | 0.1 | isoniazid | |
| embB | 4247398 | c.885G>A | synonymous_variant | 0.12 | ethambutol | |
| embB | 4247490 | p.Pro326Leu | missense_variant | 0.11 | ethambutol | |
| embB | 4247508 | p.Trp332* | stop_gained | 0.11 | ethambutol | |
| embB | 4247602 | c.1089G>A | synonymous_variant | 0.11 | ethambutol | |
| embB | 4247618 | p.Val369Met | missense_variant | 0.1 | ethambutol | Uncertain significance |
| embB | 4247670 | p.Ala386Val | missense_variant | 0.11 | ethambutol | |
| embB | 4247774 | p.Arg421Trp | missense_variant | 0.11 | ethambutol | |
| embB | 4247792 | p.Arg427Trp | missense_variant | 0.11 | ethambutol | |
| embB | 4247803 | c.1290G>A | synonymous_variant | 0.11 | ethambutol | |
| embB | 4247823 | p.Thr437Ile | missense_variant | 0.11 | ethambutol | |
| embB | 4247840 | p.Gly443Ser | missense_variant | 0.11 | ethambutol | Uncertain significance |
| embB | 4247917 | c.1404C>T | synonymous_variant | 0.17 | ethambutol | |
| embB | 4247990 | p.Val493Met | missense_variant | 0.11 | ethambutol | Uncertain significance |
| ethA | 4326077 | p.Arg466Gln | missense_variant | 0.14 | ethionamide | |
| ethA | 4326091 | c.1383C>T | synonymous_variant | 0.1 | ethionamide | |
| ethA | 4326175 | c.1299G>A | synonymous_variant | 0.12 | ethionamide | |
| ethA | 4326332 | p.Ala381Val | missense_variant | 0.17 | ethionamide | |
| ethA | 4326401 | p.Gly358Glu | missense_variant | 0.13 | ethionamide | |
| ethA | 4326522 | p.Glu318Lys | missense_variant | 0.13 | ethionamide | |
| ethA | 4326546 | p.Val310Ile | missense_variant | 0.13 | ethionamide | Uncertain significance |
| ethA | 4326579 | p.Gly299Ser | missense_variant | 0.13 | ethionamide | |
| ethA | 4326593 | p.Cys294Tyr | missense_variant | 0.12 | ethionamide | Uncertain significance |
| ethR | 4326733 | c.-816C>T | upstream_gene_variant | 0.12 | ethionamide | |
| ethA | 4326764 | p.Ala237Met | missense_variant | 0.12 | ethionamide | |
| ethA | 4326810 | p.Ala222Thr | missense_variant | 0.26 | ethionamide | Uncertain significance |
| ethA | 4326819 | p.Asp219Asn | missense_variant | 0.26 | ethionamide | |
| ethR | 4326835 | c.-714C>T | upstream_gene_variant | 0.3 | ethionamide | |
| ethA | 4326998 | p.Gly159Glu | missense_variant | 0.27 | ethionamide | |
| ethR | 4327012 | c.-537C>T | upstream_gene_variant | 0.3 | ethionamide | |
| ethA | 4327044 | p.Asp144Asn | missense_variant | 0.31 | ethionamide | Uncertain significance |
| ethA | 4327047 | p.Tyr143His | missense_variant | 0.31 | ethionamide | |
| ethA | 4327059 | p.Gly139Ser | missense_variant | 0.41 | ethionamide | Uncertain significance |
| ethA | 4327104 | p.Gly124Ser | missense_variant | 0.41 | ethionamide | |
| ethR | 4327162 | c.-387C>T | upstream_gene_variant | 0.72 | ethionamide | |
| ethA | 4327197 | p.Gly93Arg | missense_variant | 0.28 | ethionamide | Uncertain significance |
| ethA | 4327209 | p.Ala89Thr | missense_variant | 0.42 | ethionamide | |
| ethA | 4327259 | p.Arg72Gln | missense_variant | 0.33 | ethionamide | |
| ethR | 4327333 | c.-216C>T | upstream_gene_variant | 0.26 | ethionamide | |
| ethR | 4327360 | c.-189C>T | upstream_gene_variant | 0.32 | ethionamide | |
| ethA | 4327368 | p.Glu36Lys | missense_variant | 0.25 | ethionamide | Uncertain significance |
| ethA | 4327427 | p.Gly16Asp | missense_variant | 0.32 | ethionamide | Uncertain significance |
| gid | 4407591 | c.612C>T | synonymous_variant | 0.2 | streptomycin | |
| gid | 4407612 | c.591T>C | synonymous_variant | 0.13 | streptomycin | |
| gid | 4407615 | c.588G>A | synonymous_variant | 0.23 | streptomycin | |
| gid | 4407659 | p.Gly182Ser | missense_variant | 0.22 | streptomycin | |
| gid | 4407747 | c.456G>A | synonymous_variant | 0.1 | streptomycin | |
| gid | 4407785 | p.Ala140Thr | missense_variant | 0.22 | streptomycin | |
| gid | 4407855 | c.348G>A | synonymous_variant | 0.1 | streptomycin | |
| gid | 4407935 | p.Leu90Phe | missense_variant | 0.2 | streptomycin | Uncertain significance |
| gid | 4407942 | c.261G>A | synonymous_variant | 0.21 | streptomycin | |
| gid | 4407986 | p.Gly73Arg | missense_variant | 0.1 | streptomycin | Uncertain significance |
| gid | 4408041 | c.162G>A | synonymous_variant | 0.1 | streptomycin | |
| gid | 4408081 | p.Val41Ala | missense_variant | 0.12 | streptomycin | Uncertain significance |
| gid | 4408110 | c.93G>A | synonymous_variant | 0.13 | streptomycin | |
| gid | 4408124 | p.Ala27Thr | missense_variant | 0.21 | streptomycin |
