TB-Profiler result

Run: ERR4799663
Summary

Run ID: ERR4799663

Sample name:

Date: 20-10-2023 03:58:33

Number of reads: 4882641

Percentage reads mapped: 99.55

Strain: lineage3;lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin R rpoB p.Ser450Leu (0.90)
Isoniazid R katG p.Ser315Thr (0.84)
Ethambutol R embB p.Met306Val (0.84)
Pyrazinamide R pncA p.Leu27Pro (0.87)
Streptomycin R rpsL p.Lys43Arg (0.90)
Fluoroquinolones R gyrA p.Asp94Gly (0.84)
Moxifloxacin R gyrA p.Asp94Gly (0.84)
Ofloxacin R gyrA p.Asp94Gly (0.84)
Levofloxacin R gyrA p.Asp94Gly (0.84)
Ciprofloxacin R gyrA p.Asp94Gly (0.84)
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide R ethA c.776_777dupGC (0.86)
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 0.14
lineage2 East-Asian Beijing RD105 0.85
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.84
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.85
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Gly missense_variant 0.84 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 0.9 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.9 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.84 isoniazid
pncA 2289162 p.Leu27Pro missense_variant 0.87 pyrazinamide
embB 4247429 p.Met306Val missense_variant 0.84 ethambutol
ethA 4326696 c.776_777dupGC frameshift_variant 0.86 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 0.99
fgd1 491742 c.960T>C synonymous_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 0.85
rpoB 759746 c.-61C>T upstream_gene_variant 0.13
rpoC 762434 c.-936T>G upstream_gene_variant 0.17
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766488 p.Pro1040Arg missense_variant 0.78
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 0.85
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.85
rrs 1471659 n.-187C>T upstream_gene_variant 0.99
rrs 1472608 n.763T>C non_coding_transcript_exon_variant 0.86
rpsA 1834177 c.636A>C synonymous_variant 0.84
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168565 p.Pro683Leu missense_variant 0.19
PPE35 2170599 p.Val5Ala missense_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 0.11
ahpC 2726105 c.-88G>A upstream_gene_variant 0.17
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086888 c.69C>A synonymous_variant 0.16
Rv3083 3449006 p.His168Pro missense_variant 0.82
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.81
rpoA 3878648 c.-141C>T upstream_gene_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.8
aftB 4267647 p.Asp397Gly missense_variant 0.78
ethA 4326676 p.Ser266Arg missense_variant 0.89
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 0.81