Run ID: ERR3014621
Sample name:
Date: 20-10-2023 21:31:20
Number of reads: 1853509
Percentage reads mapped: 95.36
Strain: lineage4.1.2.1
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | R | rpoB p.Ser450Leu (1.00) |
Isoniazid | R | katG p.Ser315Thr (1.00) |
Ethambutol | R | embB p.Met306Ile (1.00) |
Pyrazinamide | R | pncA c.-11A>C (1.00) |
Streptomycin | ||
Fluoroquinolones | ||
Moxifloxacin | ||
Ofloxacin | ||
Levofloxacin | ||
Ciprofloxacin | ||
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.1 | Euro-American | T;X;H | None | 1.0 |
lineage4.1.2 | Euro-American | T;H | None | 1.0 |
lineage4.1.2.1 | Euro-American (Haarlem) | T1;H1 | RD182 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2289252 | c.-11A>C | upstream_gene_variant | 1.0 | pyrazinamide |
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
fgd1 | 491591 | p.Lys270Met | missense_variant | 1.0 |
mshA | 575679 | p.Asn111Ser | missense_variant | 1.0 |
rpoB | 760115 | c.309C>T | synonymous_variant | 1.0 |
rpoB | 761406 | p.Val534Met | missense_variant | 1.0 |
rpoC | 765150 | p.Gly594Glu | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1473053 | n.1208T>A | non_coding_transcript_exon_variant | 0.14 |
rrl | 1476332 | n.2675G>C | non_coding_transcript_exon_variant | 0.13 |
rrl | 1476338 | n.2681C>T | non_coding_transcript_exon_variant | 0.14 |
rrl | 1476353 | n.2696G>T | non_coding_transcript_exon_variant | 0.2 |
rrl | 1476358 | n.2701T>C | non_coding_transcript_exon_variant | 0.22 |
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.22 |
rrl | 1476372 | n.2715T>C | non_coding_transcript_exon_variant | 0.22 |
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.22 |
rrl | 1476383 | n.2726T>A | non_coding_transcript_exon_variant | 0.22 |
rrl | 1476408 | n.2751G>A | non_coding_transcript_exon_variant | 0.24 |
rrl | 1476425 | n.2768G>A | non_coding_transcript_exon_variant | 0.23 |
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.23 |
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.23 |
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.24 |
rrl | 1476481 | n.2824T>C | non_coding_transcript_exon_variant | 0.19 |
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.13 |
rrl | 1476514 | n.2857C>T | non_coding_transcript_exon_variant | 0.12 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
kasA | 2518076 | c.-39C>T | upstream_gene_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
embC | 4239853 | c.-10A>C | upstream_gene_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embC | 4242803 | p.Val981Leu | missense_variant | 1.0 |
embB | 4247028 | p.Leu172Arg | missense_variant | 0.21 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4408064 | p.Arg47Trp | missense_variant | 1.0 |