TB-Profiler result

Run: ERR11081950
Summary

Run ID: ERR11081950

Sample name:

Date: 2024-10-05T07:57:57.979345

Number of reads: 5377208

Percentage reads mapped: 99.61

Median coverage: 145.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.His445Cys Assoc w R
isoniazid katG c.151_152insCAA Mutation from literature
ahpC c.-52C>T Uncertain significance Mutation from literature
ethambutol embB p.Met306Leu Assoc w R
pyrazinamide pncA p.Lys96Glu Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761139 p.His445Cys missense_variant 1.0 rifampicin Assoc w R
katG 2155960 c.151_152insCAA conservative_inframe_insertion 1.0 isoniazid Mutation from literature
pncA 2288956 p.Lys96Glu missense_variant 1.0 pyrazinamide Assoc w R
ahpC 2726141 c.-52C>T upstream_gene_variant 1.0 isoniazid Uncertain significance Mutation from literature
embB 4247429 p.Met306Leu missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7879 p.Asn193Ser missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
mmaA3 737720 p.Ala144Thr missense_variant 0.99 isoniazid
rpoB 760278 p.Gly158Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254144 p.Thr131Pro missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155413 p.Glu233Asp missense_variant 0.26 isoniazid
katG 2155808 p.Phe102Val missense_variant 0.64 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
whiB7 3568623 c.57G>A synonymous_variant 1.0 kanamycin
amikacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
alr 3840631 p.Pro264Ser missense_variant 1.0 cycloserine
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243226 c.-7G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
gid 4407758 p.Ser149Arg missense_variant 0.99 streptomycin Uncertain significance