TB-Profiler result

Run: ERR190379
Summary

Run ID: ERR190379

Sample name:

Date: 20-10-2023 22:43:47

Number of reads: 4147083

Percentage reads mapped: 99.14

Strain: lineage4.3.4.2.1;lineage1.1.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.23
lineage1 Indo-Oceanic EAI RD239 0.76
lineage4.3 Euro-American (LAM) mainly-LAM None 0.22
lineage1.1 Indo-Oceanic EAI3;EAI4;EAI5;EAI6 RD239 0.77
lineage1.1.2 Indo-Oceanic EAI3;EAI5 RD239 0.75
lineage4.3.4 Euro-American (LAM) LAM RD174 0.24
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 0.22
lineage4.3.4.2.1 Euro-American (LAM) LAM11 RD174 0.2
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 0.79
gyrB 6124 c.885C>T synonymous_variant 0.79
gyrB 6140 p.Val301Leu missense_variant 0.21
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 0.74
gyrA 9143 c.1842T>C synonymous_variant 0.65
gyrA 9304 p.Gly668Asp missense_variant 0.98
fgd1 491742 c.960T>C synonymous_variant 0.8
rpoC 763031 c.-339T>C upstream_gene_variant 0.72
rpoC 763884 p.Ala172Val missense_variant 0.81
rpoC 763886 c.517C>A synonymous_variant 0.8
rpoC 764995 c.1626C>G synonymous_variant 0.2
rpoC 765171 p.Pro601Leu missense_variant 0.74
rpoC 765787 c.2418C>T synonymous_variant 0.72
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.69
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 0.78
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103232 c.-190G>T upstream_gene_variant 0.8
katG 2154724 p.Arg463Leu missense_variant 0.84
PPE35 2167926 p.Leu896Ser missense_variant 0.78
PPE35 2167983 p.Gly877Asp missense_variant 0.77
PPE35 2168166 p.Thr816Met missense_variant 0.81
Rv1979c 2222308 p.Asp286Gly missense_variant 0.83
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 0.78
eis 2715131 p.Arg68Trp missense_variant 0.77
ahpC 2726051 c.-142G>A upstream_gene_variant 0.8
Rv2752c 3064632 c.1560C>T synonymous_variant 0.82
thyA 3073868 p.Thr202Ala missense_variant 0.27
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086789 c.-31A>G upstream_gene_variant 0.86
Rv3083 3448714 p.Asp71His missense_variant 0.8
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
fprA 3474597 c.591C>A synonymous_variant 0.87
fprA 3475159 p.Asn385Asp missense_variant 0.83
Rv3236c 3612009 p.Ala370Thr missense_variant 0.23
alr 3840719 c.702A>G synonymous_variant 0.2
clpC1 4038287 c.2418C>T synonymous_variant 0.26
clpC1 4040517 p.Val63Ala missense_variant 0.81
embC 4240671 p.Thr270Ile missense_variant 0.7
embC 4241042 p.Asn394Asp missense_variant 0.73
embC 4241539 c.1677T>C synonymous_variant 0.24
embA 4242643 c.-590C>T upstream_gene_variant 0.98
embA 4243848 p.Val206Met missense_variant 0.82
embA 4245969 p.Pro913Ser missense_variant 0.75
embB 4247646 p.Glu378Ala missense_variant 0.72
aftB 4268671 p.Glu56Gln missense_variant 0.86
ubiA 4269387 p.Glu149Asp missense_variant 0.78
aftB 4269606 c.-770T>C upstream_gene_variant 0.72
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 0.81
gid 4407588 c.615A>G synonymous_variant 0.78
gid 4407873 c.330G>T synonymous_variant 0.77
gid 4408156 p.Leu16Arg missense_variant 0.23
gid 4408213 c.-11C>T upstream_gene_variant 0.75