TB-Profiler result

Run: ERR4553622
Summary

Run ID: ERR4553622

Sample name:

Date: 01-04-2023 06:15:21

Number of reads: 1179572

Percentage reads mapped: 99.6

Strain:

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1.1.3 Indo-Oceanic EAI6 RD239 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
inhA 1674481 p.Ser94Ala missense_variant 0.9 isoniazid, ethionamide
embA 4243221 c.-12C>T upstream_gene_variant 0.95 ethambutol
embB 4247729 p.Gly406Ser missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 0.8
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9362 c.2061C>T synonymous_variant 0.97
fgd1 491448 c.666C>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.32
mshA 576675 p.Arg443His missense_variant 1.0
rpoB 762967 p.Lys1054Arg missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 765171 p.Pro601Leu missense_variant 0.75
rpoC 765230 p.Ala621Thr missense_variant 0.94
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 778099 p.Asp128Asn missense_variant 1.0
mmpS5 778581 p.Gly109Ser missense_variant 0.97
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 0.93
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289070 p.Phe58Val missense_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
thyX 3068043 c.-98A>G upstream_gene_variant 1.0
ald 3086767 c.-53A>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.17
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 0.67
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243848 p.Val206Met missense_variant 1.0
embA 4245314 c.2082G>C synonymous_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.27
embB 4247646 p.Glu378Ala missense_variant 0.75
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethA 4326854 p.Arg207His missense_variant 1.0
whiB6 4338308 c.213dupT frameshift_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407780 c.423G>A synonymous_variant 0.92
gid 4407790 p.Ala138Val missense_variant 0.92