Run ID: ERR2516375
Sample name:
Date: 15-08-2022 12:14:29
Number of reads: 7258441
Percentage reads mapped: 77.28
Strain: lineage4.3.3
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.3 | Euro-American (LAM) | mainly-LAM | None | 1.0 |
lineage4.3.3 | Euro-American (LAM) | LAM;T | RD115 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
rrs | 1472359 | n.514A>C | non_coding_transcript_exon_variant | 1.0 | streptomycin |
fabG1 | 1673425 | c.-15C>T | upstream_gene_variant | 1.0 | isoniazid, ethionamide |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
embB | 4247469 | p.Tyr319Ser | missense_variant | 1.0 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 8040 | p.Gly247Ser | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
rpoC | 764667 | p.Gly433Ala | missense_variant | 1.0 |
rpoC | 764995 | c.1626C>G | synonymous_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
fbiC | 1303095 | c.165G>A | synonymous_variant | 1.0 |
fbiC | 1304962 | p.Trp678Gly | missense_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1472557 | n.712G>A | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472570 | n.725G>A | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472571 | n.726G>C | non_coding_transcript_exon_variant | 0.29 |
rrs | 1472575 | n.730C>T | non_coding_transcript_exon_variant | 0.27 |
rrs | 1472579 | n.734G>T | non_coding_transcript_exon_variant | 0.28 |
rrs | 1472581 | n.736A>T | non_coding_transcript_exon_variant | 0.28 |
rrs | 1472598 | n.753A>C | non_coding_transcript_exon_variant | 0.31 |
rrs | 1472616 | n.771G>A | non_coding_transcript_exon_variant | 0.22 |
rrs | 1472697 | n.852T>C | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472701 | n.856T>A | non_coding_transcript_exon_variant | 0.24 |
rrs | 1472713 | n.868T>C | non_coding_transcript_exon_variant | 0.45 |
rrs | 1472716 | n.871C>T | non_coding_transcript_exon_variant | 0.49 |
rrs | 1472744 | n.899A>G | non_coding_transcript_exon_variant | 0.68 |
rrs | 1472781 | n.936C>T | non_coding_transcript_exon_variant | 0.71 |
rrs | 1472793 | n.948A>T | non_coding_transcript_exon_variant | 0.68 |
rrs | 1472803 | n.958T>A | non_coding_transcript_exon_variant | 0.65 |
rrs | 1472824 | n.979T>A | non_coding_transcript_exon_variant | 0.26 |
rrs | 1472827 | n.982G>T | non_coding_transcript_exon_variant | 0.11 |
rrs | 1472828 | n.983T>C | non_coding_transcript_exon_variant | 0.11 |
rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.2 |
rrs | 1473053 | n.1208T>A | non_coding_transcript_exon_variant | 0.2 |
rrs | 1473056 | n.1211A>T | non_coding_transcript_exon_variant | 0.21 |
rrs | 1473062 | n.1217T>A | non_coding_transcript_exon_variant | 0.21 |
rrs | 1473068 | n.1223A>G | non_coding_transcript_exon_variant | 0.22 |
rrs | 1473080 | n.1235C>A | non_coding_transcript_exon_variant | 0.24 |
rrs | 1473081 | n.1236C>T | non_coding_transcript_exon_variant | 0.24 |
rrs | 1473099 | n.1254T>G | non_coding_transcript_exon_variant | 0.23 |
rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.23 |
rpsA | 1834836 | p.Met432Thr | missense_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2156196 | c.-85C>T | upstream_gene_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
kasA | 2518919 | p.Gly269Ser | missense_variant | 0.99 |
folC | 2746340 | p.Ala420Val | missense_variant | 1.0 |
ribD | 2986827 | c.-12G>A | upstream_gene_variant | 1.0 |
thyA | 3073806 | c.666C>G | synonymous_variant | 0.12 |
thyA | 3073868 | p.Thr202Ala | missense_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 |
clpC1 | 4038968 | c.1737G>A | synonymous_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 |