Run ID: DRR130059
Sample name:
Date: 31-03-2023 07:03:15
Number of reads: 1537702
Percentage reads mapped: 99.53
Strain: lineage4.5
Drug-resistance: Pre-XDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.5 | Euro-American | H;T | RD122 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrA | 7582 | p.Asp94Gly | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rpoB | 761111 | p.Asp435Glu | missense_variant | 1.0 | rifampicin |
rpoB | 761128 | p.Ser441Leu | missense_variant | 1.0 | rifampicin |
rpsL | 781687 | p.Lys43Arg | missense_variant | 1.0 | streptomycin |
pncA | 2288933 | p.Tyr103* | stop_gained | 1.0 | pyrazinamide |
ahpC | 2726139 | c.-54C>T | upstream_gene_variant | 1.0 | isoniazid |
katG | 2152059 | c.-1564_*1829del | transcript_ablation | 1.0 | isoniazid |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 7892 | c.591G>A | synonymous_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.99 |
ccsA | 620029 | c.139C>T | synonymous_variant | 1.0 |
rpoB | 761776 | p.Asp657Ala | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpR5 | 779127 | c.139dupG | frameshift_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
fbiC | 1305494 | c.2565_*55delGGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCAATCT | frameshift_variant&stop_lost&splice_region_variant | 0.38 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrl | 1475352 | n.1695T>C | non_coding_transcript_exon_variant | 1.0 |
rrl | 1475926 | n.2269_2270insT | non_coding_transcript_exon_variant | 1.0 |
rpsA | 1833573 | p.Val11Gly | missense_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2170568 | p.Ile15Met | missense_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
ribD | 2987120 | c.282C>T | synonymous_variant | 1.0 |
Rv2752c | 3065949 | p.His81Gln | missense_variant | 1.0 |
ald | 3086906 | c.89dupG | frameshift_variant | 1.0 |
Rv3083 | 3449711 | p.Gly403Asp | missense_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
whiB7 | 3568603 | p.Asp26Gly | missense_variant | 1.0 |
alr | 3841146 | p.Ala92Asp | missense_variant | 1.0 |
rpoA | 3878575 | c.-68C>T | upstream_gene_variant | 1.0 |
clpC1 | 4038318 | p.Pro796Leu | missense_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
ethA | 4326450 | p.Thr342Ala | missense_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
fbiC | 1305494 | c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | frameshift_variant&stop_lost&splice_region_variant | 1.0 |